Creating and utilising the Wales Asthma Observatory to support health policy, health service planning and clinical research

Sallakh, Al; Mohammad, Aghajani

doi:10.23889/suthesis.48569

Cited by 1 publication

(2 citation statements)

References 269 publications

(436 reference statements)

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“…I found that not all the studies provided an open link to the list of codes in their manuscripts, including: 1) the Clinical Risk Groups (CRGs) classification system, which may be because 3M CRGs has now been developed into a commercial product [180]; 2) the PMCA, which we wouldn't be able to find easily or straightforwardly (e.g., we searched by author names on different websites to locate the codes of the PMCA [191], which we located at this link: https://www.kpwashingtonresearch.org/our-research/our-scientists/rita-mangione-smith-mdmph/measurement-tools-research-dr-rita-mangione-smith; 3) and the paediatric complex chronic conditions (CCCs) classification system provided a non-open link in the related manuscript to the lists of codes [35]. This illustrates the difficulties that researchers have when attempting to locate some of the published algorithms with their codes.…”

Section: Specific Discussion Pointsmentioning

confidence: 99%

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Repeatable and reusable research - Exploring the needs of users for a Data Portal for Disease Phenotyping

Almowil¹

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Background: Big data research in the field of health sciences is hindered by a lack of agreement on how to identify and define different conditions and their medications. This means that researchers and health professionals often have different phenotype definitions for the same condition. This lack of agreement makes it hard to compare different study findings and hinders the ability to conduct repeatable and reusable research. Objective: This thesis aims to examine the requirements of various users, such as researchers, clinicians, machine learning experts, and managers, for both new and existing data portals for phenotypes (concept libraries). Methods: Exploratory sequential mixed methods were used in this thesis to look at which concept libraries are available, how they are used, what their characteristics are, where there are gaps, and what needs to be done in the future from the point of view of the people who use them. This thesis consists of three phases: 1) two qualitative studies, including one-to-one interviews with researchers, clinicians, machine learning experts, and senior research managers in health data science, as well as focus group discussions with researchers working with the Secured Anonymized Information Linkage databank, 2) the creation of an email survey (i.e., the Concept Library Usability Scale), and 3) a quantitative study with researchers, health professionals, and clinicians. Results: Most of the participants thought that the prototype concept library would be a very helpful resource for conducting repeatable research, but they specified that many requirements are needed before its development. Although all the participants stated that they were aware of some existing concept libraries, most of them expressed negative perceptions about them. The participants mentioned several facilitators that would encourage them to: 1) share their work, such as receiving citations from other researchers; and 2) reuse the work of others, such as saving a lot of time and effort, which they frequently spend on creating new code lists from scratch. They also pointed out several barriers that could inhibit them from: 1) sharing their work, such as concerns about intellectual property (e.g., if they shared their methods before publication, other researchers would use them as their own); and 2) reusing others' work, such as a lack of confidence in the quality and validity of their code lists. Participants suggested some developments that they would like to see happen in order to make research that is done with routine data more reproducible, such as the availability of a drive for more transparency in research methods documentation, such as publishing complete phenotype definitions and clear code lists. Conclusions: The findings of this thesis indicated that most participants valued a concept library for phenotypes. However, only half of the participants felt that they would contribute by providing definitions for the concept library, and they reported many barriers regarding sharing their work on a publicly accessible platform such as the CALIBER research platform. Analysis of interviews, focus group discussions, and qualitative studies revealed that different users have different requirements, facilitators, barriers, and concerns about concept libraries. This work was to investigate if we should develop concept libraries in Kuwait to facilitate the development of improved data sharing. However, at the end of this thesis the recommendation is this would be unlikely to be cost effective or highly valued by users and investment in open access research publications may be of more value to the Kuwait research/academic community.

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Section: Specific Discussion Pointsmentioning

confidence: 99%

“…He discovered high variation in the algorithms used to define asthma (n = 66 different algorithms) across 113 eligible articles. [191].…”

Section: Specific Discussion Pointsmentioning

confidence: 99%

Repeatable and reusable research - Exploring the needs of users for a Data Portal for Disease Phenotyping

Almowil¹

View full text Add to dashboard Cite

show abstract

Creating and utilising the Wales Asthma Observatory to support health policy, health service planning and clinical research

Cited by 1 publication

References 269 publications

Repeatable and reusable research - Exploring the needs of users for a Data Portal for Disease Phenotyping

Repeatable and reusable research - Exploring the needs of users for a Data Portal for Disease Phenotyping

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