Creatine attenuates seizure severity, anxiety and depressive-like behaviors in pentylenetetrazole kindled mice

Okwuofu, Emmanuel O.; Ogundepo, Gbenga Emmanuel; Akhigbemen, Abigail M.; Abiola, Akinpelu Lateef; Ozolua, Raymond I.; Igbe, Ighodaro; Chinazamoku, Ononiwu

doi:10.1007/s11011-021-00684-w

Cited by 9 publications

(4 citation statements)

References 67 publications

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“…The use of creatine has also been investigated in other clinical models where depression is often observed as a secondary consequence of disease, or it results from the treatment. For example, in a mouse model of epilepsy, dietary creatine treatment not only attenuated seizure severity, but it also reduced depressive-like behaviors [ 115 ]. Creatine has also been shown to have anti-depressant effects in amyloid β 1-40 treated mice, a model of Alzheimer’s disease related depression [ 116 ].…”

Section: Creatine and Mental Healthmentioning

confidence: 99%

Effects of Creatine Supplementation on Brain Function and Health

et al. 2022

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While the vast majority of research involving creatine supplementation has focused on skeletal muscle, there is a small body of accumulating research that has focused on creatine and the brain. Preliminary studies indicate that creatine supplementation (and guanidinoacetic acid; GAA) has the ability to increase brain creatine content in humans. Furthermore, creatine has shown some promise for attenuating symptoms of concussion, mild traumatic brain injury and depression but its effect on neurodegenerative diseases appears to be lacking. The purpose of this narrative review is to summarize the current body of research pertaining to creatine supplementation on total creatine and phophorylcreatine (PCr) content, explore GAA as an alternative or adjunct to creatine supplementation on brain creatine uptake, assess the impact of creatine on cognition with a focus on sleep deprivation, discuss the effects of creatine supplementation on a variety of neurological and mental health conditions, and outline recent advances on creatine supplementation as a neuroprotective supplement following traumatic brain injury or concussion.

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Section: Creatine and Mental Healthmentioning

confidence: 99%

Effects of Creatine Supplementation on Brain Function and Health

et al. 2022

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“…In this study, creatine supplementation (75, 150, or 300 mg/kg, orally for 15 days) significantly reduced seizure severity scores, anxiety, and depressionlike behaviors in mice from the 5 th day of treatment. In addition, creatine significantly increased catalase and glutathione activities and decreased lipid peroxidation when compared to vehicle treated PTZ-kindled mice suggesting antioxidant activity of this compound (Table 1; Okwuofu et al, 2021).…”

Section: Okwuofu Et Al (2021)mentioning

confidence: 91%

“…Recently, the ameliorative effects of creatine supplementation on seizure severity and behavioral changes were evaluated in PTZ-kindled mice as a model of chronic epilepsy ( Okwuofu et al, 2021 ). Kindling is a process of inducing progressive intensity of convulsive activity as a result of repetitive administration of chemical or electrical sub-convulsive stimuli ( Pavlova et al, 2004 ).…”

Section: Creatinementioning

confidence: 99%

Potential role of creatine as an anticonvulsant agent: evidence from preclinical studies

Alraddadi,

Khojah,

Alamri

et al. 2023

Front. Neurosci.

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Epilepsy is one of the most common neurological disorders affecting people of all ages representing a significant social and public health burden. Current therapeutic options for epilepsy are not effective in a significant proportion of patients suggesting a need for identifying novel targets for the development of more effective therapeutics. There is growing evidence from animal and human studies suggesting a role of impaired brain energy metabolism and mitochondrial dysfunction in the development of epilepsy. Candidate compounds with the potential to target brain energetics have promising future in the management of epilepsy and other related neurological disorders. Creatine is a naturally occurring organic compound that serves as an energy buffer and energy shuttle in tissues, such as brain and skeletal muscle, that exhibit dynamic energy requirements. In this review, applications of creatine supplements in neurological conditions in which mitochondrial dysfunction is a central component in its pathology will be discussed. Currently, limited evidence mainly from preclinical animal studies suggest anticonvulsant properties of creatine; however, the exact mechanism remain to be elucidated. Future work should involve larger clinical trials of creatine used as an add-on therapy, followed by large clinical trials of creatine as monotherapy.

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“…For instance, in a study using mice with epilepsy, a diet supplemented with creatine not only reduced the severity of seizures but also decreased depressive-like behaviors. 34 In another study, antidepressant effects in mice treated with amyloid β1-40, a model of depression related to Alzheimer's disease were demonstrated. 35 Chronic corticosterone treatment, which can lead to depression-like symptoms, has also been investigated.…”

Section: Creatine Supplementation and Brain Functionmentioning

confidence: 98%

Supplementation of creatine and its role in brain function

Abod,

Ilnicka,

Matyja

et al. 2023

J Educ Health Sport

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Introduction and aim. In recent years growing awareness of the society regarding healthy lifestyle leads to increased interest in regular physical activity and usage of dietary supplements. Creatine supplementation is often used among athletes to improve muscle mass, performance and recovery. The aim of this paper is to present the effects of creatine supplementation as well as its function in the body, forms and ways of intake, and potential benefits of its use. Material and methods. A review of the available literature was performed by searching the PubMed and GoogleScholar databases using the following keywords: creatine, creatine supplementation, sports nutrition, brain function Analysis of literature. Creatine is one of the most popular supplements recommended for athletes. It catalyzes transfer of phosphate groups into high energy compounds contributing in energy transportation and cellular energy buffering for cells and tissues with high energy demands. Its supplementation improves exercise performance, increases muscle mass and enhances recovery after training. In addition, there are indications that creatine shows promise in reducing symptoms associated with concussion, mild traumatic brain injury, and depression. Conclusion. Creatine supplementation is used in sport mainly to improve exercise performance and muscle gain, however, it also plays an important role in brain function. In future it may be used in reducing symptoms associated with concussion, mild traumatic brain injury and depression.

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Creatine attenuates seizure severity, anxiety and depressive-like behaviors in pentylenetetrazole kindled mice

Cited by 9 publications

References 67 publications

Effects of Creatine Supplementation on Brain Function and Health

Effects of Creatine Supplementation on Brain Function and Health

Potential role of creatine as an anticonvulsant agent: evidence from preclinical studies

Supplementation of creatine and its role in brain function

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