Creatine, Creatine Kinase, and Aging

Sumien, Nathalie; Shetty, Ritu A.; Gonzales, Eric B.

doi:10.1007/978-981-13-2835-0_6

Cited by 41 publications

(34 citation statements)

References 128 publications

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“…High serum LDH activity is a marker of cell damage [ 28 , 29 ] while serum CK is an indicator of muscle degradation. Because CK levels are highly sensitive to muscle injury, this level can be used as a tool to diagnose muscle damage [ 30 , 31 ]. Serum ALT activity is a reliable marker of liver disease and general health.…”

Section: Discussionmentioning

confidence: 99%

Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia Prevention

et al. 2021

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Oxidative stress and later-induced chronic inflammation have been reported to play an important role on the progression of sarcopenia. Current treatments for sarcopenia are mainly administered to patients whom sarcopenia already developed. However, there has been no promising results shown in therapy. Therefore, the development of therapeutic and preventive strategies against sarcopenia would be necessary. Curcumin is a traditional medicine that possesses anti-inflammatory and antioxidative properties. In the present study, hydroxyapatite was subjected to hydrophobic surface modifications for curcumin loading (Cur-SHAP). It was, subsequently, utilized for delivery to the patient’s body via intramuscular injection in order to achieve constant release for more than 2 weeks, preventing the progression of the sarcopenia or even leading to recovery from the early stage of the illness. According to the results of WST-1, LIVE/DEAD, DCFDA, and gene expression assays, Cur-SHAP exhibited good biocompatibility and showed great antioxidant/anti-inflammatory effects through the endocytic pathway. The results of the animal studies showed that the muscle endurance, grip strength, and fat/lean mass ratio were all improved in Cur-SHAP-treated rats from LPS-induced sarcopenia. In summary, we successfully synthesized hydrophobic surface modification hydroxyapatite for curcumin loading (Cur-SHAP) and drug delivery via the IM route. The LPS-induced sarcopenia rats were able to recover from disease after the Cur-SHAP treatment.

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Section: Discussionmentioning

confidence: 99%

Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia Prevention

et al. 2021

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“…Creatine is a metabolite that is gained through food intake, and synthesized from arginine, methionine and glycine [42]. It is essential to healthy cell and tissue function and is utilized by the amino acid pathway [86]. Elevated levels of creatine in urine are likely due to the inability of injured muscle to take up and use the available metabolite [18,42,45,87].…”

Section: Creatinementioning

confidence: 99%

A Systematic Review of Metabolomic and Lipidomic Candidates for Biomarkers in Radiation Injury

2020

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A large-scale nuclear event has the ability to inflict mass casualties requiring point-of-care and laboratory-based diagnostic and prognostic biomarkers to inform victim triage and appropriate medical intervention. Extensive progress has been made to develop post-exposure point-of-care biodosimetry assays and to identify biomarkers that may be used in early phase testing to predict the course of the disease. Screening for biomarkers has recently extended to identify specific metabolomic and lipidomic responses to radiation using animal models. The objective of this review was to determine which metabolites or lipids most frequently experienced perturbations post-ionizing irradiation (IR) in preclinical studies using animal models of acute radiation sickness (ARS) and delayed effects of acute radiation exposure (DEARE). Upon review of approximately 65 manuscripts published in the peer-reviewed literature, the most frequently referenced metabolites showing clear changes in IR induced injury were found to be citrulline, citric acid, creatine, taurine, carnitine, xanthine, creatinine, hypoxanthine, uric acid, and threonine. Each metabolite was evaluated by specific study parameters to determine whether trends were in agreement across several studies. A select few show agreement across variable animal models, IR doses and timepoints, indicating that they may be ubiquitous and appropriate for use in diagnostic or prognostic biomarker panels.

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“…Still, the number of cases in which creatine levels are higher in the older groups is more than twice as high as the cases in which the metabolite shows higher levels in the younger age groups. Several studies have indicated that disturbances of the creatine, phosphocreatine, and creatine kinase system, are associated with ageing, suggesting that supplementation with creatine can reverse age-associated functional declines (Sumien et al 2018 ), however more studies are probably needed to conclude whether this is universal or varies for different populations.…”

Section: Resultsmentioning

confidence: 99%

MetaboAge DB: a repository of known ageing-related changes in the human metabolome

Mracica

Anghel²,

Ion

et al. 2020

Biogerontology

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Accumulating metabolomics data is starting to become extremely useful in understanding the ageing process, by providing a snapshot into the metabolic state of tissues and organs, at different ages. Molecular studies of such metabolic variations during “normal” ageing can hence guide lifestyle changes and/or medical interventions aimed at improving healthspan and perhaps even lifespan. In this work, we present MetaboAge, a freely accessible database which hosts ageing-related metabolite changes, occurring in healthy individuals. Data is automatically filtered and then manually curated from scientific articles reporting statistically significant associations of human metabolite variations or correlations with ageing. Up to date, MetaboAge contains 408 metabolites annotated with their biological and chemical information, and more than 1515 ageing-related variations, graphically represented on the website grouped by validation methods, sex and age-groups. The MetaboAge database aims to continually structure the expanding information from the field of metabolomics in relation to ageing, thus making it more accessible for further research in gerontology.

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Creatine, Creatine Kinase, and Aging

Cited by 41 publications

References 128 publications

Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia Prevention

Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia Prevention

A Systematic Review of Metabolomic and Lipidomic Candidates for Biomarkers in Radiation Injury

MetaboAge DB: a repository of known ageing-related changes in the human metabolome

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