Cr:Forsterite‐laser‐based fiber‐optic nonlinear endoscope with higher efficiencies

Chan, Ming-Che; Chu, Shi‐Wei; Tseng, Chien Hung; Wen, Yu-Chieh; Chen, Yi Hsien; Su, Guo-Dung John; Sun, Chi‐Kuang

doi:10.1002/jemt.20586

Cited by 7 publications

(3 citation statements)

References 30 publications

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“…As much as 2W CW and 1.4W average output power of sub-100fs pulses were thus demonstrated at 267K. Our study indicates the capability of a Cr:forsterite laser cavity to directly produce stable and high average power femtosecond pulse trains, which will open many biophotonics [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]24,25], spectroscopy, and telecommunication [23] applications.…”

Section: Introductionmentioning

confidence: 91%

“…In telecommunication and fiber-based system, the optical pulses in this spectral regime will not broaden significantly as they propagate in an optical fiber. This is of particular importance in both telecommunication system [23] and nonlinear light fibermicroscopy [20,24,25]. Combining with a photonic crystal fiber (PCF), intense Cr:forsterite femtosecond pulses can achieve a super-continuum (SC) white light source with a pulse energy of 1.15μJ [26,27] and broadest ever soliton self-frequency shift to 2.2μm [28], which is a simple widely-tunable source for various ultrafast applications, including large-dynamicrange RF phase shifter [29].…”

Section: Introductionmentioning

confidence: 99%

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A sub-100fs self-starting Cr:forsterite laser generating 14W output power

et al. 2010

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Without cavity dumping or external amplification, we report a femtosecond Cr:forsterite laser with a 1.4 W output power and 2 W in continuous wave (CW) operated with a crystal temperature of 267 K. In the femtosecond regime, the oscillator generates Kerr-lens-mode-locked 84 fs pulses with a repetition rate of 85 MHz, corresponding to a high 16.5 nJ pulse energy directly from a single Cr:forsterite resonator. This intense femtosecond Cr:forsterite laser is ideal to pump varieties of high power fiber light sources and could be thus ideal for many biological and spectroscopy applications.

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Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

A sub-100fs self-starting Cr:forsterite laser generating 14W output power

et al. 2010

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“…To avoid these problems, several groups are using laser sources with wavelengths longer than 1,200 nm. Cr:Forsterite laser at excitation wavelength of 1,230 nm and repetition rate of 110 MHz is widely used (Chan et al, 2008; Chu et al, 2001). Other lasers include optical parametric oscillators (OPO) working at the wavelength of 1,500 nm and repetition rate of ∼80 MHz (Canioni et al, 2001); optical parametric amplifiers at 1,200 nm and 250 kHz repetition rate pumped by a Ti:sapphire laser (Squier et al, 1998); and fiber lasers at 1,560 nm with repetition rate of 50 MHz (Millard et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Harmonic optical microscopy and fluorescence lifetime imaging platform for multimodal imaging

Pelegati

Adur

Thomaz

et al. 2012

Microscopy Res & Technique

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In this work, we proposed and built a multimodal optical setup that extends a commercially available confocal microscope (Olympus VF300) to include nonlinear second harmonic generation (SHG) and third harmonic generation (THG) optical (NLO) microscopy and fluorescence lifetime imaging microscopy (FLIM). We explored all the flexibility offered by this commercial confocal microscope to include the nonlinear microscopy capabilities. The setup allows image acquisition with confocal, brightfield, NLO/multiphoton and FLIM imaging. Simultaneously, two-photon excited fluorescence (TPEF) and SHG are well established in the biomedical imaging area, because one can use the same ultrafast laser and detectors set to acquire both signals simultaneously. Because the integration with FLIM requires a separated modulus, there are fewer reports of TPEF+SHG+FLIM in the literature. The lack of reports of a TPEF+SHG+THG+FLIM system is mainly due to difficulties with THG because the present NLO laser sources generate THG in an UV wavelength range incompatible with microscope optics. In this article, we report the development of an easy-to-operate platform capable to perform two-photon fluorescence (TPFE), SHG, THG, and FLIM using a single 80 MHz femtosecond Ti:sapphire laser source. We described the modifications over the confocal system necessary to implement this integration and verified the presence of SHG and THG signals by several physical evidences. Finally, we demonstrated the use of this integrated system by acquiring images of vegetables and epithelial cancer biological samples.

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