Creatine–facilitated protection of stress caused by disrupted circadian rhythm

Burjanadze, George; Sylla, Mariam; Dachanidze, Natalia; Mikadze, M; Menabde, Ketevan; Koshoridze, Nana

doi:10.1080/09291016.2017.1333198

Cited by 2 publications

(2 citation statements)

References 51 publications

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“…Hence, the stimulating effect of creatine on NMDA receptors must be mediated by cellular Ca 2+ and Na + channels and subsequent calcineurin pathway activation (5,6,19,20). These findings demonstrated that creatine supplementation improves learning and memory by a mechanism depending partially on the involvement of NMDA receptors and cellular ionic gradient maintenance (21,22).…”

Section: Glutamate Excitotoxicitymentioning

confidence: 82%

Creatine Activity as a Neuromodulator in the Central Nervous System

2023

ARI

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Creatine is a nutritional compound that potentially influences cognitive processing and neuroprotection. Recent evidence has demonstrated that similar to neurotransmitters, creatine is released in an excitotoxic and action potential-dependent manner and acts as a neuromodulator. Creatine deficiency syndromes are characterized by severe mental and developmental disorders. Studies have reported that brain creatine content could be enhanced with creatine supplementation. Nevertheless, there is still limited knowledge about the effects of creatine on the central nervous system. However, ample evidence has proved the neuroprotective effects of creatine on various mental aspects, such as cognition, memory skills, and spatial memory. The present review aimed to review available experimental data and clinical observations confirming creatine roles in the central transmission process. A systematic search in the literature was performed in PubMed, Scopus, Embase, Cochrane Library, Web of Science, and Google Scholar database using all available MeSH terms for Creatine, Phosphocreatine, Bioenergetics, Nervous system, Brain, Cognition, and Neuroprotection. Electronic database searches were combined and duplicates were removed. Here, first, creatine and its potential influence on cognitive health and performance were briefly reviewed. Next, the existing experimental and clinical evidence was specifically explored to understand how creatine could interact as a neurotransmitter in the nervous system. Studies have revealed that exogenous creatine supplementation decreases neuronal cell loss in experimental paradigms of neurological diseases. It was observed that creatine could interact with the N-methyl-D-aspartate receptor, Na+-K+-ATPase enzyme, GABAA receptor, serotonin 1A receptors, and presumably α1-adrenoceptor and play critical roles in the central transmission process which implies that creatine can be considered a neuromodulator.

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Section: Glutamate Excitotoxicitymentioning

confidence: 82%

Creatine Activity as a Neuromodulator in the Central Nervous System

2023

ARI

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“…Specifically, Koga et al (2005) directly assessed the effects of creatine supplementation on stress-induced impairments and reported that the direct administration of creatine into the brain significantly reduced stress responses and plasma corticosterone concentrations. Burjanadze et al (2018) demonstrated that daily i.p. administration of creatine, similar to creatine feeding, improved behavioral changes caused by stressful conditions.…”

Section: Discussionmentioning

confidence: 99%

Creatine supplementation protects spatial memory and long-term potentiation against chronic restraint stress

Bahari

Jangravi

Hatef

et al. 2023

Behavioural Pharmacology

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Stress contributes to numerous psychopathologies, including memory impairment, and threatens one’s well-being. It has been reported that creatine supplementation potentially influences cognitive processing. Hence, in this study, we examined the effects of creatine supplementation on memory, synaptic plasticity, and neuronal arborization in the CA1 region of the hippocampus in rats under chronic restraint stress (CRS). Thirty-two adult male Wistar rats (8 weeks old) weighing 200–250 g were randomly divided into four groups (n = 8/per group): control, stress, creatine, and stress + creatine. CRS was induced for 6 h per day for 14 days, and creatine supplementation was carried out by dissolving creatine (2 g/kg body weight per day) in the animals’ drinking water for 14 days. We used the Barnes maze and shuttle box for spatial and passive avoidance memory examination. The in-vivo field potential recording and Golgi-Cox staining were also used to investigate long-term potentiation (LTP) and dendrite arborization in the CA1 pyramidal neurons. Chronic stress impaired spatial memory, dysregulated LTP parameters, and decreased the number of dendrites in the CA1 pyramidal neurons of stressed rats, and creatine supplementation modified these effects in stressed rats. It seems that creatine supplementation can improve spatial memory deficits and synaptic plasticity loss induced by CRS in hippocampal CA1 neurons, possibly by reducing the dendrite arborization damages. However, understanding its mechanism needs further investigation.

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Creatine–facilitated protection of stress caused by disrupted circadian rhythm

Cited by 2 publications

References 51 publications

Creatine Activity as a Neuromodulator in the Central Nervous System

Creatine Activity as a Neuromodulator in the Central Nervous System

Creatine supplementation protects spatial memory and long-term potentiation against chronic restraint stress

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