CR-19-0950: Event-related responses to alcohol-related stimuli in Mexican-American young adults: Relation to age, gender, comorbidity and “dark side” symptoms

Ehlers, Cindy L.; Phillips, Evelyn; Kim, Corinne; Wills, Derek N.; Karriker‐Jaffe, Katherine J.; Gilder, David A.

doi:10.1016/j.drugalcdep.2019.06.001

Cited by 5 publications

(6 citation statements)

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“…A history of adolescent extreme binge drinking was also associated with decreases in connectivity in all three cortical areas in response to sad facial expressions, as indexed by local phase locking. There have been a few studies that have evaluated ERO energy in specific frequency bands in individuals with alcohol-associated pathology (see [ 36 , 38 , 39 , 55 , 56 , 58 , 59 , 120 ]. In two sets of studies, it was demonstrated that both alcoholics [ 66 , 120 ] and young offspring of alcoholics at high risk for alcohol use disorders [ 67 ], show decreases in delta oscillations to target stimuli during a visual oddball task.…”

Section: Discussionmentioning

confidence: 99%

“…Reduced amplitude of the P300 or P3 component of the event-related potential (ERP) has perhaps received the most attention as a possible biomarker for AUD risk [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ]. Several studies have recently applied time-frequency techniques, such as event-related oscillations (EROs), to ERP data in order to develop additional measures of alcohol-related psychopathology [ 36 , 38 , 55 , 56 , 57 , 58 , 59 ]. The application of ERO analyses can generate information on the amount of energy in different frequency sub-bands (such as delta, theta, alpha, and beta activity) that may contribute to the ERP waveform.…”

Section: Introductionmentioning

confidence: 99%

“…ERO energy measures, in different frequency sub-bands, have also been applied to the investigation of alcohol-related psychopathology [ 36 , 38 , 39 , 55 , 56 , 57 , 58 , 59 , 65 ]. For instance, it has been demonstrated that both alcoholics [ 66 ] and young offspring of alcoholics, who are at high risk for alcohol use disorders [ 67 ], show decreases in delta oscillations in response to target stimuli during a visual oddball task.…”

Section: Introductionmentioning

confidence: 99%

“…Neural phase locking can be measured over time within a local neuronal population (‘local synchrony’) or between distant populations (‘long-range synchrony’) [ 76 , 77 ], and thus represents a process whereby communication can effectively occur either within a brain area or between brain areas. ERO synchrony measures have been demonstrated to be a sensitive index of brain development over the course of adolescence in humans and rodents [ 78 ] as well as a potential measure of risk for AUD [ 57 , 59 ]. Thus, measures of neuronal energy and phase synchrony, within specific frequency bands, may also represent possible biomarkers of adolescent extreme binge drinking as well as concomitant suicide risk.…”

Section: Introductionmentioning

confidence: 99%

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Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk

Ehlers

Wills

Karriker‐Jaffe

et al. 2020

Behavioral Sciences

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Alcohol exposure typically begins in adolescence, and heavy binge drinking is associated with health risk behaviors. Event-related oscillations (EROs) may represent sensitive biomarkers or endophenotypes for early alcohol exposure as well as other risk behaviors such as suicidal thoughts and actions. In this study, young adults (age 18–30 years) of American Indian (AI) (n = 479) and Mexican American (MA) (n = 705) ancestry were clinically assessed, and EROs were generated to happy, sad and neutral faces. Extreme adolescent binge drinking (10+ drinks) was common (20%) in this population of AI/MA and associated with a significantly increased risk of a lifetime history of suicidal acts (SA, suicide attempts, deaths) but not suicidal thoughts (ST, ideation, plans). ST were reported among MA participants, whereas SA were more common among AI young adults. Extreme adolescent binge drinking was also associated with errors in detection of sad and neutral faces, increases in delta ERO energy, and decreases in phase locking (PL), particularly in parietal areas. A lifetime history of ST was associated with increases in delta ERO energy and PL, whereas SA were associated with decreases in both. These studies suggest that ERO measures may represent important potential biomarkers of adolescent extreme binge drinking and risk for suicidal behaviors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk

Ehlers

Wills

Karriker‐Jaffe

et al. 2020

Behavioral Sciences

Self Cite

View full text Add to dashboard Cite

show abstract

“…Electrophysiological variables may represent sensitive biomarkers of vulnerability to, or endophenotypes for, AUD ( 8 ). Event-related potentials (ERPs) are averaged scalp electroencephalography responses time-locked to specific events in a sensory, motor, or cognitive task.…”

Section: Introductionmentioning

confidence: 99%

The Association of P300 Components With Clinical Characteristics and Efficacy of Pharmacotherapy in Alcohol Use Disorder

Yuan

Wu³

et al. 2022

Front. Psychiatry

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PurposeThe purpose of this study is to explore the association of P300 components with clinical characteristics and efficacy of pharmacotherapy in alcohol use disorder (AUD).MethodsOne hundred fifty-one AUD patients and 96 healthy controls were recruited and evaluated for the symptoms of depression, anxiety, sleep, and cognitive function by the Alcohol Use Disorders Identification Test (AUDIT), the 9-item Patient Health Questionnaire (PHQ-9), the 7-item Generalized Anxiety Disorder scale (GAD-7), the Pittsburgh Sleep Quality Index (PSQI), Digit Symbol Substitution test (DSST), and event-related potential P300, which is one of the averaged scalp electroencephalography responses time-locked to specific events. Among the AUD group, 101 patients finished an 8-week pharmacotherapy and were evaluated for the above data at post-intervention.Results1. At baseline, AUD patients had higher scores of AUDIT, PHQ-9, GAD-7, PSQI, and P300 latency at Cz, Pz, and Fz and lower DSST score and smaller P300 amplitudes at Fz, Cz, and Pz compared with controls. P300 components correlated significantly with alcohol dose and score of AUDIT, PHQ-9, GAD-7, PSQI, and DSST. 2. After 8 weeks' treatment, there were significant changes for the P300 components; alcohol dose; and score of AUDIT, PHQ-9, GAD-7, PSQI, and DSST. Variables at baseline, including P300 amplitudes at Fz, Cz, and Pz; latency of Fz and Pz; alcohol dose; and scores of PHQ-9, GAD-7, PSQI, and DSST, were significantly associated with changes of reduction rate of AUDIT scores. However, P300 amplitudes at Fz, Cz, and Pz in AUD patients after 8-week treatment were still significantly shorter than healthy controls (HCs), and P300 latencies at Fz, Cz, and Pz were significantly longer than HCs. 3. When validated area under the receiver operating characteristic curve (AUC) was over 0.80, the baseline variables including amplitudes at Cz and Pz, alcohol dose, and scores of PSQI could predict the changes of reduction rate of AUDIT score.ConclusionP300 amplitudes and latencies at Fz, Cz, and Pz could be used as biological markers for evaluating the clinical characters and severity of AUD. P300 amplitudes at Cz and Pz, sleep condition, and cognitive function at baseline could predict the efficacy of pharmacotherapy for AUD patients.

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Protective effects of ethnic enclaves: Testing pathways to alcohol use and use disorders in Mexican American young adults

Tam,

Li,

Kosai

et al. 2024

American J of Comm Psychol

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Ethnic enclave residence is associated with decreased risk for drinking and related problems, but less is known about the mechanisms that explain this association. Informed by theories of social control, we used a multilevel framework to examine whether negative attitudes toward drinking mediated associations between ethnic enclave residence (i.e., neighborhood linguistic isolation) and alcohol outcomes among Mexican American young adults (N = 628) in Southern California. Model 1 assessed mediation effects in the pathways from linguistic isolation to current drinking and alcohol use disorder (AUD). Model 2 adjusted for parental drinking attitudes and neighborhood alcohol availability. There were differential associations by gender in direct effects of linguistic isolation and negative drinking attitudes on both drinking and AUD. Among women only, linguistic isolation was related to greater abstinence and decreased AUD after accounting for social control proxies of parent attitudes and alcohol availability. Young adults' own drinking attitudes did not mediate relationships between linguistic isolation and alcohol outcomes. This study offers evidence on the importance of disaggregating Hispanic national groups by gender to uncover social mechanisms within ethnic enclave settings for tailored supports in reducing risk of drinking and alcohol‐related harms.

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CR-19-0950: Event-related responses to alcohol-related stimuli in Mexican-American young adults: Relation to age, gender, comorbidity and “dark side” symptoms

Cited by 5 publications

References 98 publications

Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk

Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk

The Association of P300 Components With Clinical Characteristics and Efficacy of Pharmacotherapy in Alcohol Use Disorder

Protective effects of ethnic enclaves: Testing pathways to alcohol use and use disorders in Mexican American young adults

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