Creatinine-based estimation of rate of long term renal function loss in lung transplant recipients. Which method is preferable?

Broekroelofs, J.; Stegeman, Coen A.; Navis, Gerjan; Haan, Jacco–Juri de; Bij, Wim van der; Boer, W.J. de; Zeeuw, Dick de; Jong, Paul E. de

doi:10.1016/s1053-2498(99)00133-3

Cited by 37 publications

(26 citation statements)

References 11 publications

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“…This measurement is superior especially in populations such as LTx, where long-term changes in muscle mass confound creatinine-based renal function estimates (23). A comparison of this method with the more widely available eGFR calculations was published in an early subgroup (N = 40) from this cohort in 2000 (23), showing that renal function loss is underestimated by creatinine-derived renal function estimates in LTx recipients. Another strength of this study is the availability of serial CNI trough levels in never smokers and groups of former smokers.…”

Section: Discussionmentioning

confidence: 99%

Former Smoking Is a Risk Factor for Chronic Kidney Disease After Lung Transplantation

Hellemons¹,

Agarwal²,

Bij³

et al. 2011

American Journal of Transplantation

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Chronic kidney disease (CKD) is a common complication after lung transplantation (LTx).Smoking is a risk factor for many diseases, including CKD. Smoking cessation for >6 months is required for LTx enlistment. However, the impact of smoking history on CKD development after LTx remains unclear. We investigated the effect of former smoking on CKD and mortality after LTx. CKD was based on glomerular filtration rate (GFR) ( 125 I-iothalamate measurements). GFR was measured before and repeatedly after LTx. One hundred thirty-four patients never smoked and 192 patients previously smoked for a median of 17.5 pack years. At 5 years after LTx, overall cumulative incidences of CKD-III, CKD-IV and death were 68.5%, 16.3% and 34.6%, respectively. Compared to never smokers, former smokers had a higher risk for CKD-III (hazard ratio [

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Section: Discussionmentioning

confidence: 99%

Former Smoking Is a Risk Factor for Chronic Kidney Disease After Lung Transplantation

Hellemons¹,

Agarwal²,

Bij³

et al. 2011

American Journal of Transplantation

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“…Estimated GFR was calculated with the abbreviated MDRD, which has not been extensively validated in lung or heart-lung transplant patients. It is conceivable that patients with advanced lung disease have low muscle mass such that their serum creatinine and the formulas based on it are grossly inaccurate (46). In addition, knowledge of medication use that might interact with CNI to exacerbate renal dysfunction such as vancomycin and others was not available.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Chronic Kidney Disease in Long-Term Survivors of Lung and Heart-Lung Transplantation

Canales

Youssef

Spong

et al. 2006

American Journal of Transplantation

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Renal insufficiency is common after non-renal organ transplants. The predictors of long-term renal outcomes are not well established. A total of 219 lung and heart-lung transplant recipients surviving more than 6 months after transplantation were studied to determine predictors of time to doubling of serum creatinine and end-stage kidney disease (ESKD) with death as a competing risk. Median follow-up was 79 months (range 9-222 months). Baseline estimated glomerular filtration rate (GFR) was 96.3 ± 34.5 mL/min/ 1.73 m 2 . One hundred twenty-two recipients (55%) doubled their serum creatinine, 16 (7.3%) progressed to ESKD and 143 (65%) died. The majority of recipients who survived >6 years had a GFR < 60 mL/min at both 1 and 7 years. Most of the loss of renal function occurred in the first year post-transplant. Older age at transplant, lower GFR at 1 month and cyclosporine use in the first 6 months predicted shorter time to doubling of serum creatinine when death was handled as a competing risk. Based on this prevalence data and using GFR decay and death as study endpoints, we offer sample size estimates for a prospective, interventional trial that is aimed at slowing or preventing the progression of kidney disease.

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“…9 Recent studies suggest that the formulas are similarly limited in estimating kidney function in lung and heart recipients as well. 12,13 The largest and most comprehensive study of CKD prevalence after solid-organ transplantation used a definition of GFR of Ͻ30 ml/min per 1.73 m 2 body surface area, calculated with the fourvariable MDRD equation. Applying this definition to a data set from the Scientific Registry of Transplant Recipients (SRTR), Ojo et al 1 reported a CKD prevalence at 5 yr after transplantation of 21.3% among intestine recipients, 18.1% among liver recipients, 15.8% among lung recipients, 10.9% among heart recipients, and 6.9% among heart-lung recipients.…”

Section: Prevalence Of Ckd After Nonrenal Organ Transplantationmentioning

confidence: 99%

Chronic Kidney Disease after Nonrenal Solid-Organ Transplantation

Bloom

Reese

2007

Journal of the American Society of Nephrology

164

138

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Creatinine-based estimation of rate of long term renal function loss in lung transplant recipients. Which method is preferable?

Cited by 37 publications

References 11 publications

Former Smoking Is a Risk Factor for Chronic Kidney Disease After Lung Transplantation

Former Smoking Is a Risk Factor for Chronic Kidney Disease After Lung Transplantation

Predictors of Chronic Kidney Disease in Long-Term Survivors of Lung and Heart-Lung Transplantation

Chronic Kidney Disease after Nonrenal Solid-Organ Transplantation

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