CPNE3 moderates the association between anxiety and working memory

Abstract

Mutual influences between anxiety and working memory (WM) have been extensively studied, and their curvilinear relationship resembles the classic Yerkes-Dodson law of arousal and performance. Given the genetic bases of both anxiety and WM, it is likely that the individual differences in the Yerkes-Dodson law of anxiety and WM may have genetic correlates. The current genome wide association study (GWAS) enrolled 1115 healthy subjects to search for genes that are potential moderators of the association between anxiety and WM. Results showed that CPNE3 rs10102229 had the strongest effect, p = 3.38E−6 at SNP level and p = 2.68E−06 at gene level. Anxiety and WM had a significant negative correlation (i.e., more anxious individuals performed worse on the WM tasks) for the TT genotype of rs10102229 (resulting in lower expression of CPNE3), whereas the correlation was positive (i.e., more anxious individuals performed better on the WM tasks) for the CC carriers. The same pattern of results was found at the gene level using gene score analysis. These effects were replicated in an independent sample (N = 330). The current study is the first to report a gene that moderates the relation between anxiety and WM and potentially provides a genetic explanation for the classic Yerkes-Dodson law.

Proteomic Profiling Reveals Specific Molecular Hallmarks of the Pig Claustrum

“…Goll et al [2] have proposed that CLA has the capacity to focus attention, an essential function for goal-direct behavior; besides, White et al [3] have provided data describing CLA as an anatomical and functional substrate that may underlie functions, such as executive attention or WM. Thus, such reported findings support our data regarding CPNE3 and, taken together, may indicate In psychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder, WM impairment is reported [83], and in this context, our data showing an overexpression of MBP in CLA are quite interesting. MBP is important in maintaining the structure of the myelin sheath [85].…”

YAP1-CPNE3 positive feedback pathway promotes gastric cancer cell progression

“…Understanding the physiological functions of CPNE3 would be beneficial for identifying adverse reactions. CPNE3 has been reported to have the following physiological functions: it protects the heart against ischemia/reperfusion injury [ 31 ], modifies the relationship between anxiety and working memory [ 32 ], regulates insulin secretion and glucose uptake in pancreatic cells [ 33 ]; and low CPNE3 expression is associated with an increased risk of acute myocardial infarction [ 34 ]. We performed cellular assays to determine the function of CPNE3 in gastric epithelial cells after downregulation of CPNE3 expression in GES-1 cells.…”

Parental warmth, stressful life events, and impulsivity: A gene–environment-wide interaction study.

“…Detailed procedures of genotyping for this data set were reported in previous publications (C. Chen et al, 2020Chen et al, , 2021. Briefly, DNA was extracted from blood samples and genotyped using Infinium chips (Illumina, San Diego, CA, USA) according to the manufacturer's specifications.…”

“…We have used that approach successfully to identify gene–environment interactions on cognition such as executive functions and working memory (C. Chen et al, 2020, 2021). The present study used the same GEWIS approach to study impulsivity.…”