Nurse practitioners (NPs) who are culturally competent can enrich patient care, reduce health disparities, and improve health outcomes. Research that examines NP practice as it relates to the culturally competent care of lesbian, gay, bisexual, and transgender (LGBT) patients has been lacking in the literature. To address this gap, an exploratory qualitative descriptive design was used to explore NP experiences with LGBT patients. Data were collected via semi-structured interviews with 22 NPs. Inductive analysis was used to identify, analyze, and report themes within the data. Key findings were that LGBT patients were generally not seen as a distinct cultural group with specific health needs and that NP participants were unclear about the definition or principles of cultural competence as it relates to LGBT persons. Most NPs were not using a model of cultural competence to guide their practice. Instead, they utilized strategies that primarily revolved around the development and maintenance of the therapeutic nurse -patient relationship. These findings have implications for patient outcomes, as well as education, practice, and research. Culturally Competent Care of LGBT Patients: The NP Experience 54 Dana Manzer, Lucia O'Sullivan and Shelley Doucet and injury; health assessment and diagnosis; therapeutic management; and professional role, responsibility and accountability [2].NPs are employed in a variety of practice settings, including community health centers and collaborative family practice; urgent care and emergency departments; mental health and addiction services; correctional services; long-term care; and non-government agencies [3]. An individual's first point of contact or primary provider of health care may be an NP. The hallmark of NP practice is holistic, patient-centered care that assists persons of diverse cultures, races, religions, genders and ethnicities in achieving, maintaining, and enhancing their health and wellbeing [2]. Holism in nursing is grounded in caring. It is foundational to the development of the nurse-patient relationship, and a fundamental component of the Canadian Code of Ethics for Registered Nurses which outlines standards for the safe, competent, and ethical care of patients. Originally adopted in 1984, the code was revised in 2017 to reflect, among other things, the increasing diversity among Canadians accessing the health care system, and the impact of social inequities on health inequities [4].NPs have a long history of providing care to diverse populations who live within vastly different social contexts, and the impact of determinants of health are routinely incorporated into NP practice. Patients experience a variety of acute and chronic health needs over their lifespan, and possess varying levels of health management and coping abilities. However, all patients should expect to receive ethical, competent, and compassionate care from their health care provider, that acknowledges and recognizes the circumstances which influence a person's health and well-being. A key com...