Cranial and Intracranial Lesions in Neurofibromatosis

Davidson, Kendrick C.

doi:10.2214/ajr.98.3.550

Cited by 47 publications

(18 citation statements)

References 4 publications

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“…Hunt and Pugh 18 advanced this theory to explain cranial lesions that had no adjacent tumor or mass and, therefore, could not be the result of pressure-induced osteolysis. This concept is supported by the following clinical observations: 1) there are several descriptions of patients in whom the surgical specimen 9,17 or radiographic analysis 21 failed to detect any contiguous tumor; 2) some cases of sphenoorbital dysplasia are clearly present at birth; 25 and 3) the distribution of cranial lesions is remarkably consistent. Orbital lesions of the posterior superior orbit occur in approximately 11% of patients with NF1, 6 while involvement in other areas of the cranial base is extraordinarily rare.…”

Section: Discussionmentioning

confidence: 83%

“…6 Calvarial involvement in patients with NF1 is uncommon, however there have been several reports of defects in the oc-cipital and parietal cranium. 9,17,18,21,33 In most of these cases, it was unclear whether the bone gap was congenital or acquired. We present the cases of two patients with NF1 who experienced progressive, massive calvarial osteolysis and were treated with different operative strategies.…”

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confidence: 99%

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Calvarial defects associated with neurofibromatosis Type 1

Mislow¹,

Proctor²,

McNeely³

et al. 2007

Journal of Neurosurgery: Pediatrics

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Calvarial osteolysis is a relatively rare finding in patients with neurofibromatosis. The authors describe two patients with neurofibromatosis Type 1 (NF1) and extensive cranial defects associated with underlying dural ectasia. Cranioplasties were performed in both patients with mixed results. One patient underwent cranioplasty using titanium mesh and methylmethacrylate. The other patient underwent an extensive cranioplasty with autogenous iliac crest grafting, and after initial healing has since had further bone resorption. In conclusion, the results of cranial reconstruction in patients with NF1 and dural ectasia are unpredictable because of the tendency for further bone resorption; techniques that protect the graft material from cerebrospinal fluid pulsations via a rigid mesh should be considered.

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Section: Discussionmentioning

confidence: 83%

mentioning

confidence: 99%

Calvarial defects associated with neurofibromatosis Type 1

Mislow¹,

Proctor²,

McNeely³

et al. 2007

Journal of Neurosurgery: Pediatrics

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“…Overgrowth of the soft tissues, in the form of plexiform lesions, produces mild to severe facial asymmetry but, surprisingly, the underlying bones show hypoplasia in most cases (Moore, 1941;James and Treggidon, 1975). Unilateral hypertrophy of facial bones in neurofibromatosis is extremely rare (Meszaros et a ] by Davidson (1966). Most of -the mandibular changes are best evaluated in the 20" occipitomental projection (Gupta et al, 1979).…”

Section: Discussionmentioning

confidence: 99%

Craniofacial Neurofibromatosis: A Roentgen Profile

Gupta

Kaur

1984

Australasian Radiology

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Neurofibromatosis is an hereditary, hamartomatous disorder, probably of neural crest origin, involving not only the neuroectoderm and mesoderm but also the endoderm and has the potential to appear in any organ system of the body. Osseous craniofacial abnormalities are uncommon compared with those of the axial and peripheral skeleton. The former include calvarial defects, changes in the mandible, zygomatic arch, orbit, tympanic bone, mastoid and sella turcica. The present communication records clinical and roentgen observation in the skull and facial bones in twenty cases of neurofibromatosis. MATERIAL AND METHOD Twenty cases of neurofibromatosis with involvement of the head and face region form the study material for this presentation. They were selected I:IGURE 1. -Lateral roentgenogram of the skull showing a well corticated defect in the lambdoid suture. A plexiform neuromatous lesion is superimposed on the parietotemporal region.

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“…On serial scans they will show a type 11, group I11 nature, like glioblastoma multiforme and metastasis. These tumors may be bilateral in neurofibromatosis (Davidson, 1966).…”

Section: Sarcomamentioning

confidence: 99%

The use of the brain scan in the diagnosis of intracranial neoplasia

Handmaker

Schall

1971

Journal of Surgical Oncology

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The brain scan has become a safe, efficient, and accurate method of screening patients who are suspected of having intracranial abnormalities. Tumor detection and localization are now possible in approximately 90% of patients seen, comparing favorably with results of angiography and pneumoencephalography. Improvements in radionuclides and detection equipment have made possible refinements of techniques to allow study of cerebral vasculature a t the time of nuclide injection for the routine static studies. Certain tumors have been found to have specific characteristics on the dynamic and static brain scans and can be predicted with some certainty in many instances. Normal scan anatomy and the various histologic tumor types and their patterns are described.

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Cranial and Intracranial Lesions in Neurofibromatosis

Cited by 47 publications

References 4 publications

Calvarial defects associated with neurofibromatosis Type 1

Calvarial defects associated with neurofibromatosis Type 1

Craniofacial Neurofibromatosis: A Roentgen Profile

The use of the brain scan in the diagnosis of intracranial neoplasia

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