Cranberry Juice Increases Antioxidant Status Without Affecting Cholesterol Homeostasis in Orchidectomized Rats

Deyhim, Farzad; Patil, Bhimanagouda S.; Villarreal, Arnulfo; Lopez, Erica; Garcia, Kristi; Rios, Ryan; García, Claudia; Gonzales, Cheri; Mandadi, Kranthi K.

doi:10.1089/jmf.2006.218

Cited by 27 publications

(20 citation statements)

References 41 publications

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“…In contrast, SOD1 null-mutants of flies conferred a hypersensitivity to paraquat and had a reduced longevity (Phillips et al, 1989;Sun et al, 2012). The up-regulation of SOD1 observed in the present study was consistent with the previous report of Deyhim et al (2007), who demonstrated that cranberry supplementation was associated with a higher SOD activity in orchidectomized rats. Secondly, the lifespan prolonging activity of CrA was also likely associated with down-regulation of MTH, InR, TOR and PEPCK (Fig.…”

Section: Discussionsupporting

confidence: 92%

Cranberry anthocyanin extract prolongs lifespan of fruit flies

Wang

Lei

et al. 2015

Experimental Gerontology

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Section: Discussionsupporting

confidence: 92%

Cranberry anthocyanin extract prolongs lifespan of fruit flies

Wang

Lei

et al. 2015

Experimental Gerontology

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“…Therefore, we assume that neither carbohydrate content nor additional calories of cranberry powder may be main factors affecting synthesis of hepatic triglyceride. Similarly, in a study reported by Deyhim et al [36], drinking cranberry juice for a period of four months resulted in an increase in plasma triglyceride concentration even though hepatic triglyceride level was decreased in orchidectomized rats. Findings of this study suggested that cranberry juice has abundant bioactive anthocyanins and flavonoids; however, it did not have an effect on circulating triglyceride homeostasis regardless of hepatic clearance of triglyceride.…”

Section: Discussionmentioning

confidence: 66%

Effects of cranberry powder on biomarkers of oxidative stress and glucose control indb/dbmice

et al. 2013

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Increased oxidative stress in obese diabetes may have causal effects on diabetic complications, including dyslipidemia. Lipopolysccharides (LPS) along with an atherogenic diet have been found to increase oxidative stress and insulin resistance. Cranberry has been recognized as having beneficial effects on diseases related to oxidative stress. Therefore, we employed obese diabetic animals treated with an atherogenic diet and LPS, with the aim of examining the effects of cranberry powder (CP) on diabetic related metabolic conditions, including lipid profiles, serum insulin and glucose, and biomarkers of oxidative stress. Forty C57BL/KsJ-db/db mice were divided into the following five groups: normal diet + saline, atherogenic diet + saline, atherogenic diet + LPS, atherogenic diet + 5% CP + LPS, and atherogenic diet + 10% CP + LPS. Consumption of an atherogenic diet resulted in elevation of serum total cholesterol and atherogenic index (AI) and reduction of high density lipoprotein (HDL)-cholesterol. However, with 10% CP, the increase in mean HDL-cholesterol level was close to that of the group with a normal diet, whereas AI was maintained at a higher level than that of the group with a normal diet. LPS induced elevated serum insulin level was lowered by greater than 60% with CP (P < 0.05), and mean serum glucose level was reduced by approximately 19% with 5% CP (P > 0.05). Mean activity of liver cytosolic glutathione peroxidase was significantly increased by LPS injection, however it was reduced back to the value without LPS when the diet was fortified with 10% CP (P < 0.05). In groups with CP, a reduction in mean levels of serum protein carbonyl tended to occur in a dose dependent manner. Particularly with 10% CP, a reduction of approximately 89% was observed (P > 0.05). Overall results suggest that fortification of the atherogenic diet with CP may have potential health benefits for obese diabetes with high oxidative stress, by modulation of physical conditions, including some biomarkers of oxidative stress.

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“…Similarly, Duthie et al (2006) found that plasma SOD activities were not different between cranberry juice consumption and placebo groups. However, there was a conflict finding observed in a study by Deyhim et al (2007), which reported that cranberry juice increased plasma SOD activity. For biomarkers of protein and lipid oxidation, mean serum protein carbonyl and TBARS levels were significantly decreased in 5% cranberry powder treated group compared with atherogenic diet fed group in this study.…”

Section: Discussionmentioning

confidence: 90%

“…In the current study, we also observed similar results that serum total cholesterol and LDL-cholesterol levels were not significantly different in rats with and without cranberry powder treatment, but serum HDL-cholesterol level was significantly increased by 5% cranberry powder fortification. Deyhim et al (2007) also reported that drinking cranberry juice increased plasma antioxidant capacity but did not change the cholesterol concentrations in liver and plasma of rat and it assumed that cranberry juice might increase antioxidant status without affecting cholesterol homeostasis.…”

Section: Discussionmentioning

confidence: 99%

“…In a human intervention study with the dried cranberry juice, serum protein oxidation level was significantly decreased by a 1200 mg of dried cranberry juice consumption (Valentova et al, 2007). Deyhim et al (2007) reported that cranberry juice increased plasma antioxidant capacity and reduced malondialdehyde concentrations. Vattem et al (2005) also reported that cranberry phenolics decreased MDA formation in oxidatively stressed porcine muscle and it suggested that exogenously treated phenolic phytochemicals could be reducing the oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

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Effects of cranberry powder on serum lipid profiles and biomarkers of oxidative stress in rats fed an atherogenic diet

et al. 2008

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This study investigated that the antioxidative effect of freeze-dried cranberry powder against protein and lipid oxidation and ameliorative effect of serum lipid profile in rat fed atherogenic diet. Six weeks old male Sprague-Dawley rats were divided into the following four groups: normal diet group with 5% corn oil (control), atherogenic diet group with 5% corn oil, 10% lard, 1% cholesterol, and 0.5% sodium cholate (HFC), atherogenic plus 2% cranberry powder diet group (HFC + C2), and atherogenic plus 5% cranberry powder diet group (HFC + C5), and respective diet and water were fed daily for 6 weeks. After the experimental period, the serum lipid profile, such as total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride, ferric reducing ability of plasma (FRAP), plasma phenolics content, superoxide dismutase (SOD) activity, serum protein carbonyl and thiobarbituric acid reactive substances (TBARS) levels were examined. Total phenolic compound and total flavonoid levels in freeze-dried cranberry powder were 9.94 mg/g and 8.12 mg/g, respectively. Serum total cholesterol and LDL-cholesterol levels were not significantly different for cranberry powder treatment, but serum HDL-cholesterol level was significantly increased in HFC + C5 group compared with HFC group. Plasma FRAP value tended to be increased by cranberry powder treatment though there was no significant difference. Plasma total phenol concentrations and SOD activities were not significantly different among all groups. Serum protein carbonyl and TBARS levels were significantly decreased in HFC + C5 group compared with HFC group. Overall results suggested that freeze-dried cranberry powder might have the serum lipid improving effect, as well as antioxidative effect demonstrated by its protective effect against protein and lipid oxidation.

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Cranberry Juice Increases Antioxidant Status Without Affecting Cholesterol Homeostasis in Orchidectomized Rats

Cited by 27 publications

References 41 publications

Cranberry anthocyanin extract prolongs lifespan of fruit flies

Cranberry anthocyanin extract prolongs lifespan of fruit flies

Effects of cranberry powder on biomarkers of oxidative stress and glucose control indb/dbmice

Effects of cranberry powder on serum lipid profiles and biomarkers of oxidative stress in rats fed an atherogenic diet

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