Creatine or guanidinoacetic acid? Which is more effective at enhancing growth, tissue creatine stores, quality of meat, and genes controlling growth/myogenesis in Mulard ducks

Ibrahim, Doaa; Sayed, Rania; Abdelfattah‐Hassan, Ahmed; Morshedy, Alaa M.

doi:10.1080/09712119.2019.1590205

Cited by 34 publications

(33 citation statements)

References 35 publications

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“…Dietary GAA has obtained interest to promote higher muscle creatine levels (Majdeddin et al, 2018;Ibrahim et al, 2019), which, in turn, have been associated with improved energetics (Ostojic, 2017;Sadra et al, 2018) and significant increases of high phosphate energy metabolites in broilers supplemented with GAA (Michiels et al, 2012;De Groot et al, 2018;Majdeddin et al, 2018). Improvements in energy utilization have been related to better feed utilization (Khajali et al, 2020).…”

Section: Gaa Used As Feed Additive For Poultrymentioning

confidence: 99%

“…In the same way, Nasiroleslami et al (2018) had reported higher CK activity in GAA-supplemented broilers than in the control group. In a more recent publication, Ibrahim et al (2019) demonstrate that dietary supplementation of GAA plus 0.4% methionine (GAA + 0.4% Met) increased carcass and breast meat yield and improved plasma and muscle creatine more than dietary creatine itself in mulard ducks.…”

Section: Gaa Used As Feed Additive For Poultrymentioning

confidence: 99%

“…The degree of responses to GAA supplementation in live performance, breast meat yield, and muscle myopathy have varied by dietary levels of energy (Abudabos et al, 2014;Sadra et al, 2018) and nutrients such as Arg, Met, folic acid, vitamin E (Wyss and Kaddurah-Daouk, 2000;Dilger et al, 2013;De Groot et al, 2019;Ibrahim et al, 2019;Majdeddin et al, 2019;Khajali et al, 2020) and minerals (Vargas, 2019). The GAA or creatine action always depends on the dietary level of other nutrients to influence muscle metabolism due to its regulatory pathways (Figure 1).…”

Section: The Potential Of Gaa To Reduce Myopathies In Poultrymentioning

confidence: 99%

“…These beneficial results of GAA on WB incidence and severity could be explained by its role on reducing insulin resistance, sparing Arg to increase vasodilation, improving antioxidant capacity (Ostojic, 2015a), and the energetic balance in muscles due to an increase in muscle creatine and as such help supply ATP and proper muscle function during growth (Baldi et al, 2020). Ibrahim et al (2019) observed that GAA + 0.4% Met was superior to creatine to enhance gene expression of insulin growth factor-1, growth hormone, and muscle myogenin and downregulate myostatin in mulard ducks. These two hormones and two muscle transcription factors are affected in myopathies (Vignale et al, 2017;Brothers et al, 2019).…”

Section: Parametermentioning

confidence: 99%

“…Therefore, the positive effects of GAA on its regulation could aid in mitigating moderate WB. Ibrahim et al (2019) also indicated that a possible shortage of methyl groups could be induced by long-term GAA supplementation in ducks, which could impair protein synthesis unless more methionine is added to the feed. In diets based on sorghum, the lower Arg, and Met digestibility as a consequence of kafirin and tannin presence could reduce the efficacy of GAA (Córdova-Noboa et al, 2018a).…”

Section: Parametermentioning

confidence: 99%

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The Potential of Guanidino Acetic Acid to Reduce the Occurrence and Severity of Broiler Muscle Myopathies

Oviedo-Rondón

Córdova-Noboa

2020

Front. Physiol.

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Guanidinoacetic acid (GAA) is the biochemical precursor of creatine, which, in its phosphorylated form, is an essential high-energy carrier in the muscle. Although creatine has limited stability in feed processing, GAA is well established as a source of creatine in the animal feed industry. Published data demonstrate beneficial effects of GAA supplementation on muscle creatine, energy compounds, and antioxidant status, leading to improvements in broiler body weight gain, feed conversion ratio, and breast meat yield. Although increases in weight gain and meat yield are often associated with wooden breast (WB) and other myopathies, recent reports have suggested the potential of GAA supplementation to reduce the occurrence and severity of WB while improving breast meat yield. This disorder increases the hardness of the Pectoralis major muscle and has emerged as a current challenge to the broiler industry worldwide by impacting meat quality. Genetic selection, fast-growth rates, and environmental stressors have been identified to be the main factors related to this myopathy, but the actual cause of this disorder is still unknown. Creatine supplementation has been used as a nutritional prescription in the treatment of several muscular myopathies in humans and other animals. Because GAA is a common feed additive in poultry production, the potential of GAA supplementation to reduce broiler myopathies has been investigated in experimental and commercial scenarios. In addition, a few studies have evaluated the potential of creatine in plasma and blood enzymes related to creatine to be used as potential markers for WB. The evidence indicates that GAA could potentially minimize the incidence of WB. More data are warranted to understand the factors affecting the potential efficacy of GAA to reduce the occurrence and severity of myopathies.

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Section: Gaa Used As Feed Additive For Poultrymentioning

confidence: 99%

Section: Gaa Used As Feed Additive For Poultrymentioning

confidence: 99%

Section: The Potential Of Gaa To Reduce Myopathies In Poultrymentioning

confidence: 99%

Section: Parametermentioning

confidence: 99%

Section: Parametermentioning

confidence: 99%

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The Potential of Guanidino Acetic Acid to Reduce the Occurrence and Severity of Broiler Muscle Myopathies

Oviedo-Rondón

Córdova-Noboa

2020

Front. Physiol.

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Effects of guanidinoacetic acid and complex antioxidant supplementation on growth performance, meat quality, and antioxidant function of broiler chickens

Zhao

Xing

et al. 2021

J Sci Food Agric

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BACKGROUND This study was conducted to evaluate the effects of adding guanidinoacetic acid (GAA), or complex antioxidant (CA), or their combination, in diets on the growth performance, carcass traits, meat quality, and antioxidant capacity of broilers. A total of 192 25‐day‐old broilers were assigned to a 2 × 2 factorial design including two dietary supplements at two different levels, in which the main effects were the addition of GAA (0 or 600 mg kg−1) and CA (0 or 150 mg kg−1). This trial lasted for 18 days. RESULTS Compared with the control group, the GAA group, CA group, and GAA + CA group, decreased feed conversion ratio by 7.02%, 6.58%, and 11.40%, respectively. Guanidinoacetic supplementation increased eviscerated yield, pH24h (P < 0.05). Complex antioxidant supplementation increased the a* values (P < 0.05). The combination of GAA and CA did not affect the carcass traits and meat quality. Guanidinoacetic acid alone and CA alone and combined with GAA and CA decreased the reactive oxygen species (ROS) level and malonaldehyde (MDA) content (P < 0.05), and the GAA + CA group had the lowest ROS level and MDA content of broilers. CONCLUSION Dietary supplementation of GAA, CA or their combination had beneficial effects on growth performance and breast antioxidant capacity, and the combination of GAA and CA could exert a synergistic effect in improving antioxidant capacity. © 2020 Society of Chemical Industry

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Long-term exposure to lead nitrate and zinc sulfate Nile tilapia impact the Aeromonas hydrophila treatment

Sherif,

Okasha,

Kassab

et al. 2024

Mol Biol Rep

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Background Pollution with heavy metals (HMs) is time- and concentration-dependent. Lead and zinc pollute the aquatic environment, causing severe health issues in aquatic animals. Materials and methods Nile tilapia, the predominant cultured fish in Egypt, were experimentally exposed to 10% of LC50 of lead nitrate (PbNO3) and zinc sulfate (ZnSO4). Samples were collected in three different periods, 4, 6, and 8 weeks, in addition to a trial to treat the experimental fish infected with Aeromonas hydrophila, with an antibiotic (florfenicol). Results Liver enzymes were linearly upsurged in a time-dependent manner in response to HMs exposure. ALT was 92.1 IU/l and AST was 82.53 IU/l after eight weeks. In the eighth week of the HMs exposure, in the hepatic tissue, the levels of glutathione peroxidase (GPx), catalase (CAT), and metallothionein (MT) were increased to 117.8 U/mg prot, 72.2 U/mg prot, and 154.5 U/mg prot, respectively. On exposure to HMs, gene expressions of some cytokines were linearly downregulated in a time-dependent manner compared to the control. After four weeks of exposure to the HMs, the oxidative burst activity (OBA) of immune cells was decreased compared to the control 9.33 and 10.3 cells, respectively. Meanwhile, the serum bactericidal activity (SBA) significantly declined to 18.5% compared to the control 32.6% after eight weeks of exposure. Clinical signs of A. hydrophila infection were exaggerated in polluted fish, with a mortality rate (MR) of 100%. The re-isolation rate of A. hydrophila was decreased in fish treated with florfenicol regardless of the pollution impacts after eight weeks of HMs exposure. Conclusion It could be concluded that the immune suppression and oxidative stress resulting from exposure to HMs are time-dependent. Clinical signs and post-mortem lesions in polluted fish infected with A. hydrophila were prominent. Infected-Nile tilapia had weak responses to florfenicol treatment due to HMs exposure.

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Creatine or guanidinoacetic acid? Which is more effective at enhancing growth, tissue creatine stores, quality of meat, and genes controlling growth/myogenesis in Mulard ducks

Cited by 34 publications

References 35 publications

The Potential of Guanidino Acetic Acid to Reduce the Occurrence and Severity of Broiler Muscle Myopathies

The Potential of Guanidino Acetic Acid to Reduce the Occurrence and Severity of Broiler Muscle Myopathies

Effects of guanidinoacetic acid and complex antioxidant supplementation on growth performance, meat quality, and antioxidant function of broiler chickens

Long-term exposure to lead nitrate and zinc sulfate Nile tilapia impact the Aeromonas hydrophila treatment

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