Creating and exploring carboxymethyl cellulose aerogels as drug delivery devices

Yu, Sujie; Budtova, Tatiana

doi:10.1016/j.carbpol.2024.121925

Cited by 15 publications

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Emerging Functional Porous Scaffolds for Liver Tissue Engineering

Wang,

Huang,

Chen

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Liver tissue engineering holds promising in synthesizing or regenerating livers, while the design of functional scaffold remains a challenge. Owing to the intricate simulation of extracellular matrix structure and performance, porous scaffolds have demonstrated advantages in creating liver microstructures and sustaining liver functions. Currently, various methods and processes have been employed to fabricate porous scaffolds, manipulating the properties and morphologies of materials to confer them with unique supportive functions. Additionally, scaffolds must also facilitate tissue growth and deliver cells, possessing therapeutic or regenerative effects. In this review, it is initially outline typical procedures for fabricating porous scaffolds and showcase various morphologies of microstructures. Subsequently, it is delved into the forms of cell loading in porous scaffolds, including scaffold‐based, scaffold‐free, and synergetic or bioassembly approaches. Lastly, the utilization of porous scaffolds in liver diseases, offering significant insights and future implications for liver regeneration research in tissue engineering is explored.

show abstract

Emerging Functional Porous Scaffolds for Liver Tissue Engineering

Wang,

Huang,

Chen

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

Biomedical Potential of Cellulose: Current Trends and Future Directions

Jafari,

Al‐Ostaz,

Nouranian

2024

Polymers for Advanced Techs

View full text Add to dashboard Cite

The exploration of cellulose, a natural polysaccharide derived from renewable biomass, has seen significant advancements in recent years due to its biocompatibility, biodegradability, and versatility. This review paper comprehensively covers the latest developments in cellulose and its derivatives as functional biomaterials for various biomedical applications. Emphasis is placed on the intrinsic properties of cellulose, such as its mechanical strength, thermal stability, and chemical modifiability, which enable its wide‐ranging use in drug delivery systems, wound dressings, tissue engineering, and biosensors. The article further delves into the modification techniques—such as oxidation, esterification, and etherification—that enhance cellulose's performance, allowing it to be fine‐tuned for specialized medical applications, including the creation of scaffolds for tissue regeneration and smart materials for responsive drug release. Additionally, the hybridization of cellulose with inorganic materials offers potential in developing materials with superior antimicrobial properties and improved mechanical characteristics. This review also addresses the challenges in cellulose processing, particularly concerning optimizing its structure for specific applications, while highlighting future opportunities in the field of personalized medicine and intelligent healthcare devices. By examining both the current innovations and future trends, this review highlights the growing importance of cellulose as a sustainable and versatile resource in the biomedical industry.

show abstract

Biomedical Applications of Aerogels: Therapeutic Potential, Safety, and Future Research Directions

Jaiswal,

Yadav,

Kumar

2024

Polymers for Advanced Techs

View full text Add to dashboard Cite

Aerogels are garnering considerable attention in biomedical fields due to their unique physicochemical properties. These materials are noted for their low density, high porosity, and customizable pore structures, making them highly suitable for applications such as drug delivery, regenerative medicine, and wound healing. They provide excellent platforms for loading drugs and active biomolecules. Consequently, research into the therapeutic potential of aerogels has surged, both in vitro and in vivo, reflecting an increased acknowledgment of their biomedical promise. Despite this growing body of research, detailed data on the in vivo performance and safety of aerogels remain sparse. While polymer‐based, silica‐based, and hybrid aerogels are generally deemed safe, there is still a lack of comprehensive understanding regarding their acute, subacute, and chronic toxicity. This review presents a thorough examination of the biomedical applications of aerogels, exploring both conventional uses and innovative applications like decontamination. We assess the biological impacts of aerogels on cells and organisms, focusing on their therapeutic effectiveness and safety. Through this detailed review, we aim to highlight the current state of aerogel research in the biomedical field and pinpoint key areas where further investigation is needed to ensure their safe and effective use in medical applications.

show abstract

Creating and exploring carboxymethyl cellulose aerogels as drug delivery devices

Cited by 15 publications

References 54 publications

Emerging Functional Porous Scaffolds for Liver Tissue Engineering

Emerging Functional Porous Scaffolds for Liver Tissue Engineering

Biomedical Potential of Cellulose: Current Trends and Future Directions

Biomedical Applications of Aerogels: Therapeutic Potential, Safety, and Future Research Directions

Contact Info

Product

Resources

About