cPSA and fPSA elimination in African-American men

Abstract

In all, 22 African-American males undergoing radical prostatectomy for prostate adenocarcinoma had serum drawn for tPSA, cPSA, and total protein concentrations prior to, during, and after operation to determine the respective elimination rates. African-American cPSA was found to fit best a simple first-order exponential elimination kinetic, with a half-life of 44.6 h. fPSA followed a two-compartment elimination with an a-phase elimination of 0.50 h and a b-phase half-life of 4.2 h. Our results suggest higher rates of elimination for both cPSA and fPSA in an African-American male population with respect to Caucasians and may account for differences in PSA values between races.

Circulating Prostate‐Specific Antigen and Telomere Length in a Nationally Representative Sample of Men Without History of Prostate Cancer

“…Our results also support strong effect modification in the association between total PSA and telomere length by race/ethnicity. PSA levels are known to be higher among African American compared to Caucasian men, which may be partly attributed to different rates of PSA metabolism . Our findings further underline the notion that the use of PSA screening requires understanding of how PSA is linked to specific tumor‐promoting pathways such as telomere length alteration, which may be able to explain the well‐known variation in clinical course and prognosis of the disease by race/ethnicity .…”

Absence of PSA Flare With Apalutamide Administered 1 Hour in Advance With GnRH Agonists: Case Report

“…The decrease in PSA on day 7 was consistent with 4 weeks of bicalutamide treatment ( 21 ), indicating a strong blocking effect of apalutamide. The half-life of PSA in human serum is approximately 3 days ( 27 , 28 ). The serum PSA of the first patient on apalutamide alone for 3 days was about two-thirds of that before treatment.…”

Increase in percent free prostate-specific antigen in men with chronic kidney disease

“…Half-life for fPSA in serum is short (4-33 h) [6][7][8][9][10]. This, combined with its low molecular mass, suggests elimination by glomerular filtration.…”