CPAP therapy improves erectile function in patients with severe obstructive sleep apnea

Schulz, Richard; Bischof, Fabian; Galetke, Wolfgang; Gall, Henning; Heitmann, J.; Hetzenecker, Andrea; Laudenburg, Markus; Magnus, Till Jonas; Nilius, Georg; Priegnitz, Christina; Randerath, Winfried; Schröder, M.; Treml, Marcel; Arzt, Michael

doi:10.1016/j.sleep.2018.03.018

Cited by 24 publications

(14 citation statements)

References 22 publications

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“…However, Schulz reported significant improvement in erectile function with CPAP treatment in men with moderate or severe ED based on IIEF. This evaluation of 94 patients with OSA prospectively used IIEF before and after 6-12 months of CPAP treatment[42]. Several other studies have come to similar conclusions.In a randomised study, Taskin et al demonstrated an increase of mean IIEF-5 score from 15.71 to 19.06 after at least one month of CPAP[26].…”

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confidence: 72%

Erectile Dysfunction and Obstructive Sleep Apnoea-What is the Link and What can We do about it? A Descriptive Review of the Current Literature

Polson¹,

Ralph²,

Kalejaiye³

2019

J Sleep Disord Ther

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Erectile dysfunction (ED) and obstructive sleep apnoea (OSA) are increasingly common conditions seen in primary and secondary care. With shared risk factors and associated comorbidities men often suffer with both. The aim of this study is to review the literature to consider why there is a correlation, and clinically how assessment and management of such patients could be adjusted. A structured review of current literature was performed using search terms 'erectile dysfunction' or 'erectile function' or 'Erection' or 'Sexual dysfunction' AND 'Sleep apnoea/apnea' or 'sleep disorder'. Descriptive analysis categorized results into: The association between OSA and ED; the pathophysiological hypotheses; the role of OSA treatment; and the role of ED treatment. Higher prevalence of ED in patients with OSA is demonstrated, particularly in men with more severe OSA disease, reaching 80% in some studies. However, the pathophysiological explanation remains unclear with a number of hypotheses researched. CPAP is the mainstay of treatment for OSA, and short and long-term benefits to sexual function are demonstrated in men with severe OSA from it's use. Further improvement in ED and quality of life can be achieved by additional PDE5 inhibitor therapy. With the increasing evidence base showing higher rates of ED in OSA patients there is certainly a role for clinicians in both OSA and ED clinics to enquire about each condition. A referral to their counterpart for consideration of combination treatment with CPAP and a PDE5 inhibitor for both of these problematic, life changing diseases is recommended-particularly in those with severe disease. Further investigation is needed to try and establish any pathophysiological link, and the impact of treatment in less severe cases.

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confidence: 72%

Erectile Dysfunction and Obstructive Sleep Apnoea-What is the Link and What can We do about it? A Descriptive Review of the Current Literature

Polson¹,

Ralph²,

Kalejaiye³

2019

J Sleep Disord Ther

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“…При наличии ЭД разные исследования подтверждают потенциальную пользу данного вида терапии. В одном из исследований около 100 больных с СОАС получали патогенетическое лечение, которое достоверно улучшило ЭФ у пациентов с умеренной и тяжелой ЭД по прошествии 6-12 мес лечения [100]. Положительные эффекты PAP-терапии на ЭФ становятся очевидными уже после нескольких дней лечения и достигают своего пика при продолжительном и эффективном ее использовании [101][102][103].…”

Section: синдром обструктивного апноэ сна и его роль в лечении аг и эдunclassified

Consensus of experts from the Russian Medical Society of Arterial Hypertension. Arterial hypertension and erectile dysfunction

et al. 2021

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Sexual health is an essential part of overall health, and an active and healthy sex life is an important aspect of a good quality of life. Cardiovascular diseases and sexual health disorders have common risk factors (arterial hypertension, diabetes mellitus, dyslipidemia, obesity and smoking) and common pathogenesis (endothelial dysfunction, inflammation and atherosclerosis). All this led to speculations about the pathophysiology and treatment options for sexual dysfunctions. The use of phosphodiesterase type 5 inhibitors has revolutionized the treatment of erectile dysfunction (ED) in men. This article focuses on ED and its relationship with hypertension. This document was created by experts from the Russian Medical Society of Arterial Hypertension with the participation of a member of the European Society of Hypertension Working Group on Sexual Dysfunction and Arterial Hypertension. In recent years, the expert group was very active in educating hypertension specialists and related specialties physicians about ED via numerous lectures at national and international congresses. It has been noted that ED precedes the development of coronary heart disease. The artery diameter hypothesis has been proposed as a possible explanation for this observation. Clinical manifestations of atherosclerotic lesions and/or endothelial dysfunction of the penile arteries may precede those in larger arteries. Patients with hypertension who receive antihypertensive drugs are more likely to suffer from sexual dysfunctions compared to untreated patients. The occurrence of ED appears to be related to the undesirable effects of antihypertensive drugs on the penile tissues. There is information about various effects of antihypertensive drugs on erectile function.

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“…Since then, CPAP therapy has become the most popular therapy for OSA because it ameliorates many adverse consequences of OSA. It is widely accepted that CPAP therapy reduces daytime sleepiness and risk of crashes, and improves quality of life, erectile function and systemic blood pressure (2,3).…”

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confidence: 99%

Physiology May Be the Key: Cardiovascular Risk Stratification in Obstructive Sleep Apnea

Singh

2021

Am J Respir Crit Care Med

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CPAP therapy improves erectile function in patients with severe obstructive sleep apnea

Cited by 24 publications

References 22 publications

Erectile Dysfunction and Obstructive Sleep Apnoea-What is the Link and What can We do about it? A Descriptive Review of the Current Literature

Erectile Dysfunction and Obstructive Sleep Apnoea-What is the Link and What can We do about it? A Descriptive Review of the Current Literature

Consensus of experts from the Russian Medical Society of Arterial Hypertension. Arterial hypertension and erectile dysfunction

Physiology May Be the Key: Cardiovascular Risk Stratification in Obstructive Sleep Apnea

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