For many cities, abandoned or underused spaces pose a major challenge, but temporary use is being manifested as a tool that can offer solutions. So-called “meanwhile spaces” provide opportunities for city officials to create the conditions for the cultural economy to be supported while simultaneously meeting urban regeneration goals and supporting city marketing purposes. In European cities, such as Berlin, Ghent, Nantes, and Bremen, there are examples where “temporary urbanism” is being incorporated into mainstream policy and is forming part of the city’s identity and tourism promotion. Temporary use is discussed in the context of current challenges facing European cities (austerity crisis, unemployment, refugee crisis, lack of affordable housing or office space). In this paper, the focus is on the creative sector. More recently, the COVID-19 pandemic has sparked discussion on how temporary use can cover a community’s needs. In this contextual framework, the scope was to explore the conditions under which temporary use becomes an effective policy tool and discuss management issues and difficulties that may arise. A description and analysis of the particularities of initiatives that were implemented in Athens compared to the ones in other European cities are presented. This paper is partly based on the works of the Athens URBACT Refill project, which included an extended consultation process with local stakeholders. Further field research was conducted regarding how temporary use initiatives with a cultural focus have been managed and the way the relations between owners, managers, and users were formed. Feedback from users and stakeholders’ representatives is presented. The key findings refer to the evaluation of the approaches used in temporary use initiatives with a cultural focus, the future perspectives, and the difficulty with drawing early conclusions on the effectiveness of these initiatives and the impact on the reputation of the city. Finally, the discussion is linked with promoting Athens as a city that allows experimentation by citizens’ groups and cultural initiatives in the context of temporary interventions.