Cranberry high molecular weight constituents promote Streptococcus sobrinus desorption from artificial biofilm

Steinberg, Doron; Feldman, Mark; Ofek, Itzhak; Weiss, Ervin I.

doi:10.1016/j.ijantimicag.2004.10.014

Cited by 62 publications

(32 citation statements)

References 23 publications

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“…The plaque and biofilm formation leads to caries and subsequently leads to periodontal disease if left untreated. Constituents of cranberry were demonstrated to decrease the hydrophobicity of streptococcal species [12, 16]. Cranberry high-molecular-weight component was shown to inhibit secretion of glucosyl and fructosyltransferases by oral streptococci [12] and coaggregation of bacteria [12].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that relatively high concentrations of NDM (e.g., 0.5–2 mg/mL) were required to cause 80% or more reduction of biofilm formation by S. mutans on saliva-coated HA [16] and by P. gingivalis on polystyrene surfaces [7]. In the present study, we show that lower concentrations of NDM (0.05–0.1 mg/mL) selectively inhibited the metabolic activity of oral bacteria, S. gordonii .…”

Section: Discussionmentioning

confidence: 99%

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Inhibition ofStreptococcus gordoniiMetabolic Activity in Biofilm by Cranberry Juice High-Molecular-Weight Component

Babu

Blair

Shiloah

et al. 2012

Journal of Biomedicine and Biotechnology

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Previous studies demonstrated that a cranberry high-molecular-mass, nondialyzable material (NDM) can inhibit adhesion of numerous species of bacteria and prevents bacterial coaggregation of bacterial pairs. Bacterial coaggregation leads to plaque formation leading to biofilm development on surfaces of oral cavity. In the present study, we evaluated the effect of low concentrations of NDM onStreptococcus gordoniimetabolic activity and biofilm formation on restorative dental surfaces. We found that the NDM selectively inhibited metabolic activity ofS. gordonii, without affecting bacterial viability. Inhibiting the metabolic activity of bacteria in biofilm may benefit the health of the oral cavity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inhibition ofStreptococcus gordoniiMetabolic Activity in Biofilm by Cranberry Juice High-Molecular-Weight Component

Babu

Blair

Shiloah

et al. 2012

Journal of Biomedicine and Biotechnology

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“…These agents seemed very effective in removing dental plaque, but excessive dosage use can result in alteration of the oral cavity and also the development of bacterial tolerance. The routine use of chlorhexidine gluconate at high concentrations as part of daily oral hygiene is particularly unsafe and sensitive against mutans streptococci (Ernst et al, 1998;Steinberg et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

In vitro anti‐biofilm activity of macelignan isolated from Myristica fragrans Houtt. against oral primary colonizer bacteria

Yanti

Rukayadi

Kim

et al. 2007

Phytotherapy Research

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In early dental plaque formation, oral primary colonizers such as Streptococcus mutans, Streptococcus sanguis and Actinomyces viscosus are initially attached to the pellicle-coated tooth surface to form a biofilm. The study aimed to determine the efficacy of macelignan, isolated from nutmeg (Myristica fragrans Houtt.), in removing each single oral primary biofilm in vitro on a polystyrene 96-well microtiter plate. Four biofilm growth phases (4, 12, 20 and 24 h) were evaluated in this study after treatment with macelignan at various concentrations (0.2, 2 and 10 microg/mL) and exposure times (5, 10 and 30 min). Anti-biofilm activity of macelignan was measured as the percentage of the remaining biofilm absorbance after macelignan treatment in comparison with the untreated control. At 24 h of biofilm growth, S. mutans, A. viscosus and S. sanguis biofilms were reduced by up to 30%, 30% and 38%, respectively, after treatment with 10 microg/mL macelignan for 5 min. Increasing the treatment time to 30 min resulted in a reduction of more than 50% of each of the single primary biofilms. The results indicate that macelignan is a potent natural anti-biofilm agent against oral primary colonizers.

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“…The positive health benefits of cranberries and cranberry derived constituents include improvements of cardiovascular function as measured by decreases in lipid peroxidation, oxidative stress, total and low-density lipoprotein (LDL} cholesterol and high-density lipoprotein (HDL) cholesterol level increases [1,2]. Cranberry derived products can also increase immune function by increasing γδ-T cells, NK cells and B-cells [3], as well as exhibit antimicrobial and anti-adhesion activities against Gram-positive bacteria [4], Gram-negative bacteria [5][6][7][8][9][10][11] and yeast [12,13]. Utilization of cranberry and cranberry derived constituents in the prevention of cancer is an underexplored area, but one with mounting preclinical in vitro and in vivo research as will be reviewed herein.…”

Section: Introductionmentioning

confidence: 99%

Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents

Weh

Clarke

Kresty

2016

Preprint

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Abstract:Cranberries are rich in bioactive constituents reported to influence a variety of health benefits, ranging from improved immune function and decreased infections to reduced cardiovascular disease and more recently cancer inhibition. A review of cranberry research targeting cancer revealed positive effects of cranberries or cranberry derived constituents against 17 different cancers utilizing a variety of in vitro techniques, whereas in vivo studies supported the inhibitory action of cranberries toward cancers of the esophagus, stomach, colon, bladder, prostate, glioblastoma and lymphoma. Mechanisms of cranberry-linked cancer inhibition include cellular death induction via apoptosis, necrosis and autophagy; reduction of cellular proliferation; alterations in reactive oxygen species; and modification of cytokine and signal transduction pathways. Given the emerging positive preclinical effects of cranberries, future clinical directions targeting cancer or premalignancy in high risk cohorts should be considered.

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Cranberry high molecular weight constituents promote Streptococcus sobrinus desorption from artificial biofilm

Cited by 62 publications

References 23 publications

Inhibition ofStreptococcus gordoniiMetabolic Activity in Biofilm by Cranberry Juice High-Molecular-Weight Component

Inhibition ofStreptococcus gordoniiMetabolic Activity in Biofilm by Cranberry Juice High-Molecular-Weight Component

In vitro anti‐biofilm activity of macelignan isolated from Myristica fragrans Houtt. against oral primary colonizer bacteria

Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents

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