Creation of Radiofrequency Lesions in a Porcine Model

Raman, Steven S.; Lu, David; Vodopich, Darko J.; Sayre, James; Lassman, Charles

doi:10.2214/ajr.175.5.1751253

Cited by 106 publications

(18 citation statements)

References 11 publications

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“…The transient hyperechoic region represents the microbubbles of water vapour that are a result of tissue vaporization during active heating. Although the monitoring of the echogenic response may be most useful in providing a rapid and convenient approximation of the ablation size, it is not a precise marker because both under- and overestimation of the true extent of coagulation have been reported2526272829. In the present study, we could thus estimate with relative accuracy whether a sufficient and safe margin of ablation could be obtained by placing the thermal monitoring needle at the tissue between the lesion margin and the vital structures perpendicular to the MWA antenna axis.…”

Section: Discussionmentioning

confidence: 99%

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A clinical study of thermal monitoring techniques of ultrasound-guided microwave ablation for hepatocellular carcinoma in high-risk locations

Han

Liang

et al. 2017

Sci Rep

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To confirm the safety and effectiveness of the minimally invasive thermal monitor technique on percutaneous ultrasound-guided microwave ablation (MWA) for hepatocellular carcinoma (HCC) in high-risk locations, a total of 189 patients with 226 HCC nodules in high-risk locations were treated with MWA. The real-time temperature of the tissue between the lesion margin and the vital structures was monitored by inserting a 21G thermal monitoring needle. The major indexes of technical success, technique effectiveness, local tumour progression and complications were observed during the follow-up period. Technical success was acquired in all patients. Technique effectiveness was achieved with one session in 119 lesions based on contrast-enhanced ultrasound (CEUS) 3–5 days after treatment. An additional 95 lesions achieved technique effectiveness at the second session. Within the follow–up period of 6–58 months (median 38 months), the 1-, 2-, 3-, and 4-year local tumour progression rate was 11.1%, 18.1%, 19.1%, and 19.9%, respectively. There were no major complications in all the patients except for the common side effects. These results indicate that the thermal monitor technique can be applied to prevent major complications in vulnerable structures and allow percutaneous MWA to achieve satisfactory technique effectiveness in the treatment of HCC in high-risk locations.

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Section: Discussionmentioning

confidence: 99%

“…This can lead to difficulty ablating tumours under the diaphragm or in other areas where oblique imaging planes are desirable. In addition, the use of CT exposes both the patient and physician to ionizing radiation2627.…”

Section: Discussionmentioning

confidence: 99%

A clinical study of thermal monitoring techniques of ultrasound-guided microwave ablation for hepatocellular carcinoma in high-risk locations

Han

Liang

et al. 2017

Sci Rep

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“…The result of our framework is a fully reconstructed histological lesion, registered into the CT coordinate system. Obviously, that allows a more accurate assessment of the correlation of histological and CT lesion than using comparison of single slices[25] – in particular in the liver where the heat sink effect leads to complex-shaped lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Typically the assessment was based on manually measured size and volume of histological and CT lesion and visual comparison of single slices. [25] Both are obviously inadequate descriptors for typical complex-shaped lesions in the liver. In consequence, the relation between CT features and histology is only weakly defined at the most crucial transition region between alive and dead tissue, the hyperemic rim.…”

Section: Introductionmentioning

confidence: 99%

Interactive registration of 2D histology and 3D CT data for assessment of radiofrequency ablation treatment

Seise

Alhonnoro

Kolesnik

2012

Journal of Pathology Informatics

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Histological investigation of a lesion induced by radiofrequency ablation (RFA) treatment provides ground-truth about the true lesion size, thus verifying the success or failure of the RFA treatment. This work presents a framework for registration of two-dimensional large-scale histological sections and three-dimensional CT data typically used to guide the RFA intervention. The focus is on the developed interactive methods for reconstruction of the histological volume data by fusion of histological and high-resolution CT (MicroCT) data and registration into CT data based on natural feature points. The framework is evaluated using RFA interventions in a porcine liver and applying medically relevant metrics. The results of registration are within clinically required precision targets; thus the developed methods are suitable for validation of the RFA treatment.

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“…However, the use of ultrasound for monitoring thermal ablation therapy in a clinical setting has been hindered by poor contrast between treated and untreated tissue on ultrasound B-mode images. 5 …”

Section: Introductionmentioning

confidence: 99%

Mean Scatterer Spacing Estimation in Normal and Thermally Coagulated Ex Vivo Bovine Liver

Rubert

Varghese

2014

Ultrason Imaging

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The liver has been hypothesized to have a unique arrangement of microvasculature that presents as an arrangement of quasiperiodic scatterers to an interrogating ultrasound pulse. The mean scatterer spacing (MSS) of these quasiperiodic scatterers has been proposed as a useful quantitative ultrasound biomarker for characterizing liver tissue. Thermal ablation is an increasingly popular method for treating hepatic tumors, and ultrasonic imaging approaches for delineating the extent of thermal ablation are in high demand. In this work, we examine the distribution of estimated MSS in thermally coagulated bovine liver and normal untreated bovine liver ex vivo. We estimate MSS by detecting local maxima in the spectral coherence function of radio frequency echoes from a clinical transducer, the Siemens VFX 9L4 transducer operating on an S2000 scanner. We find that normal untreated bovine liver was characterized by an MSS of approximately 1.3 mm. We examined regions of interest 12 mm wide laterally, and ranging from 12 mm to 18 mm axially, in 2 mm increments. Over these parameters, the mode of the MSS estimates was between 1.25 and 1.37 mm. On the other hand, estimation of MSS in thermally coagulated liver tissue yields a distribution of MSS estimates whose mode varied between 0.45 and 1.0 mm when examining regions of interest over the same sizes. We demonstrate that the estimated MSS in thermally coagulated liver favors small spacings because the randomly positioned scatterers in this tissue are better modeled as aperiodic scatterers. The submillimeter spacings result from the fact that this was the most probable spacing to be estimated if the discretely sampled spectral coherence function was a uniformly random two-dimensional function.

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Creation of Radiofrequency Lesions in a Porcine Model

Cited by 106 publications

References 11 publications

A clinical study of thermal monitoring techniques of ultrasound-guided microwave ablation for hepatocellular carcinoma in high-risk locations

A clinical study of thermal monitoring techniques of ultrasound-guided microwave ablation for hepatocellular carcinoma in high-risk locations

Interactive registration of 2D histology and 3D CT data for assessment of radiofrequency ablation treatment

Mean Scatterer Spacing Estimation in Normal and Thermally Coagulated Ex Vivo Bovine Liver

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