New technology based firms (NTBFs) play a major role in the development and commercialisation of new technologies and the development of national economies. Using an entrepreneurship-in-networks approach, this paper examines the early stages of the development of these companies, i.e. from opportunity recognition through opportunity exploration. Case study data was collected on 22 NTBFs from six European universities. The findings highlight specific needs related to five functional areas of importance to NTBFs, namely: R&D, market development and sales, organisation and governance, finance and administration, and production/operation. These needs are reported for both the pre-and post-foundation phases and can thus be utilised by both entrepreneurs and support agencies to guide the development of NTBFs.