The study of evolutionary changes in human teeth is relevant from the point of view of identifying the geographical, ethnic, constitutional and sexual variability of the dentoalveolar system as a whole. The results of such studies can be used to predict the prevalence of anomalies and deformities of teeth, taking into account their epochal variability. The purpose of the study was to study the variability of the values of odontometric parameters of the teeth of the female population of the city of Krasnoyarsk in the 17th–21st centuries. The studied odontological materials (55 samples) were obtained during archaeological excavations of the necropolises of the city of Krasnoyarsk: 32 samples from the materials of the Pokrovsky necropolis of the 17th–18th centuries; 23 - from the materials of the Vsekhsvyatsky Necropolis of 18th–19th centuries. In addition, the data of studies of modern women (188 people) aged 21-35 years old, who were examined at the Department of Therapeutic Dentistry of the Professor Voyno-Yasenetsky Krasnoyarsk State Medical University. Within the framework of the study, the vestibulo-oral and mesio-distal diameters of the crowns of the teeth of the upper and lower jaws were studied, taking into account their group affiliation, anatomical shape, according to the method of Russian anthropologist Aleksandr Zubov. Statistical analysis included non-parametric methods of descriptive statistics and methods for comparing two or more independent samples. Analysis of the variability of the vestibulo-oral diameter of the crowns in the functional group of the molars of the upper and lower jaws showed a stable process of reduction. The mesio-distal diameter of the incisor crowns differed statistically significantly only for the teeth of the lower jaw. A statistically significant decrease in the values of the median of the vestibulo-oral crown diameter was found in all key teeth of this group. The greatest reduction changes were registered in the first molars of the upper jaw. The first lower molars of representatives of different centuries did not have statistically significant differences in the size of the mesio-distal size of the crown of these teeth, as well as premolars. A comparative analysis of the obtained odontometric characteristics of the teeth showed a general trend towards a decrease in the size of the teeth of the female population of the Krasnoyarsk City, taking into account the time vector, which is a confirmation of the epochal reduction of the dentition.