Craniofacial Implant Surgery

Sinn, Douglas P.; Bedrossian, Edmond; Vest, Allison

doi:10.1016/j.coms.2011.01.005

Cited by 19 publications

(6 citation statements)

References 27 publications

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“…The change in the structure of the α3 chain occurs by cleavage between the LG domains from LG1 to LG5 [20]. It is known that cleavage between LG3 and LG4 is one of the most important events Strong osseointegration is crucial for successful dental implant therapy [3] [4].…”

Section: Discussionmentioning

confidence: 99%

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A Pilot Study of Antibody Drug Therapy to Regulate Cell Adhesion in Dental Implants

Kawai¹,

Ohura²

2017

OJST

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Dental implant therapy is a highly effective treatment for recovering occlusion after tooth loss. An important factor in the success of dental implants is establishing strong osseointegration. If more epithelial cells migrate to the implantbone interface than mesenchymal stem cells, effective osseointegration may fail. Therefore, controlling epithelial cell adhesion and motility would be an effective strategy to increase the success rate of osseointegration. Laminin-332 is a major component of the basement membrane and is composed of three chains (α3, β3 and γ2). It is well-known that laminin-332 regulates cellular functions such as adhesion, proliferation, apoptosis and differentiation. These biological functions depend on changes in the structural arrangement of laminin-332 by proteolytic cleavage. It is well-known that cleavage of the α3 chain between its LG domains gives laminin-332 its biological function. In this study, we focused on LG domain cleavage and developed antibodies that target the LG domain cleavage site. We attempted to change the biological function of laminin-332 to control cell adhesion for the purpose of regulating dental implant therapy.

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Section: Discussionmentioning

confidence: 99%

“…The success of dental implants is related to effective osseointegration [3] [4]. Strong osseointegration may be lost when epithelial cells invade the target sites earlier than mesenchymal stem cells [5] [6].…”

Section: Introductionmentioning

confidence: 99%

A Pilot Study of Antibody Drug Therapy to Regulate Cell Adhesion in Dental Implants

Kawai¹,

Ohura²

2017

OJST

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“…Being removable, they also allow for cleaning and regular surveillance of the tumor resection site. 4,5 Extraoral implants have been used successfully for many years for prosthesis fixation in the auricular, orbital, and nasal regions. 4 In patients with extensive midfacial defects, combining craniofacial prostheses with intraoral dentures allows for near complete restoration of both cosmetic and functional requirements.…”

Section: Introductionmentioning

confidence: 99%

Immediate Implant Placement and Provisionalization Following Tumor‐Resective Surgery in the Midfacial Region: A Case Series

Fernandes

Heever

Sykes

2017

Journal of Prosthodontics

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Surgical and prosthodontic restoration of the midfacial region following tumor resection has always posed a considerable challenge, as this area serves crucial functional and esthetic roles. Being diagnosed and subsequently treated for facial tumors can have an immense psychosocial impact on a patient, as the resulting defects are often disfiguring, and lead to an inability to masticate, swallow, and speak clearly. Provision of an immediate facial and dental prosthesis at the time of surgery can limit these side effects and help reduce mental duress on these patients and their families, as well as aid in the process of rehabilitation. Rapid prototyping (RP) and 3D printing, as this paper shows, assists presurgical planning of the tumor resection, as well as the manufacture of maxillofacial and dental prostheses. Often these defects are extensive, so prosthesis retention is aided by zygomatic implants placed at the time of surgical resection. When placed at this time, and prior to radiation therapy, these craniofacial implants have improved survival rates. Thus, this treatment modality can improve postoperative recovery considerably, while at the same time allowing for cleaning and monitoring of the resected site for tumor recurrence.

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“…[1][2][3][4] In the recent past, the possibilities of additive manufacturing (AM) like complexity for free or material efficiency has led to printed implants as well. implants are an important tool in modern medicine to reconstruct bone structures regarding the human skull.…”

Section: Introductionmentioning

confidence: 99%

“…Nowadays, the production of such implants is normally done by milling based on patient-specific computer tomography data. [1][2][3][4] In the recent past, the possibilities of additive manufacturing (AM) like complexity for free or material efficiency has led to printed implants as well. Hereby, selective laser sintering (SLS) is used as standard production technology.…”

Section: Introductionmentioning

confidence: 99%

Cranial Polypropylene Implants by Fused Filament Fabrication

Katschnig

Arbeiter²,

Haar

et al. 2016

Adv Eng Mater

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This study evaluates the feasibility and suitability of polypropylene (PP) implants produced by Fused Filament Fabrication (FFF) for the substitution of damaged cranial bone material from the polymerengineering point of view. The establishing of imaging methods, suitable printing material preparations, best printing practice regarding PP, and a first testing approach of the mechanical implant performance are addressed. Results indicate that PP implants are accurately printable and seem to be mechanical usable for cranial bone substitution. Further investigations concerning impact behavior and medical applicability will be conducted.

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Craniofacial Implant Surgery

Cited by 19 publications

References 27 publications

A Pilot Study of Antibody Drug Therapy to Regulate Cell Adhesion in Dental Implants

A Pilot Study of Antibody Drug Therapy to Regulate Cell Adhesion in Dental Implants

Immediate Implant Placement and Provisionalization Following Tumor‐Resective Surgery in the Midfacial Region: A Case Series

Cranial Polypropylene Implants by Fused Filament Fabrication

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