CQDs-Cross-Linked Conductive Collagen/PAA-Based Nanocomposite Organohydrogel Coupling Flexibility with Multifunctionality for Dual-Modal Sensing of Human Motions

Abstract

Conductive hydrogels are ideal materials for intelligent medical devices, human-machine interfaces, and flexible bioelectrodes due to their adjustable mechanical properties and electrical responsiveness, whereas it is still a great challenge to achieve the integration of excellent flexibility and biocompatibility into one hydrogel sensor while also incorporating self-healing, selfadhesion, environmental tolerance, and antimicrobial properties. Here, a nanocomposite conductive organohydrogel was constructed by using collagen (Col), alginate-derived carbon quantum dots (OSA-CQDs), poly(acrylic acid) (PAA), ethylene glycol reduced AgNPs, and Fe 3+ ions. Depending on OSA-CQDs with multiple chemical binding sites and high specific surface area as cross-linkers, while coupling highly biologically active Col chains and PAA chains are serving as an energy dissipation module, the resulting organohydrogel exhibited excellent flexibility (795% of strain, 193 kPa of strength), high cell compatibility (>95% survival rate), self-healing efficiency (HE = 79.5%), antifreezing (−20 °C), moisturizing (>120 h), repeatable adhesion (strength >20 kPa, times >10), inhibitory activity against Escherichia coli and Staphylococcus aureus (9 and 21.5 cm 2 ), conductivity, and strain sensitivity (σ = 1.34 S/m, gauge factor (GF) = 11.63). Based on the all-in-one integration of multifunction, the organohydrogel can collaboratively adapt to the multimode of strain sensing and electrophysiological sensing to realize wireless real-time monitoring of human activities and physiological health. Therefore, this work provides a new and common platform for the design and sensing of next-generation hydrogel-based smart wearable sensors.

Multifunctional, High-Strength Electronic Skin Based on the Natural Sheepskin Fiber Network for Multifaceted Human Health Monitoring and Management

“…Health problems have always significantly affected people’s quality of life. With the continuous development and progress of society, individual health management and disease prevention have gradually become topics of concern to everyone, and more and more studies have begun to focus on the hot spot of health monitoring. − The importance of health monitoring is that it can achieve early screening and early warning of diseases. , By monitoring the key physiological parameters of the body, potential health problems can be found in time, which is of great significance for preventing further deterioration of diseases, reducing complications, and improving the quality of life. Especially for chronic diseases, including high blood pressure and heart disease, continuous monitoring can keep the disease under control and avoid life-threatening conditions .…”

Multifunctional Biomimetic e-Skin Constructed In Situ on Tanned Sheep Leather as a Multimodal Sensor for the Monitoring of Motion and Health

“…With the advancement of flexible sensor devices, electronic skin (e-skin) has emerged as a cutting-edge technology that could emulate the structure and functionality of human skin and possess skin-like perception and response capabilities . In recent years, e-skin has found extensive applications in biosensing, , artificial intelligence, , bionic prosthetics, , personalized medical care, , among others. Currently, conductive hydrogels are widely employed as sensing materials for e-skin due to their excellent flexibility.…”