In this paper, we offer a commentary on Oman’s article “Mindfulness for Global Public Health: Critical Analysis and Agenda” from the perspective of external environments, be they natural or built spaces. Utilizing the 14 domains of mindfulness and public health identified by Oman, we examine how spatio-environmental concerns are aligned, or have potential synergies with, these dimensions. We consider spatial and environmental qualities and relationships, for example, the presence of nature or a sense of safety, as supportive for public health and formal mindfulness practice, synthesizing a growing evidence base within environmental psychology and design literature. We highlight particular points of alignment, namely the impact of environments on mental health, stress, and attentional qualities. Potential synergies are evident where these domains seek to increase resilience and the sustainability of our planet, communities, and individuals, and through the increasing emphasis on designing places that offer inclusive access to, and direct involvement in, the creation of belief (spirituality) and culture-specific interventions. Although these domains offer the potential for greater holistic research and practice, more interdisciplinary research is needed to bridge gaps and bring this potential into the mainstream.