Creatine phosphokinase values during isotretinoin treatment for acne

Abstract

In conclusion, marked hyperCPKemia with or without muscle-related complaints in isotretinoin-treated patients with acne is a benign phenomenon; therefore, it is logical to reserve measurement of CPK levels as well as renal tests for cases with severe muscle pain.

Preventing and Managing the Side Effects of Isotretinoin

“…CPK is not pathognomonic to isotretinoin induced myalgias and management by obtaining CPK levels is not indicated unless there is severe muscular pain. 60 …”

Isotretinoin: efficacy and safety (literature review)

“…Значимое повышение фермента (более 5000 МЕ/л) наблюдает-ся относительно редко (не более чем у 1,5% пациен-тов). Причем последние, как правило, имеют высо-кий уровень физической активности, а также миал-гии [60]. Важным является тот факт, что повышение креатинфосфокиназы является транзиторным, нор-мализуется в течение 2 нед при снижении уровня фи-зической активности [56,57].…”

Monitor patients receiving systemic retinoids regularly for neuromuscular adverse events

“…[1] Acute rhabdomyolysis is a severe and potentially dangerous adverse effect, which can lead to acute renal failure if left untreated. [22] y but clinical significance often unclear Serum CPK levels in patients receiving isotretinoin have been reported as elevated in the presence or absence of myopathy, [20,23,24] and normal in patients with clinical symptoms of myopathy. [22] y but clinical significance often unclear Serum CPK levels in patients receiving isotretinoin have been reported as elevated in the presence or absence of myopathy, [20,23,24] and normal in patients with clinical symptoms of myopathy.…”

“…[1] It is characterized by generalized muscle pain, fatigue, profound weakness, an increase in serum CPK levels of 5-fold or greater and, frequently, myoglobinuria. [21] Retrospective series have shown elevated CPK levels in 5.6%, [24] 37.3% [23] and 41.0% [17] of isotretinoin recipients but only two occurrences of rhabdomyolysis, both reversible on drug discontinuation, have been reported. [21] Retrospective series have shown elevated CPK levels in 5.6%, [24] 37.3% [23] and 41.0% [17] of isotretinoin recipients but only two occurrences of rhabdomyolysis, both reversible on drug discontinuation, have been reported.…”