CPMCP: a database of Chinese patent medicine and compound prescription

Abstract

Although several traditional Chinese medicine (TCM)-related databases have emerged, they focus on researching single medicinal materials, which is far from sufficient for clinical research and application. In comparison, compound prescriptions are more informative and meaningful in TCM, for they embody the information on the compatibility of TCM besides the relatively isolated information about single medicinal materials. The compatibility information is essential in TCM because it conveys not only what components are involved to treat special diseases but also how to combine these single medical materials. We established a database of Chinese patent medicine and compound prescription (CPMCP). It demonstrates the prescription information of Chinese patent medicines (CPMs) and ancient Chinese medicine prescriptions (CMPs). CPMCP reports their comprehensive and standardized information such as the components, indications and contraindications. It is worth mentioning that we organized relevant experts and spent lots of time manually mapping the functions of compound prescriptions in ancient Chinese to the standardized TCM symptom vocabularies, obtaining a total of 71 414 associations between compound prescriptions and TCM symptoms. In this way, CPMCP established the associations between TCM and modern medicine (MM) according to the associations between TCM symptoms and MM symptoms. In addition, to further exhibit the compatibility mechanism of compound prescriptions, CPMCP summarizes a set of common drug combination principles by analyzing the existing prescriptions. We believe that CPMCP can promote the modernization of TCM and make greater contributions to MM. Database URL http://cpmcp.top

TCMM: A Unified Database for Traditional Chinese Medicine Modernization and Therapeutic Innovations

“…TCMM is sourced from the 6 largest TCM knowledge bases, PrimeKG[39], PharMeBINet[40], TCMBank[13], SymMap[10], TCMID[32] and CPMCP[12], which results in a more detailed relations and a wider variety of entity types. In this work, the TCM or Western medical concepts, such as prescription, ingredient and target, are treated as entities.…”

“…SymMap[10] incorporates symptom information, which is beneficial for phenotype-based drug discovery research. LTM-TCM[11] and CPMCP[12] introduce the concept of prescription, which helps Chinese medicine practitioners understand the compatibility of herbs in prescriptions. TCMBANK[13] integrates a vast amount of data on herb, ingredient, disease, and target entities but neglects important concepts like prescription and symptom in the theoretical system of TCM.…”

Multi-level advances in databases related to systems pharmacology in traditional Chinese medicine: a 60-year review

“…Through analysis of existing TCM formulas, CPMCP has summarized frequently used herbal combinations in TCM clinical practice. This functionality has helped to uncover the habitual pairings and contraindications between various herbs, shedding light on principles of herbal compatibility ( Sun et al, 2022 ). Huabing data, an intelligent TCM big data platform, enables screening of disease-related formulas based on input herbal combinations.…”

“…HPO and DisGeNET are comprehensive databases for analyzing and interpreting human gene-disease networks ( Piñero et al, 2017 ; Köhler et al, 2021 , 1). CPMCP and SymMap also include both TCM symptoms and modern medicine (MM) symptoms in an attempt to bridge TCM and modern medicine-based research through symptom associations ( Wu et al, 2019 ; Sun et al, 2022 ).…”

A drug–drug cocrystal and a co-amorphous form, prepared from honokiol and ligustrazine, inspired by Chinese patent medicine

“…Modern honey pills are formed by a grinding machine. The binder is always traditional honey (Sun et al, 2022).…”