Cranberries – potential benefits in patients with chronic kidney disease

Alvarenga, Livia; Borges, Natália Alvarenga; Moreira, Laís de Souza Gouveia; Teixeira, Karla Thaís Resende; Carraro-Eduardo, José Carlos; Dai, Lu; Stenvinkel, Peter; Lindholm, Bengt; Mafra, Denise

doi:10.1039/c9fo00375d

Cited by 28 publications

(18 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A range of studies have identified optimized nutrition as one of the best strategies to prevent or reduce the complications in CKD. For example, cranberry consumption known historically as a strategy to treat urinary tract infections, can also be used to decrease inflammation and oxidative stress in CKD (De Almeida Alvarenga et al, 2019). Brazilian açai fruit has also been suggested as a food with anti-inflammatory and anti-oxidant action, and is a rich source of flavonoids (Martins et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

The sweet side of dark chocolate for chronic kidney disease patients

et al. 2021

Self Cite

View full text Add to dashboard Cite

Chocolate is a widely appreciated foodstuff with historical appreciation as a food from the gods. In addition to its highly palatable taste, it is a rich source of (poly)phenolics, which have several proposed salutogenic effects, including neuroprotective antiinflammatory, anti-oxidant and cardioprotective capabilities . Despite the known benefits of this ancient foodstuff, there is a paucity of information on the effects of chocolate on in the context of chronic kidney disease (CKD). This review focusses on the potential salutogenic contribution of chocolate intake, to mitigate inflammatory and oxidative burden in CKD, its potential,, for cardiovascular protection and on the maintenance of diversity in gut microbiota, as well as clinical perspectives, on regular chocolate intake by CKD patients.

show abstract

Section: Introductionmentioning

confidence: 99%

The sweet side of dark chocolate for chronic kidney disease patients

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Many Vaccinium species are utilized as medicinal plants and ornamental landscape ground cover [5]. The high phenolic compounds having strong antioxidative properties of Vaccinium berries are linked to the prevention of several chronic and degenerative diseases including cancer and cardiovascular disorders [6]. The principle function of those antioxidants is to stop or delay the oxidation of other molecules through inhibiting the initiation or propagation of oxidizing chain reactions by free radicals.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Propagation and Variation of Antioxidant Properties in Micropropagated Vaccinium Berry Plants—A Review

Debnath

Goyali

2020

Molecules

View full text Add to dashboard Cite

The berry crops in genus Vacciniun L. are the richest sources of antioxidant metabolites which have high potential to reduce the incidence of several degenerative diseases. In vitro propagation or micropropagation has been attractive to researchers for its incredible potential for mass production of a selected genotype in a short time, all year round. Propagation techniques affect the antioxidant activity in fruits and leaves. Total antioxidant activity was higher in the fruit of in vitro propagated plants compare to the plants grown ex vivo. This review provides critical information for better understanding the micropropagation and conventional propagation methods, and their effects on antioxidant properties and morphological differentiation in Vaccinium species, and fills an existing gap in the literature.

show abstract

“…A 2 week CJ supplementation study with 7 mL/kg bodyweight given to men, increased plasma AC and decreased oxidized LDL levels, a heart disease risk factor [29]. It is also of importance that the cranberry anthocyanin metabolites accumulate in the kidney and bladder since cranberry and especially CJ are well known to benefit urinary tract health [30]. The fact that PP metabolites also get into other organs such as the prostate [31], brain and liver are significant as growing evidence that cranberries may have a role in cancer prevention and treatment [32].…”

Section: Discussionmentioning

confidence: 99%

Pure Polyphenols and Cranberry Juice High in Anthocyanins Increase Antioxidant Capacity in Animal Organs

Bariexca

Ezdebski

Redan

et al. 2019

Foods

View full text Add to dashboard Cite

Anthocyanins and the broader class of polyphenols are strong antioxidants in vitro. Polyphenols are one of the major antioxidants in plant foods, and the beverages derived from them. There is extensive evidence in the literature that polyphenols are beneficial to health. In order to be bioactive in vivo, they need to be bioavailable and be transported from the circulation to target organs. To date, there have been few studies testing the extent to which polyphenols and especially anthocyanins affect the antioxidant capacity of animal organs. In our first pilot study, we investigated how three pure polyphenols (the flavonoids quercetin, catechin and hesperetin) given to rats by intraperitoneal injection (49 to 63 mg/kg) affected their organ antioxidant capacity. This was followed by a subsequent study that injected one ml of 100% cranberry juice (high in anthocyanins) to hamsters. Antioxidant capacity of animal organs was determined by using the ferric reducing antioxidant power (FRAP) colorimetric assay on methanolic extracts of select rat organs (i.e., liver, kidney, heart, prostate and brain) and in the hamster organs (i.e., liver, kidney, heart, bladder and brain). Overall the results showed that antioxidant capacity was significantly increased (p < 0.05) in experimental vs. control organs. Analysis of organs by high performance liquid chromatography (HPLC) from both animal studies provided evidence of polyphenol metabolites in the organ extracts. Taken together, this study provides data that the administration of anthocyanins and other polyphenols cause an increase in organ antioxidant capacity in two animal models. This result supports the growing evidence for the hypothesis that dietary polyphenols reduce the risk and extent of various chronic disease at the disease site.

show abstract

Cranberries – potential benefits in patients with chronic kidney disease

Abstract: Patients with chronic kidney disease (CKD) present many complications that potentially could be linked to increased cardiovascular mortality such as inflammation, oxidative stress, cellular senescence and gut dysbiosis.

Cited by 28 publications

References 98 publications

The sweet side of dark chocolate for chronic kidney disease patients

The sweet side of dark chocolate for chronic kidney disease patients

In Vitro Propagation and Variation of Antioxidant Properties in Micropropagated Vaccinium Berry Plants—A Review

Pure Polyphenols and Cranberry Juice High in Anthocyanins Increase Antioxidant Capacity in Animal Organs

Contact Info

Product

Resources

About