Creatine supplementation for patients with COPD receiving pulmonary rehabilitation: A systematic review and meta‐analysis

Al-Ghimlas, Fahad; Todd, D.

doi:10.1111/j.1440-1843.2010.01770.x

Cited by 29 publications

(15 citation statements)

References 49 publications

(133 reference statements)

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“…33 Although Cr displays several beneficial therapeutic effects, 2,[12][13][14][15][16]20,21,34 other studies have also found that Cr supplementation does not have a beneficial effect on the respiratory system during respiratory diseases. 15,[35][36][37] This study, however, indicates that Cr supplementation presents beneficial effects after lung I/R injury, including improvements in lung mechanics and inflammation. These contradictory findings in the context of the respiratory diseases are probably related to the pathophysiologic differences between the respiratory diseases under study (i.e., chronic obstructive pulmonary diseases vs acute lung injury).…”

Section: Discussionmentioning

confidence: 51%

Creatine supplementation attenuates pulmonary and systemic effects of lung ischemia and reperfusion injury

Almeida

Oliveira-Júnior

Souza

et al. 2016

The Journal of Heart and Lung Transplantation

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Section: Discussionmentioning

confidence: 51%

Creatine supplementation attenuates pulmonary and systemic effects of lung ischemia and reperfusion injury

Almeida

Oliveira-Júnior

Souza

et al. 2016

The Journal of Heart and Lung Transplantation

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“…Small pilot investigations have suggested potential benefits of whey protein and carnitine, but had insufficient statistical power for wider conclusions to be drawn. Three trials have tested the effect of creatine supplementation during exercise training in COPD with no consistent positive effect, as confirmed by a subsequent systematic review and meta-analysis [105]. In a group of overall non-wasted COPD patients, protein and carbohydrate supplementation after resistance exercise did not augment functional or molecular exercise responses [106].…”

Section: Nutrition As Ergogenic Aidmentioning

confidence: 99%

Nutritional assessment and therapy in COPD: a European Respiratory Society statement

et al. 2014

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Nutrition and metabolism have been the topic of extensive scientific research in chronic obstructive pulmonary disease (COPD) but clinical awareness of the impact dietary habits, nutritional status and nutritional interventions may have on COPD incidence, progression and outcome is limited. A multidisciplinary Task Force was created by the European Respiratory Society to deliver a summary of the evidence and description of current practice in nutritional assessment and therapy in COPD, and to provide directions for future research. Task Force members conducted focused reviews of the literature on relevant topics, advised by a methodologist. It is well established that nutritional status, and in particular abnormal body composition, is an important independent determinant of COPD outcome. The Task Force identified different metabolic phenotypes of COPD as a basis for nutritional risk profile assessment that is useful in clinical trial design and patient counselling. Nutritional intervention is probably effective in undernourished patients and probably most when combined with an exercise programme. Providing evidence of costeffectiveness of nutritional intervention is required to support reimbursement and thus increase access to nutritional intervention. Overall, the evidence indicates that a well-balanced diet is beneficial to all COPD patients, not only for its potential pulmonary benefits, but also for its proven benefits in metabolic and cardiovascular risk. @ERSpublications Metabolism and nutrition: shifting paradigms in COPD management

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“…In view of this, a number of RCTs of creatine supplementation combined with respiratory rehabilitation have been conducted in COPD patients [58,59,60]. Meta-analyses of these RCTs have, however, failed to show any add-on effect of creatine supplementation in improving the muscle strength of the upper and lower extremities, exercise tolerance (shuttle walk test and 6MWD) or HRQoL (SGRQ score) in COPD patients undergoing respiratory rehabilitation [61]. …”

Section: Creatine Intakementioning

confidence: 99%

Undernutrition in Patients with COPD and Its Treatment

et al. 2013

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Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder of the lung and whole body caused mainly by tobacco smoking. Patients with advanced COPD are in a state of undernutrition, referred to as pulmonary cachexia; the exercise performance and quality of life (QOL) of these patients are deteriorated, the vital prognosis is unfavorable, and the medico-economic burden posed by poorly nourished COPD patients is high. The mainstays of COPD treatment are pharmacotherapy, mainly with bronchodilators, and non-pharmacotherapeutic approaches such as respiratory rehabilitation and nutrition counseling. Nutritional supplement therapy, consisting primarily of high calorie intake, has been demonstrated to be effective for maintaining and improving the muscle strength and exercise tolerance in poorly nourished COPD patients. The efficacy of intake of various nutrients, besides a high calorie intake, for amelioration of the disease state of COPD has also been reported. The roles of adipokines in the pathophysiology of COPD have begun to receive attention recently, and not only their regulatory effects on appetite and nutritional status, but also their influence on systemic inflammation have been increasingly clarified. We review the papers on COPD and nutrition and discuss the role of nutritional supplement therapy in the treatment of COPD.

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Creatine supplementation for patients with COPD receiving pulmonary rehabilitation: A systematic review and meta‐analysis

Abstract: Creatine supplementation does not improve exercise capacity, muscle strength or HR-QoL in patients with COPD receiving PR. However, important limitations were identified in the quality of the available evidence, suggesting that further research is required in this area.

Cited by 29 publications

References 49 publications

Creatine supplementation attenuates pulmonary and systemic effects of lung ischemia and reperfusion injury

Creatine supplementation attenuates pulmonary and systemic effects of lung ischemia and reperfusion injury

Nutritional assessment and therapy in COPD: a European Respiratory Society statement

Undernutrition in Patients with COPD and Its Treatment

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