Craniopharyngiomas in Childhood: Analysis of 42 Cases

Lapras, C; Patet, J. D.; Mottolèse, C.; Gharbi, S.; Lapras, C

doi:10.1159/000413693

Cited by 31 publications

(7 citation statements)

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“…The intensity of the voracious appetite presum ably leads to the extreme food-seeking behavior. Rage and aggressivity are also described [5,[20][21][22], In our patients, these symptoms were most often provoked when food was denied them.…”

Section: Discussionsupporting

confidence: 55%

“…Although obesity is sometimes a clinical manifesta tion of craniopharyngioma, it is a well recognized com plication of surgical treatment of this tumor [3][4][5]. The prevalence varies from 6% [6] to 91 % [7], Hyperphagia is commonly reported [4,5,8,9] but the extreme nature that this symptom may assume and the adverse effects on social adjustment that may derive from the associated behavioral pathology have received little or no attention in the English literature.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence varies from 6% [6] to 91 % [7], Hyperphagia is commonly reported [4,5,8,9] but the extreme nature that this symptom may assume and the adverse effects on social adjustment that may derive from the associated behavioral pathology have received little or no attention in the English literature. All 3 of our patients showed abnormal food-seeking behavior including the stealing of food and stealing money for food.…”

Section: Discussionmentioning

confidence: 99%

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Abnormal Food-Seeking Behavior after Surgery for Craniopharyngioma

Skórzewska¹,

Lal²,

Waserman³

et al. 1989

Neuropsychobiology

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Three patients are described in whom surgical removal of a craniopharyngioma was followed by extreme hyperphagia resulting in obesity and abnormal food-seeking behavior, including foraging for food, stealing food or stealing money for food. These behaviors resemble those seen in the Prader-Willi syndrome but contrast with those noted in bulimia. This deviant behavior was a major factor in the poor outcome of surgery. Attempts at rehabilitation were unsuccessful.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Abnormal Food-Seeking Behavior after Surgery for Craniopharyngioma

Skórzewska¹,

Lal²,

Waserman³

et al. 1989

Neuropsychobiology

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“…In 50% of cases, the stalk is not invaded by the tumor, and it is possible, by close dissection, to preserve it anatomically. This does not translate into intact endocrinological functions postoperatively in every case but we think, like Honegger, et al, 42 and Lapras, et al, 52 that it is worth pre-serving the pituitary stalk when possible. A partial endocrinological deficit allows better quality of life than complete hypopituitarism, and some patients experience even complete preservation of all hormone functions.…”

Section: Surgical Mortalitymentioning

confidence: 83%

Craniopharyngioma in adults and children: a study of 122 surgical cases

Effenterre

Boch²

2002

Journal of Neurosurgery

452

353

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“…[27] Gross total resections may give rise to a cure, but major series reported have a success rate ranging between 30% and 97%. [28353868757879] Recurrence rates vary between 5% and 10% in some series to as high as 50% following so called “gross total” resections. The success rates of gross total resections reported in a large recently reported single center series is 95.6% for tumors with a diameter of less than 6 cm and 58.8% for those with diameters greater than 6 cm.…”

Section: Discussionmentioning

confidence: 99%

Minimally invasive management of adult craniopharyngiomas: An analysis of our series and review of literature

Rahmathulla

Barnett

2013

Surg Neurol Int

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Background:Craniopharyngiomas (CPs) are slow growing tumors with an incidence of between 1.2% and 4.6%, having a bimodal age distribution typically peaking in childhood and in adults between 45 and 60 years. Recurrences occur even after documented gross total resections necessitating a combination of therapeutic strategies. Obtaining a cure of this tumor in adults without producing major side effects continues to remain elusive.Methods:We describe our results in 11 patients with CP treated in a minimally invasive fashion using a combination of techniques like burr hole aspiration, Ommaya reservoir placement, ventriculo-peritoneal (VP) shunting and focal radiation (Gamma Knife stereotactic radiosurgery/Intensity modulated radiotherapy [GKRS/IMRT]).Results:Visual function remained intact in all patients; endocrine status remained stable with two patients developing new postoperative diabetes insipidus. There was no periprocedural morbidity or mortality, with hospital stays for any in-patient procedure being 48 hours or less.Conclusions:Minimally invasive techniques such as cyst aspiration, insertion of a catheter with Ommaya reservoir, when combined with stereotactic radiosurgery/IMRT is an effective and safe option for management and long-term control of adult CPs. We believe the Ommaya catheter by itself could act as a stent, creating a tract allowing gradual drainage of cyst fluid and stabilization without necessitating any further interventions in selected cases.

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Craniopharyngiomas in Childhood: Analysis of 42 Cases

Cited by 31 publications

References 0 publications

Abnormal Food-Seeking Behavior after Surgery for Craniopharyngioma

Abnormal Food-Seeking Behavior after Surgery for Craniopharyngioma

Craniopharyngioma in adults and children: a study of 122 surgical cases

Minimally invasive management of adult craniopharyngiomas: An analysis of our series and review of literature

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