CrCl<sub>2</sub>-catalyzed α-alkylation of carbonyl compounds <i>via</i> a borrowing hydrogen approach

Wei, Dongyue; Feng, Baojin; Chen, Qing; Yue, Wantong; Wang, Yilei; Peng, Zhihua

doi:10.1039/d3qo01862h

Org. Chem. Front.

2024

DOI: 10.1039/d3qo01862h

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CrCl₂-catalyzed α-alkylation of carbonyl compounds via a borrowing hydrogen approach

Dongyue Wei,

Baojin Feng,

Qing Chen

et al.

Abstract: A new and efficient catalytic system for sustainable α-alkylation of carbonyl compounds with alcohols which serve as alkylating agents via a borrowing hydrogen strategy was presented. The developed practical catalytic...

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Cited by 6 publications

References 56 publications

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A Chromium Catalytic System for the Synthesis of Aryl‐Substituted 1,3,5‐Triazines and Pyrimidines by Acceptorless Dehydrogenative Coupling

Feng,

Yue,

Wei

et al. 2024

Eur J Org Chem

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A novel and highly efficient methodology for the synthesis of 2,4,6‐triaryl‐1,3,5‐triazines and 2,4,6‐trisubstituted pyrimidines from amidines and alcohols has been established. Using the Earth‐abundant and air‐stable chromium salt catalyst and the phosphine‐free ligand, the developed Cr‐catalyzed acceptorless dehydrogenative coupling provides 1,3,5‐triazines and pyrimidines with high yields and good functional group tolerance. Moreover, the synthetic value of this operationally simple protocol was demonstrated by gram‐scale experiment and the synthesis of the linker to construct various supramolecular complexes.

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A Chromium Catalytic System for the Synthesis of Aryl‐Substituted 1,3,5‐Triazines and Pyrimidines by Acceptorless Dehydrogenative Coupling

Feng,

Yue,

Wei

et al. 2024

Eur J Org Chem

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Highly dispersed ruthenium capsulated in UiO-66-NH₂ for hydrogen-borrowing-mediated N-alkylation reactions

Li,

Ou,

Sang

et al. 2024

Catal. Sci. Technol.

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Chromium-catalyzed sustainable C–C and C–N bond formation: C-alkylation and Friedländer quinoline synthesis using alcohols

Atreya,

Jalwal,

Chakraborty

2025

Dalton Trans.

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CrCl₂-catalyzed α-alkylation of carbonyl compounds via a borrowing hydrogen approach

Abstract: A new and efficient catalytic system for sustainable α-alkylation of carbonyl compounds with alcohols which serve as alkylating agents via a borrowing hydrogen strategy was presented. The developed practical catalytic...

Cited by 6 publications

References 56 publications

A Chromium Catalytic System for the Synthesis of Aryl‐Substituted 1,3,5‐Triazines and Pyrimidines by Acceptorless Dehydrogenative Coupling

A Chromium Catalytic System for the Synthesis of Aryl‐Substituted 1,3,5‐Triazines and Pyrimidines by Acceptorless Dehydrogenative Coupling

Highly dispersed ruthenium capsulated in UiO-66-NH₂ for hydrogen-borrowing-mediated N-alkylation reactions

Chromium-catalyzed sustainable C–C and C–N bond formation: C-alkylation and Friedländer quinoline synthesis using alcohols

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CrCl2-catalyzed α-alkylation of carbonyl compounds via a borrowing hydrogen approach

Abstract: A new and efficient catalytic system for sustainable α-alkylation of carbonyl compounds with alcohols which serve as alkylating agents via a borrowing hydrogen strategy was presented. The developed practical catalytic...

Cited by 6 publications

References 56 publications

A Chromium Catalytic System for the Synthesis of Aryl‐Substituted 1,3,5‐Triazines and Pyrimidines by Acceptorless Dehydrogenative Coupling

A Chromium Catalytic System for the Synthesis of Aryl‐Substituted 1,3,5‐Triazines and Pyrimidines by Acceptorless Dehydrogenative Coupling

Highly dispersed ruthenium capsulated in UiO-66-NH2 for hydrogen-borrowing-mediated N-alkylation reactions

Chromium-catalyzed sustainable C–C and C–N bond formation: C-alkylation and Friedländer quinoline synthesis using alcohols

Contact Info

Product

Resources

About

CrCl₂-catalyzed α-alkylation of carbonyl compounds via a borrowing hydrogen approach

Highly dispersed ruthenium capsulated in UiO-66-NH₂ for hydrogen-borrowing-mediated N-alkylation reactions