Today’s societal challenges require rapid response and smart materials solutions in almost all technical areas. Driven by these needs, data-driven research has emerged as an enabler for faster innovation cycles. In fields such as chemistry, materials science and life sciences, automatic and even autonomous data generation and processing is already accelerating knowledge discovery. In contrast, in experimental mechanics, complex investigations like studying fatigue crack growth in structural materials have traditionally adhered to standardized procedures with limited adoption of the digital transformation. In this work, we present a novel infrastructure for data-centric experimental mechanics in the field of fatigue crack growth. Our methodology incorporates a robust code base that complements a multi-scale digital image correlation and robot-assisted test rig. Using this approach, the information-to-cost ratio of fatigue crack growth experiments in aerospace materials is significantly higher compared to traditional experiments. Thus, serves as a catalyst for discovering new scientific knowledge in the field of structural materials and structures.