Craniopharyngioma and epidermoid tumour in same child: a rare association

Abstract

SUMMARYSimultaneous occurrence of histologically different primary brain tumours is rare, and its preoperative diagnosis is still challenging. The explanations for the simultaneous occurrence of different primary intracranial tumours in the absence of phacomatoses or prior radiation exposure are at present hypothetical, and these tumours could be simply coincidental. Herein, we report a case of a boy presenting with features of raised intracranial pressure and right-sided sensorineural hearing loss. Brain MRI revealed two different neoplastic pathologies at different sites: an intrasellar and suprasellar craniopharyngioma and a right cerebellopontine angle epidermoid. To the best of our knowledge, this is the first report in literature of a craniopharyngioma coexisting with an epidermoid, in the same individual. BACKGROUND

Central Neurocytoma and Epidermoid Tumor Occurring as Collision Tumors: A Rare Association

“…The synchronous occurrence of multiple primary brain tumors of distinct histopathology is rare with the reported incidence of 0.3% [3]. Meningiomas are the most frequently reported to co-exist with another tumor of different cell type and the majority does not collide [3,4].…”

“…The synchronous occurrence of multiple primary brain tumors of distinct histopathology is rare with the reported incidence of 0.3% [3]. Meningiomas are the most frequently reported to co-exist with another tumor of different cell type and the majority does not collide [3,4]. Even more rare are collision brain tumors an ill-defined description where histologically discrete lesions are in such close proximity with each other that no discernible boundary exists between them on conventional imaging.…”

“…lision partner and is often associated with vestibular Schwannomas [2,3,[5][6][7][8][9]. Only seven epidermoid tumor collision cases have been described previously and to our knowledge the concomitant occurrence with central neurocytoma has never been reported.…”

“…Multiple primary brain tumors of entirely different cell origins are known to be associated with phakomatoses or previous irradiation [3,5]. In the absence of these risk…”

Coexistence of Craniopharyngioma and Cranial Fibrous Dysplasia: A Clinicopathological Study of 5 Cases and Literature Review

“…The de nite pathogenesis of this coexistence remains unknown, except familial or hereditary diseases such as neuro bromatosis type 2 or multiple endocrine neoplasia 1. Several hypotheses have been advocated to explain this phenomenon including purely coincidence, surgical trauma, radiation and/or chemical exposure, and genetic predisposition, but all in debating [10][11][12].…”