Creation of New Local Anesthetics Based on Quinoline Derivatives and Related Heterocycles

Recent advances in chemistry and therapeutic potential of functionalized quinoline motifs – a review

“…Historically, cinchocaine was the rst local anesthetic to be synthesized from the quinoline-based group. 24 In 1834, quinoline was rst discovered and isolated by Friedlieb Ferdinard Runge from coal tar. 25,26 It belongs to the alkaloid family and is a secondary metabolite under the nitrogen-containing natural products.…”