Creatine for women in pregnancy for neuroprotection of the fetus

Bain, Emily; Wilkinson, Dominic; Middleton, Philippa; Crowther, Caroline A; Dickinson, Hayley; Walker, David

doi:10.1002/14651858.cd010846

Cited by 3 publications

(3 citation statements)

References 34 publications

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“…Creatine supplementation of the maternal diet is consistent with conservative management and would not interfere with the increased surveillance of such high-risk patients that is now standard clinical practice. The absence of any clinical trial at the present time of creatine supplementation in human pregnancy is an obvious barrier to the implementation of this treatment, although a trial of creatine for neuroprotection of the human fetus at term has recently been proposed [ 127 ]. Uterine smooth muscle contains remarkably low levels of creatine, and ATP and phosphocreatine are readily depleted by uterine activity [ 128 ].…”

Section: Reviewmentioning

confidence: 99%

Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy

Dickinson

Ellery

Ireland

et al. 2014

BMC Pregnancy Childbirth

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While the use of creatine in human pregnancy is yet to be fully evaluated, its long-term use in healthy adults appears to be safe, and its well documented neuroprotective properties have recently been extended by demonstrations that creatine improves cognitive function in normal and elderly people, and motor skills in sleep-deprived subjects. Creatine has many actions likely to benefit the fetus and newborn, because pregnancy is a state of heightened metabolic activity, and the placenta is a key source of free radicals of oxygen and nitrogen. The multiple benefits of supplementary creatine arise from the fact that the creatine-phosphocreatine [PCr] system has physiologically important roles that include maintenance of intracellular ATP and acid–base balance, post-ischaemic recovery of protein synthesis, cerebral vasodilation, antioxidant actions, and stabilisation of lipid membranes. In the brain, creatine not only reduces lipid peroxidation and improves cerebral perfusion, its interaction with the benzodiazepine site of the GABAA receptor is likely to counteract the effects of glutamate excitotoxicity – actions that may protect the preterm and term fetal brain from the effects of birth hypoxia. In this review we discuss the development of creatine synthesis during fetal life, the transfer of creatine from mother to fetus, and propose that creatine supplementation during pregnancy may have benefits for the fetus and neonate whenever oxidative stress or feto-placental hypoxia arise, as in cases of fetal growth restriction, premature birth, or when parturition is delayed or complicated by oxygen deprivation of the newborn.

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Section: Reviewmentioning

confidence: 99%

Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy

Dickinson

Ellery

Ireland

et al. 2014

BMC Pregnancy Childbirth

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“…Creatine (Cr) is a simple guanidine compound which is absorbed in the tissues via the creatine transporter and stored as creatine or phosphocreatine. Phosphocreatine is readily converted to creatine via creatine kinase in a reversible reaction which yields a high energy phosphate allowing the conversion of adenosine diphosphate (ADP) to adenosine triphosphate (ATP) (Bain et al 2013). Therefore, the Cr serves as an energetic buffer and through the Creatine/Phosphocreatine (PCr)/Creatine kinase (CK) system, and plays a critical role in the ATP metabolism of neurons.…”

Section: Therapy Focused On Metabolic Energy Levels With Creatinementioning

confidence: 99%

“…It also has the potential to suppress the generation of free oxygen radicals in the central nervous system that causes cell damage and inactivation of CK (Yar et al 2015). In addition, in neurode-generative animal models, creatine supplementation has been shown to reduce the oxidative stress, improve the brain functioning and attenuate the neuronal disintegration (Iqbal et al 2015) and also improves the recovery of the cerebral blood flow after the cessation of a hypoxic episode (Bain et al 2013). Hypoxic-ischaemic models of neonatal brain damage in rodents have provided support for the neuroprotective effects of creatine.…”

Section: Therapy Focused On Metabolic Energy Levels With Creatinementioning

confidence: 99%

Treatments and therapeutic protocols for the recovery of an asphyxiated new-born: A review of pre-clinical and clinical studies in human neonates and in different animal models

Islas-Fabila¹,

Orozco-Gregorio²,

Roldán-Santiago³

et al. 2022

Vet. Med. - Czech

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The objective of this review is to ascertain the advantages and disadvantages of several treatments and therapeutic protocols that have been used for the prevention and treatment of perinatal asphyxia in human neonates and in different animal models. Perinatal asphyxia is one of the main causes of mortality worldwide and is an important factor in triggering physio-metabolic disorders that result in serious neurological consequences and learning disorders not only in human foetuses and neonates, but also in animals. In recent years, the search for new pharmacological protocols to prevent and reverse physio-metabolic disorders and brain damage derived from perinatal asphyxia has been and continues to be the subject of intense research. Currently, within these pharmacological protocols, therapeutic strategies have been evaluated that use respiratory and hormonal stimulants, as well as hypothermic therapies in combination with other putative neuroprotective agents. Similarly, energy supplements have been evaluated with the objective of preventing perinatal asphyxia and treating new-borns with this condition, and to decrease the incidence of neonatal and foetal deaths associated with it. However, despite these promising advances, this pathology has persisted, since the administration of these therapies in low doses may not exert a neuroprotective effect or, in high doses, can trigger adverse effects (such as reduced cardiac contractility, reduced cerebral blood flow, poor perfusion, sympathetic and neuroendocrine stimulation, and increased blood viscosity) in human foetuses and neonates as well as in different animal models (rats, piglets, sheep and rabbits). Therefore, it is important to determine the minimum effective dose with which these therapies exert a neuroprotective effect, as well as the mode of administration, the duration of therapy, etc. Therefore, until a powerful strategy is found to improve the consequences of suffocation, this topic will continue to be the subject of intensive research in the future.

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Prevención Prenatal De Daño Neurológico en Prematuro Extremo

Quiroz

2016

Revista Médica Clínica Las Condes

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Creatine for women in pregnancy for neuroprotection of the fetus

Cited by 3 publications

References 34 publications

Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy

Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy

Treatments and therapeutic protocols for the recovery of an asphyxiated new-born: A review of pre-clinical and clinical studies in human neonates and in different animal models

Prevención Prenatal De Daño Neurológico en Prematuro Extremo

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