Creation of an MRI phantom based on super-paramagnetic nanoparticles of iron oxide (SPIO) for standardization of the conversion of T2 * values in the concentration of iron in the liver

Abstract

In this study the standardization method for T2* maps acquisition on various MR scanners (3T and 1.5T) is proposed. The reproducibility of the obtained T2* values is realized through the MR-compatible phantom containing paramagnetic complex iron oxide nanoparticles. The repeatability of measurements results has shown that the created phantom retains all the required characteristics (homogeneity, stability of concentrations and manifested paramagnetic properties) over a long period of time. The application of standardized T2* values allows to use previously received T2*, [ms] to iron concentrations in the dry substance of the liver (LIC), [mg/ml] conversion formulas for accurate, fast and non-invasive MRI diagnostics of liver iron overload.

Synthesis of Manganese Zinc Ferrite Nanoparticles in Medical-Grade Silicone for MRI Applications

“…The work described herein is motivated by the possibility of employing magnetic silicone nanocomposites as temperature sensors during thermal ablation therapy guided by magnetic resonance imaging (MRI). These materials may also improve MR-tagged implants and MR structural phantoms [ 21 , 22 , 23 ].…”