Cracking the Role of Cocaine in Stroke

Merenda, Amedeo; Muir, Keith W.; Koch, Sebastian

doi:10.1161/strokeaha.116.012681

Cited by 3 publications

(1 citation statement)

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“…This mechanism may trigger transient cardiac ischemia resulting in partial or global ventricular wall abnormality far better than any other stimulant drug due to its unique lipophilic efficiency. [15] Cocaine may cause platelet activation, a-granule release, and platelet containing microaggregate formation producing a prothrombogenic state and predisposition to ischemic events. This mechanism is likely responsible for both middle and posterior cerebral artery strokes in our patient, given his long-standing cocaine use.…”

Section: Discussionmentioning

confidence: 99%

Cocaine-induced massive ischemic stroke treated by decompressive craniectomy with favorable outcome

et al. 2021

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Cocaine abuse is a significant health hazard with multiple cardiac and neurological complications. Cocaine-induced ischemic stroke can have multiple underlying pathophysiological mechanisms, resulting in various complex neurological presentations. We describe a case of a young man who had a massive ischemic multi-territorial stroke who was managed successfully with decompressive craniectomy with a favorable outcome. Cocaine use should be routinely suspected in young patients presenting with ischemic stroke, and a urine toxicology screen should be part of the initial workup for such patients. Brain magnetic resonance imaging is an essential neuroimaging modality, which is very helpful in confirming the ischemic insult and planning management. Early diagnosis and treatment are crucial due to potential reversibility and reduction of the size of infarcted tissue. In addition, multidisciplinary care, including a vascular neurosurgeon, should be implicated.

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Section: Discussionmentioning

confidence: 99%

Cocaine-induced massive ischemic stroke treated by decompressive craniectomy with favorable outcome

et al. 2021

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Stroke and Substance Abuse

Brust¹

2022

Stroke

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Ictus por consumo de tóxicos inicialmente no reconocido

Andrés¹,

García²,

Navarro³

et al. 2019

Atención Familiar

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<p>El consumo excesivo de cocaína es un problema de salud pública en el mundo, dicho consumo representa un reto para los sistemas clínicos y hospitalarios debido al impacto que tiene a nivel cardiovascular en los consumidores. En el presente escrito se aborda el caso de un varón de 46 años con debilidad en el hemicuerpo izquierdo, que refiere haber consumido únicamente tabaco como sustancia tóxica; posterior al estudio clínico, pero en pruebas complementarias, se determina la presencia de vasoespasmo severo inducido por cocaína.</p>

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Cracking the Role of Cocaine in Stroke

Cited by 3 publications

References 1 publication

Cocaine-induced massive ischemic stroke treated by decompressive craniectomy with favorable outcome

Cocaine-induced massive ischemic stroke treated by decompressive craniectomy with favorable outcome

Stroke and Substance Abuse

Ictus por consumo de tóxicos inicialmente no reconocido

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