Creation of gastroenteric anastomosis through natural orifice in rats by magnetic compression technique

Zhang, Miaomiao; Li, Yixing; Pan, Min; Xu, Shuqin; Gai, Jingci; Zhang, Hanzhi; An, Yingfeng; Shi, Aihua; Lyu, Yi; Yan, Xiaopeng

doi:10.1007/s00464-022-09257-z

Cited by 10 publications

(7 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MCA relies on magnetic force to form an anastomosis without the use of sutures or staples 9 . The underlying principle of MCA is that the compressed tissue between two magnets undergoes ischemia, necrosis, and shedding, whereas the adjacent tissue undergoes adhesion, repair, and healing 10 . Presently, the application of MCA in the digestive tract includes esophageal anastomosis 11 , gastrointestinal anastomosis 12 , cholangiojejunostomy 13 , intestinal anastomosis 14 , and colonic anastomosis 15 .…”

Section: Introductionmentioning

confidence: 99%

“…To explore a novel palliative treatment method for MGOO, open gastrojejunostomy has previously been performed in rats based on the principle of MCA 16 . For the further investigation of minimally invasive surgical methods, magnets were inserted through the mouth and anus to complete rat gastrocolic anastomosis through the natural lumen 10 . Inspired by previous studies, a deformable self-assembling magnetic anastomosis ring (DSAMAR) suitable for gastrojejunostomy in large animals was designed, and its feasibility was confirmed by performing animal experiments in this study.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Feasibility experiment of a novel deformable self-assembled magnetic anastomosis ring (DSAMAR) for gastrointestinal anastomosis through a natural orifice

Zhang,

Zhong,

et al. 2024

Sci Rep

Self Cite

View full text Add to dashboard Cite

Although the application of magnetic compression anastomosis is becoming increasingly widespread, the magnets used in earlier studies were mostly in the shape of a whole ring. Hence, a deformable self-assembled magnetic anastomosis ring (DSAMAR) was designed in this study for gastrointestinal anastomosis. Furthermore, its feasibility was studied using a beagle model. The designed DSAMAR comprised 10 trapezoidal magnetic units. Twelve beagles were used as animal models, and DSAMARs were inserted into the stomach and colon through the mouth and anus, respectively, via endoscopy to achieve gastrocolic magnamosis. Surgical time, number of failed deformations, survival rate of the animals, and the time of magnet discharge were documented. A month later, specimens of the anastomosis were obtained and observed with the naked eye as well as microscopically. In the gastrocolic anastomosis of the 12 beagles, the procedure took 65–120 min. Although a deformation failure occurred during the operation in one of the beagles, it was successful after repositioning. The anastomosis was formed after the magnet fell off 12–18 days after the operation. Naked eye and microscopic observations revealed that the anastomotic specimens obtained 1 month later were well-formed, smooth, and flat. DSAMAR is thus feasible for gastrointestinal anastomosis under full endoscopy via the natural orifice.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Feasibility experiment of a novel deformable self-assembled magnetic anastomosis ring (DSAMAR) for gastrointestinal anastomosis through a natural orifice

Zhang,

Zhong,

et al. 2024

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…Magnamosis, which has been studied and applied in medicine for over 40 years, is finding increasing use in both academic and medical settings. Past researchers have found that magnamosis can be applied for any anastomosis involving a lumen in the digestive tract, including esophageal 11 , esophagogastric 12 , gastrojejunal 13 , 14 , small intestine 15 , colon 16 , and biliary-enteric anastomosis 17 . Magnamosis can be used for vascular anastomosis 18 , 19 as well as for creating therapeutic 20 and pathological 21 fistulas.…”

Section: Introductionmentioning

confidence: 99%

Application of Y–Z deformable magnetic ring for recanalization of transanal single-access rectal stricture

Zhang,

Zhuang,

Mao

et al. 2024

Sci Rep

Self Cite

View full text Add to dashboard Cite

Magnetic compression anastomosis has been reported to have remarkable clinical outcomes. Here, we tested the applicability of a Y–Z deformable magnetic ring (DMR) for non-surgical manipulation of rectal stenosis (RS) in a beagle dog model under a transanal single-access condition. RS was modeled in 8 beagle dogs using partial ligation with silk thread. Under X-ray guidance, the Y–Z DMR was positioned at the proximal and distal ends of the RS, and the magnetic ring was bent into an “O” shape, such that the two rings were magnetically attracted. Operation time, complications during or after operation, and discharge time of the magnetic rings were recorded. The anastomosis bursting pressure was measured two weeks after removing the rings, and its formation was assessed through gross and histological examination. Partial ligation with a silk thread successfully established the canine RS model. After Y–Z DMR installation, the magnetic ring was successfully reconfigured from an “S” to an “O” shape. Strong attraction existed between the rings. The operation time was 9–15 min (average: 11.75 ± 1.98 min). No rectal bleeding or perforation occurred during or after operation. The ring was naturally expelled 7–10 days after surgery. A pressure of > 300 mmHg was recorded at the point of anastomosis rupture. The rectal anastomosis appeared to have healed properly on the surface, which was confirmed histologically, signifying the success of this procedure. A Y–Z DMR facilitated the successful recanalization of transanal single-channel RS without needing surgery in an animal model.

show abstract

“…MS is used to achieve such functions as complete tissue compression, organ anchoring, lumen navigation, gap expansion, controllable tracing, and directional drive. MS also can be used for digestive tract anastomosis (5)(6)(7)(8), cystostomy (9), establishment of an animal model of tracheoesophageal fistula (10), and vascular anastomosis (11)(12)(13)(14)(15). The magnetic anchor technique (MAT) is an important magnetic surgical technique ( 16) that has been used in laparoscopic surgery (17,18), thoracoscopic surgery (19) and endoscopic submucosal dissection (20,21) and offers the advantages of reducing trauma and optimizing surgical operations.…”

Section: Introductionmentioning

confidence: 99%

Value of a novel Y-Z magnetic totally implantable venous access port in improving the success rate of one-time needle insertion

Zhang,

Lyu,

Wang

et al. 2023

Front. Surg.

Self Cite

View full text Add to dashboard Cite

Background and objectivesA totally implantable venous access port (TIVAP) is a commonly used intravenous infusion device for patients receiving chemotherapy or long-term infusion therapy. To improve the success rate of one-time insertion of the Huber needle, we developed a novel Y-Z magnetic TIVAP (Y-Z MTIVAP), which we produced using three-dimensional printing technology.Materials and methodsThe Y-Z MTIVAP includes a magnetic port body and a magnetic positioning device. For testing, we established four venous port implantation models using the two types of TIVAPs and two implantation depth ranges (≤5 mm and >5 mm). Twenty nurses performed Huber needle puncture with the four models, and we recorded the number of attempts required for successful needle insertion, the operation time, and the operator's satisfaction.ResultsThe success rate for one-time needle insertion with the Y-Z MTIVAP was significantly higher than that with the traditional TIVAP at either depth range (100% vs. 75% at ≤5 mm, p = 0.047; 95% vs. 35% at >5 mm, p < 0.001). With increasing implantation depth, the success rate for one-time insertion was significantly reduced with the traditional TIVAP (75% at ≤5 mm vs. 35% vs. >5 mm, p = 0.025), but the success rate with the Y-Z MTIVAP was not significantly affected (100% vs. 95%, p = 1.000). The operation time with the Y-Z MTIVAP was significantly shorter than that with the traditional TIVAP at either depth range (both p < 0.001), and 90% of operators reported that the Y-Z MTIVAP was superior to the traditional TIVAP.ConclusionsThe theoretical design of Y-Z MTIVAP is feasible, and the preliminary in vitro simulation experiment shows that it can significantly improve puncture success rate and shortened operation time.

show abstract

Creation of gastroenteric anastomosis through natural orifice in rats by magnetic compression technique

Cited by 10 publications

References 26 publications

Feasibility experiment of a novel deformable self-assembled magnetic anastomosis ring (DSAMAR) for gastrointestinal anastomosis through a natural orifice

Feasibility experiment of a novel deformable self-assembled magnetic anastomosis ring (DSAMAR) for gastrointestinal anastomosis through a natural orifice

Application of Y–Z deformable magnetic ring for recanalization of transanal single-access rectal stricture

Value of a novel Y-Z magnetic totally implantable venous access port in improving the success rate of one-time needle insertion

Contact Info

Product

Resources

About