2020
DOI: 10.3390/medicina56020080
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CPAP Effect on Cardiopulmonary Exercise Testing Performance in Patients with Moderate-Severe OSA and Cardiometabolic Comorbidities

Abstract: Background and Objectives: Obstructive sleep apnea (OSA) is associated with daytime somnolence, cognitive impairment and high cardiovascular morbidity and mortality. Obesity, associated cardiovascular comorbidities, accelerated erythropoiesis and muscular mitochondrial energetic dysfunctions negatively influence exercise tolerance in moderate-severe OSA patients. The cardiopulmonary exercise testing (CPET) offers an integrated assessment of the individual's aerobic capacity and helps distinguish the main cause… Show more

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Cited by 9 publications
(4 citation statements)
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“…All patients were educated regarding the importance of a healthy lifestyle (nutrition and physical activity) and the need of daily PAP use and received free PAP therapy for 2 months (DreamStation Auto CPAP–Philips Respironics, REMstar Auto C-Flex CPAP–Philips Respironics or AirSense 10 AutoSet CPAP–ResMed). Data regarding our cohort, study protocol and preliminary (2 month) results have been previously published [ 33 , 34 , 35 , 36 , 37 ].…”
Section: Methodsmentioning
confidence: 99%
“…All patients were educated regarding the importance of a healthy lifestyle (nutrition and physical activity) and the need of daily PAP use and received free PAP therapy for 2 months (DreamStation Auto CPAP–Philips Respironics, REMstar Auto C-Flex CPAP–Philips Respironics or AirSense 10 AutoSet CPAP–ResMed). Data regarding our cohort, study protocol and preliminary (2 month) results have been previously published [ 33 , 34 , 35 , 36 , 37 ].…”
Section: Methodsmentioning
confidence: 99%
“…Finally, in their excellent study, Zota el al. concluded that OSA is related to exercise limitation which is improved after continuous positive airway treatment [19].…”
Section: Introductionmentioning
confidence: 98%
“…Upper airway constriction is a multifactorial problem that can result from hypertrophic adenoids, a retrognathic mandible, atrophy of suprahyoid muscles especially lateral pterygoid and genioglossus muscle [ 22 ], obesity, as well as many other factors. Obstructive sleep apnea (OSA) is a common sleep disorder represented by repetitive nocturnal upper airway collapse accompanied by intermittent hypoxia, fragmented sleep, fluctuations in blood pressure and highly active sympathetic nervous system activity [ 23 , 24 ]. Sleep questionnaires and the number of apnea/hypopnea incidents per night determine the level of severity of OSA, measured by the apnea/hypopnea index (AHI) [ 25 , 26 ] assessed during Polysomnography (PSG), which is an important but costly and time-consuming tool for identifying OSA.…”
Section: Introductionmentioning
confidence: 99%