Craniocervical Paraganglioma With Numerous Pulmonary Metastases -Case Report-

Abstract

A 28-year-old man presented with a rare craniocervical paraganglioma with multiple pulmonary metastases manifesting as hearing disturbance, hoarseness, and dysphagia in February 2003. Magnetic resonance imaging depicted a large jugular foramen tumor extending to the deep cervical region. Chest computed tomography revealed numerous small pulmonary nodules. The jugular tumor was totally resected immediately after preoperative embolization. Histological examination revealed paraganglioma. Localized irradiation (54 Gy) and two courses of combination chemotherapy consisting of paclitaxel (80 mg/m 2 ) and gemcitabine (1000 mg/m 2 ) were given. The patient remained well during follow up for 48 months and the number of pulmonary metastases did not increase. Local control of primary craniocervical paraganglioma by palliative surgical resection may be effective for control of metastatic lesions.

A SDHB malignant paraganglioma with dramatic response to temozolomide–capecitabine

“…The most used regimen combines cyclophosphamide, vincristine, and dacarbazine (CVD) and can provide tumor regression up to 50% (14). Other regimens have been tested, including gemcitabine alone or with docetaxel (15,16) or paclitaxel (17) and etoposide-cisplatin (18); however, treatment experience with all these regimens is limited and toxicities are severe, whereas quality of life is an important objective in patients whose survival may be long. Sunitinib appears to be a promising treatment in this malignancy based on a few case reports (19,20).…”

Serendipitous Detection of Cervical Nodal Metastasis in Glomus Jugulare

“…Chemotherapy has been reported to be unsuccessful. 13 Secreting paragangliomas need α-and β-adrenergic blockade prior to surgery. 3 Radiopharmaceutical treatment such as I-mIBG (I-metaiodobenzylguanidine) either alone or in combination with chemotherapy has been tried in a few cases.…”