Craniofacial geometric morphometrics in the identification of patients with sickle cell anemia and sickle cell trait

Ferreira, Warli de Brito; Nunes, Lorena Andrade; Pithon, Matheus Melo; Maia, Lucianne Cople; Casotti, Cézar Augusto

doi:10.1016/j.htct.2019.10.003

Cited by 6 publications

(5 citation statements)

References 18 publications

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“…According to Nunes et al, (2018) (16) , it is possible identifying elderly individuals with diagnostic of diabetes and high blood pressureboth diseases or no illness at all -based on the morphology of the right side of the face by using geometric morphometrics. Ferreita et al, (2019) (13) found differences in the telemetry of patients with sickle cell anemia, non-affected sickle cell trait; this outcome shows that the geometric morphometrics is more effective than conventional anthropometry.…”

Section: Discussionmentioning

confidence: 97%

“…Geometric morphometrics (GM) is a tactic adopted for human health diagnostics, since it uses quantitative approach to assess changes and variations in the shape of individuals' morphologic structures -it allows describing the association between diseases and the human body (12,13) . It represents a method with the potential to assess the effects of environmental factors and diseases on organs and organisms (14) .…”

Section: Discussionmentioning

confidence: 99%

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Variation in mandible shape and size due to osteoporosis: Geometric morphometrics study

Ferreira,

Nunes,

Santana

et al. 2023

Int. j interdiscip. dent.

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Objective: Assessing whether it is possible screening women with osteoporosis through geometric morphometrics based on panoramic x-ray. Materials and Methods: Leukoderma women, after menopause, 40 years old (or older), with confirmed medical diagnosis of presence, or absence, of osteoporosis through bone densitometry examination. (N = 62). Measurements taken through panoramic X-ray based on geometric morphometrics. All x-rays were taken twice by the same researcher. Procrustes superimposition was assessed through Cartesian coordinates generated from anatomic landmark and semilandmarks. Regression Analysis, Multivariate Analysis of Variance (MANOVA), discriminant function and cross validation analysis, and Thin plate spliness in MorphoJ software were carried out. Subsequently, Fluctuating Asymmetry Analysis (FA) was conducted and ANOVA was performed to assess differences in centroid size. Results: Significant values were recorded for mandible shape (p<0.01) through MANOVA. Significant values (P<0.01) were also found through discriminant function analysis between groups of women with, and without, osteoporosis. Fluctuating asymmetry analysis showed significant differences in mandible shape and size between sides (p<0.01). Conclusions: Geometric morphometrics proved to be effective in screening and identifying elderly leukoderma women with, or without, osteoporosis based on panoramic x-rays. This is a promising technique to diagnose or identify patients with some health condition.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Variation in mandible shape and size due to osteoporosis: Geometric morphometrics study

Ferreira,

Nunes,

Santana

et al. 2023

Int. j interdiscip. dent.

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“…Ferreira WB (2020) also stated similar findings in Craniofacial geometric morphometrics in the identification of patients with sickle cell anemia and sickle cell trait. [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

Analyzing Effects of Sickle Cell Disease on Morphometric and Cranial Growth in Indian Population

Menka¹,

Anand²,

Jha

et al. 2021

Journal of Pharmacy and Bioallied Sciences

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Background: Sickle cell disease is the most pervasive autosomal recessive hereditary blood diseases and is characterized by the presence of sickle hemoglobin (HbS), which in turn gives rise to pathophysiological consequences. This HbS reduces the agility of erythrocytes plummeting their ability to pass through small vascular channels, which in turn results in increased blood viscosity and congestion of vascular beds, causing ischemia, local infarction, and hemolysis. Objectives: The current study was conducted to carry out the morphometric analysis in patients with sickle cell disease. Materials and Methods: This study was conducted on 75 subjects detected with sickle cell disease aged between 8 and 16.5 years. The study involved 38 males and 37 females. All the subjects were subjected to lateral cephalogram for the calculation of various angular and linear dimensions of the craniofacial structures. The linear measurements made were nasion-menton height, anterior nasal spine (ANS)-menton height, and nasion-ANS height, whereas the angular measurements made were Frankfurt mandibular plane angle, Frankfort mandibular incisor angle, and incisor mandibular plane angle. Results: Major chunk of the subjects had retruded mandible and vertical growth pattern. Few subjects exhibited with maxillary protrusion. Conclusion: It is concluded that early diagnosis and management of dental malocclusion in patients with sickle cell disease plays a pivotal role in an attempt to endow with a better quality of life to these individuals.

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“…Alguns desses pontos de referência foram escolhidos de modo a corresponder aos comumente já utilizados em sistemas cefalométricos tradicionais na análise de radiografias cefalométricas laterais, familiares à maioria dos cirurgiões-dentistas, principalmente ortodontistas, para determinação de maloclusão (Wellens, Kuijpers-Jagtman & Halazonetis, 2013). Além disso, alguns desses também já foram utilizados em outros estudos (Woon et al, 2019;Ferreira, Nunes, Pithon, Maia & Casotti, 2020;Pereira, Silva, Assis, Casotti & Nunes, 2021). A Tabela 1 descreve os marcos e os semimarcos anatômicos utilizados.…”

Section: Materiais E Métodosunclassified

Variações da forma e do tamanho craniofacial permitem identificar maloclusões dentárias?

Silva,

Nunes,

Andrade

et al. 2024

Rev. Uningá

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A partir da classificação de Angle, identificar e comparar alterações na forma e no tamanho da região craniofacial em telerradiografias laterais de face de indivíduos portadores de maloclusões dentárias. Trata-se de um estudo analítico transversal, realizado por meio da análise morfométrica de telerradiografias de indivíduos adultos portadores de maloclusões Classes I, II e III. Com o auxílio de pontos craniométricos e cefalométricos convencionais, marcos e semimarcos anatômicos foram inseridos. Para a verificação da variação da forma, realizou-se a MANOVA, análise de variável canônica, distância de Mahalanobis e Procrustes, função discriminante e validação cruzada. Também foi realizada a one-way ANOVA para o tamanho, com base no tamanho do centroide. Nas telerradiografias, foram encontradas diferenças significativas (p<0,05) entre as formas craniofaciais dos três grupos, a partir da MANOVA. A partir das grades de deformação, foi possível observar variações nas regiões mentoniana e anterior de maxila. A variação na forma das estruturas foi mais acentuada em telerradiografias do grupo com Classe III. As medidas das distâncias de Mahalanobis e de Procrustes foram maiores nas telerradiografias com maloclusões Classes II e III, corroborando com os resultados encontrados pela validação cruzada. Diferenças de tamanho (p<0,05) foram encontradas, a partir da one-way ANOVA e do teste de Tukey, ao comparar indivíduos Classe I com os demais grupos. A morfometria geométrica permitiu identificar variações da forma e do tamanho das estruturas craniofaciais. Essa técnica, quando aplicada às telerradiografias laterais, mostrou-se um método auxiliar promissor para caracterizar as maloclusões dentárias, segundo a classificação de Angle.

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Craniofacial geometric morphometrics in the identification of patients with sickle cell anemia and sickle cell trait

Cited by 6 publications

References 18 publications

Variation in mandible shape and size due to osteoporosis: Geometric morphometrics study

Variation in mandible shape and size due to osteoporosis: Geometric morphometrics study

Analyzing Effects of Sickle Cell Disease on Morphometric and Cranial Growth in Indian Population

Variações da forma e do tamanho craniofacial permitem identificar maloclusões dentárias?

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