Cratoxylum cochinchinense (Hypericaceae): a New Record for Sulawesi, Indonesia

Mustaqim, Wendy A.; Amboupe, Dewi

doi:10.56899/149.03.18

Cited by 2 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They are frequently seen in pairs on flowering shoots that are 5 -15 cm long and appear at the angles of leaves or branch terminals. The fruits are capsular and ellipsoid in shape [3]. A study by Nguyen et al [8] provides an indepth ethnobotany description of C. cochinchinense, matching an earlier report by Mahabusarakam et al [9].…”

Section: Introductionsupporting

confidence: 65%

“…Cratoxylum cochinchinense (Lour.) Blume is a polyphenol-rich plant found in Southeast Asia, and it is categorized under the Hypericaceae family [1][2][3]. It is an evergreen, perennial tree that can grow up to 33 meters in height [2].…”

Section: Introductionmentioning

confidence: 99%

“…It is an evergreen, perennial tree that can grow up to 33 meters in height [2]. The tree is widely distributed in Indochina, China, Thailand, Sulawesi, Sumatra, Malaysia, Borneo and the Philippines [2,3]. The common name in English for C. cochinchinense is Yellow Cow Wood or Tree-Avens.…”

Section: Introductionmentioning

confidence: 99%

“…Its opposing, stalked leaves (Figure 2) with a curve have fleshy to papery leaf blades that are 3-13 by 1-4.4 cm, with minute gland-dots, curved lateral veins, which unite but do not form intramarginal veins, and are oval to oblong to lanceshaped [7]. The young twigs are flattened and the leaves are simple with lateral vein and elliptical or sometimes slightly obovate [3]. Its mature leaf blades are green on top and grey-green on the undersides, with a pronounced bloom.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A Review on the Cytotoxic and Antimicrobial Properties of Xanthones from Cratoxylum cochinchinense

Lee¹,

Mojulat²,

Thangaperagasam³

et al. 2023

J.Trop.Life.Science

View full text Add to dashboard Cite

Cratoxylum cochinchinenseis a perennial plant found in Southeast Asia, having di-verse terminologies in various Southeast Asian countries. It has been traditionally used as medicine, tea and food spice until today. Its phytochemical analysis reveals a rich array of bioactive compounds in different parts of the plant, specifically xan-thones, which are scientifically determined to be the most abundant secondary me-tabolites in C. cochinchinense. Xanthones do possess numerous beneficial properties and are actively researched to unlock its vast potential. It could be synthesized both biologically and synthetically, where the latter method is gaining much interest among researchers to improve its biological properties. Due to limited compiled re-sources on the biological benefits of xanthones from C. cochinchinense, this paper aims to review theircytotoxic properties specifically towards cancer cells, as well as their antimalarial and antibacterial effects in order to further support the medicinal use of this plan

show abstract

Section: Introductionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Review on the Cytotoxic and Antimicrobial Properties of Xanthones from Cratoxylum cochinchinense

Lee¹,

Mojulat²,

Thangaperagasam³

et al. 2023

J.Trop.Life.Science

View full text Add to dashboard Cite

show abstract

“…Cratoxylum cochinchinense belongs to the family of Hypericaceae and grows naturally in Southern Asian countries ( Mustaqim and Amboupe, 2020 ). The roots and bark are both used in traditional Chinese medicine for the treatment of fevers, burns, and abdominal complications ( Thu et al, 2017 ; Tan et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Investigation of bacterial neuraminidase inhibition of xanthones bearing geranyl and prenyl groups from Cratoxylum cochinchinense

Kim

Lee

et al. 2023

Front. Chem.

View full text Add to dashboard Cite

Introduction: The root of Cratoxylum cochinchinense has been widely used as Chinese folk medicine to cure fevers, burns, and abdominal complications because it contains various bioactive metabolites such as xanthones, triterpenes, and flavonoids. In this study, we estimated bacterial neuraminidase inhibition with a series of xanthones from C. cochinchinense. BNA has connected to various biological functions such as pathogenic bacteria infection inflammatory process after infection and biofilm formation.Methods: The identification of xanthones (1–6) bearing geranyl and prenyl groups was established by spectroscopic data using UV, IR, NMR, and HREIMS. BNA inhibitory modes of isolated xanthones were investigated by Double-reciprocal plots. Moreover, the competitive inhibitor was evaluated the additional kinetic modes determined by kinetic parameters (k3, k4, and Kiapp). The molecular docking (MD) and molecular dynamics simulations (MDS) studies also provided the critical information regarding the role of the geranyl and prenyl groups against BNA inhibition.Results: A series of xanthones (1–6) appended prenyl and geranyl groups on the A-ring were isolated, and compounds 1–3 were shown to be new xanthones. The analogues within this series were highly inhibited with excellent affinity against bacterial neuraminidase (BNA). A subtle change in the prenyl or geranyl motif affected the inhibitory potency and behavior significantly. For example, the inhibitory potency and binding affinity resulting from the geranyl group on C4: xanthone 1 (IC50 = 0.38 μM, KA = 2.4434 × 105 L·mol−1) were 100-fold different from those of xanthone 3 (IC50 = 35.8 μM, KA = 0.0002 × 105 L·mol−1). The most potent compound 1 was identified as a competitive inhibitor which interacted with BNA under reversible slow-binding inhibition: Kiapp = 0.1440 μM, k3 = 0.1410 μM−1s−1, and k4 = 0.0203 min−1. The inhibitory potencies (IC50) were doubly confirmed by the binding affinities (KA).Discussion: This study suggests the potential of xanthones derived from C. cochinchinense as promising candidates for developing novel BNA inhibitors. Further research and exploration of these xanthones may contribute to the development of effective treatments for bacterial infections and inflammatory processes associated with BNA activity.

show abstract

Cratoxylum cochinchinense (Hypericaceae): a New Record for Sulawesi, Indonesia

Cited by 2 publications

References 0 publications

A Review on the Cytotoxic and Antimicrobial Properties of Xanthones from Cratoxylum cochinchinense

A Review on the Cytotoxic and Antimicrobial Properties of Xanthones from Cratoxylum cochinchinense

Investigation of bacterial neuraminidase inhibition of xanthones bearing geranyl and prenyl groups from Cratoxylum cochinchinense

Contact Info

Product

Resources

About