Using an elastodynamic boundary integral formulation coupled with a cohesive model, we study the problem of a dynamic rupture front propagating along an heterogeneous plane. We show that small-scale heterogeneities facilitate the supershear transition of a mode-II crack. The elastic pulses radiated during front accelerations explain how microscopic variations of fracture toughness change the macroscopic rupture dynamics. Perturbations of dynamic fronts are then systematically studied with different microstructures and loading conditions. The process zone size is the intrinsic length scale controlling heterogeneous dynamic rupture. The ratio of this length scale to asperity size is proposed as an indicator to transition from quasihomogeneous to heterogeneous fracture. Moreover, we discuss how the shortening of the process zone size with increasing crack speed brings the front to interact with smaller details of the microstructure. This study shines new light on recent experiments reporting perturbations of dynamic rupture fronts, which intensify with crack propagation speed. DOI: 10.1103/PhysRevLett.119.144101 Introduction.-Our modern understanding of fracture arose from Griffith [1] and Irwin [2] which viewed crack propagation as a thermodynamic process where, at equilibrium, the energetic cost of creating new surfaces in the material is balanced by the release of strain energy subsequent to crack advance. This theoretical framework known as linear elastic fracture mechanics (LEFM) has been successfully used over the last 50 years to predict the stability of flaws in engineering materials. Consequently LEFM was extended to cracked bodies far from equilibrium, i.e., to dynamic fracture mechanics [3,4]. Experiments on brittle solids showed that this dynamic theory of fracture gives good prediction for slow crack propagation but is unsuitable to describe fast rupture events where the crack front speed is a significant fraction of material shear wave speed c s . In particular, linear elastic theory overestimates the propagation speed and significantly underestimates the dissipated energy. For a review of dynamic fracture experiments, the reader is referred to [5][6][7][8][9]. A three-stage transition is universally observed within brittle materials, usually referred to as "mirror," "mist," and "hackle" in reference to the postmortem appearance of fracture surface. At low rupture velocity, fracture surfaces are planar and smooth (mirror) and crack dynamics is thereby well predicted by LEFM theory. As crack speed increases, the rupture remains in plane but fracture surface roughens (mist), followed by a stage characterized by the formation of out-of-plane microbranches (hackle), and finally the onset of macroscopic branching. This transition observed in various brittle materials [7,10] and at different scales [11,12] explains how linear elasticity fails at describing fast rupture events where the front starts to interplay with the microstructure and/or dynamic instabilities