Craniofacial bone tissue engineering

Petrovič, Vladimír; Zivkovic, Petar; Petrovic, D Nenad; Stefanović, Vladisav

doi:10.1016/j.oooo.2012.02.030

Cited by 74 publications

(43 citation statements)

References 76 publications

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“…Vertical ridge augmentation of atrophic mandible (posterior region) with customized, computer-aided design/computer-aided manufacturing (CAD/CAM) porous hydroxyapatite scaffolds has been tried [294]. However, HA has limited in vivo resorption and remodeling capacity, and are therefore unsuitable as onlay bone graft substitutes for vertical bone augmentation [19,295]. …”

Section: Natural Transplants and Synthetic Bone Replacement Graft mentioning

confidence: 99%

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Sima²,

2015

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Alveolar bone augmentation in vertical dimension remains the holy grail of periodontal tissue engineering. Successful dental implant placement for restoration of edentulous sites depends on the quality and quantity of alveolar bone available in all spatial dimensions. There are several surgical techniques used alone or in combination with natural or synthetic graft materials to achieve vertical alveolar bone augmentation. While continuously improving surgical techniques combined with the use of auto- or allografts provide the most predictable clinical outcomes, their success often depends on the status of recipient tissues. The morbidity associated with donor sites for auto-grafts makes these techniques less appealing to both patients and clinicians. New developments in material sciences offer a range of synthetic replacements for natural grafts to address the shortcoming of a second surgical site and relatively high resorption rates. This narrative review focuses on existing techniques, natural tissues and synthetic biomaterials commonly used to achieve vertical bone height gain in order to successfully restore edentulous ridges with implant-supported prostheses.

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Section: Natural Transplants and Synthetic Bone Replacement Graft mentioning

confidence: 99%

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Sima²,

2015

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“…Among the mineral materials, hydroxyapatite (HAp) is most commonly used because of its excellent biocompatibility, cell attachment capacity, and osteoconductivity, and it is commercially available in the form of porous implants and granular particles with pores [36, 39, 40, 160, 171]. It has been reported that bone marrow stem cells (BMSCs) show proliferation and differentiation into osteoblasts on porous HAp scaffolds in osteogenic medium, and the constructs of HAp and BMSCs form bone in vivo [171, 172].…”

Section: Scaffolds For Cellular Bone Tissue Engineering (Bone Tissmentioning

confidence: 99%

“…Among them, electrospinning has emerged for fabricating bone-mimetic nanofiber scaffolds. Electro spinning makes it possible to obtain microfibers and nanofibers from polymeric solutions or melts and to fabricate bone-mimetic nanofiber scaffolds [35, 40, 229]. Nanofibers have a large surface area-to-volume ratio and make fabrication of high porous scaffolds possible.…”

Section: Scaffolds For Cellular Bone Tissue Engineering (Bone Tissmentioning

confidence: 99%

“…Nanofibers have a large surface area-to-volume ratio and make fabrication of high porous scaffolds possible. These features are favorable for delivery of protein coating or signaling molecules, cell attachment, cell ingrowth, nutrient diffusion, and angiogenesis in the scaffold during the process of bone regeneration [40]. Electrospinning polymeric scaffolds are made with PLA, PGA, PCL, silk fibroin, calcium phosphates, and bioglass, and glass ceramics [40, 230].…”

Section: Scaffolds For Cellular Bone Tissue Engineering (Bone Tissmentioning

confidence: 99%

“…These features are favorable for delivery of protein coating or signaling molecules, cell attachment, cell ingrowth, nutrient diffusion, and angiogenesis in the scaffold during the process of bone regeneration [40]. Electrospinning polymeric scaffolds are made with PLA, PGA, PCL, silk fibroin, calcium phosphates, and bioglass, and glass ceramics [40, 230]. In both in vitro and in vivo studies, it is demonstrated that osteoprogenitor cells differentiate, proliferate, and adhere in synthetic-nanofibrous matrices [230, 231].…”

Section: Scaffolds For Cellular Bone Tissue Engineering (Bone Tissmentioning

confidence: 99%

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Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications

Kinoshita

Maeda

2013

The Scientific World Journal

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Autogenous bone grafting remains a gold standard for the reconstruction critical-sized bone defects in the craniomaxillofacial region. Nevertheless, this graft procedure has several disadvantages such as restricted availability, donor-site morbidity, and limitations in regard to fully restoring the complicated three-dimensional structures in the craniomaxillofacial bone. The ultimate goal of craniomaxillofacial bone reconstruction is the regeneration of the physiological bone that simultaneously fulfills both morphological and functional restorations. Developments of tissue engineering in the last two decades have brought such a goal closer to reality. In bone tissue engineering, the scaffolds are fundamental, elemental and mesenchymal stem cells/osteoprogenitor cells and bioactive factors. A variety of scaffolds have been developed and used as spacemakers, biodegradable bone substitutes for transplanting to the new bone, matrices of drug delivery system, or supporting structures enhancing adhesion, proliferation, and matrix production of seeded cells according to the circumstances of the bone defects. However, scaffolds to be clinically completely satisfied have not been developed yet. Development of more functional scaffolds is required to be applied widely to cranio-maxillofacial bone defects. This paper reviews recent trends of scaffolds for crania-maxillofacial bone tissue engineering, including our studies.

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Treatment Complications and Failures with Dental Implants

2018

Advances in Esthetic Implant Dentistry

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Craniofacial bone tissue engineering

Cited by 74 publications

References 76 publications

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications

Treatment Complications and Failures with Dental Implants

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