Creative Music Therapy and Neurodevelopmental Outcomes in Pre-term Infants at 2 Years: A Randomized Controlled Pilot Trial

Haslbeck, Friederike; Bucher, Hans Ulrich; Bassler, Dirk; Hagmann, Cornelia; Natalucci, Giancarlo

doi:10.3389/fped.2021.660393

Cited by 22 publications

(25 citation statements)

References 62 publications

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“…In terms of long‐term development, we found no substantial CMT treatment effect on language, cognitive and motor outcomes measured with Bayley‐III in EPTs at 2 years, consistent with three other small studies investigating the long‐term effect of music interventions in preterm infants 10,11,21 . Interestingly, these results contrast their primary trials' outcomes showing significantly enhanced brain network development 8,9 and neural processing of speech sound changes 22 at term equivalent age associated with better long‐term language and cognitive outcomes in these trials.…”

Section: Discussionsupporting

confidence: 87%

“…18 However, 2 years later, participation rates in the follow-up assessments were high (87.1%) and moderate (58.1%) 5 years later. This high-attrition rate is consistent with our consecutive RCT 10 and the general attendance rates for follow-up examinations in other countries. 19 One explanation and thereby bias may be that parents of children who develop well often skip the follow-up examinations, 20 whereby in our sample, some other reasons for non-compliance were that families moved abroad and were no longer reachable.…”

Section: Neurodevelopmental Outcomes At the Corrected Age Of Five Yearssupporting

confidence: 90%

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Creative music therapy for long‐term neurodevelopment in extremely preterm infants: Results of a feasibility trial

Haslbeck,

Adams,

Schmidli

et al. 2023

Acta Paediatrica

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AimWe tested the feasibility of a future randomised clinical trial (RCT) in which Creative Music Therapy (CMT), a family‐integrating individualised approach in neonatal care, could improve neurodevelopment in extremely preterm infants (EPTs).MethodsIn this feasibility trial, 12 EPTs received CMT, while the remaining 19 received standard neonatal care. Socio‐demographic data and perinatal complications were compared between groups as risk factors. Bayley Scales of Infant and Toddler Development at 2‐year follow‐up (FU2) and KABC‐II‐Kaufman Assessment Battery for Children at 5‐year follow‐up (FU5) were analysed using the Mann–Whitney U‐tests.ResultsTwenty‐seven (87.1%) and 18 (58.1%) EPTs attended the FU2 and FU5 examination, respectively. The rate of neurodevelopmental risk factors at birth of the two groups was quite similar. While there was no difference in the FU2 outcomes between groups, there were higher values in the CMT group's Fluid‐Crystallised Index of the KABC‐II.ConclusionOur results indicate neither a beneficial nor a detrimental effect of CMT on neurodevelopment at 2 years but a trend of improved cognitive outcomes at 5 years more similar to cognitive scores of term‐born infants than of standard treatment EPTs. The findings favour an RCT but must be interpreted cautiously due to the reduced sample size and non‐randomised design.

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Section: Discussionsupporting

confidence: 87%

Section: Neurodevelopmental Outcomes At the Corrected Age Of Five Yearssupporting

confidence: 90%

Creative music therapy for long‐term neurodevelopment in extremely preterm infants: Results of a feasibility trial

Haslbeck,

Adams,

Schmidli

et al. 2023

Acta Paediatrica

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“…Our findings were in line with other recent studies that showed similarly beneficial short-term effects of neonatal music interventions at term age [15][16][17] without long-term benefits. 18,19 These results imply that early music interventions may not improve long-term outcomes in preterm-born children, proposing more sustained interventions to be implemented and investigated. However, it should be considered that the sensitivity of Bayley-III has been criticised.…”

Section: Discussionmentioning

confidence: 99%

“…Recorded music 15,16 and infant‐directed lullaby singing offered by a trained music therapist, 17 in turn, have been shown to support brain development by promoting functional network connectivity at term age. However, no effects of these music interventions on neurodevelopmental outcomes were found at 12 and 24 months of age 18,19 …”

Section: Introductionmentioning

confidence: 99%

No impact of parental singing during the neonatal period on cognition in preterm‐born children at 2–3 years

et al. 2023

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Aim: Studies examining the long-term effects of neonatal music interventions on the cognition of children born preterm are scarce. We investigated whether a parental singing intervention before term age improves cognitive and language skills in preterm-born children. Methods: In this longitudinal, two-country Singing Kangaroo, randomised controlled trial, 74 preterm infants were allocated to a singing intervention or control group. A certified music therapist supported parents of 48 infants in the intervention group to sing or hum during daily skin-to-skin care (Kangaroo care) from neonatal care until term age. Parents of 26 infants in the control group conducted standard Kangaroo care. At 2-3 years of corrected age, the cognitive and language skills were assessed with the Bayley Scales of Infant and Toddler Development, Third Edition.Results: There were no significant differences in cognitive and language skills between the intervention and control groups at the follow-up. No associations between the amount of singing and the cognitive and language scores were found. Conclusion:Parental singing intervention during the neonatal period, previously shown to have some beneficial short-term effects on auditory cortical response inThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…Interventions to attenuate stress and stabilize the infant during this crucial phase hold promise to either prevent or attenuate damage to the developing brain. Research investigating long-term effects of music therapy is only evolving [ 7 , 8 ] but vital sign responses to music therapy as a surrogate parameter of short term-stabilisation has been well-studied [ 9 , 10 , 11 ]. Currently, the optimal setting in which music therapy should be applied is under investigation [ 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Physical Contact on Preterm Infants’ Vital Sign Response to Live Music Therapy

Kobus

Diezel

Dewan

et al. 2022

IJERPH

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Evidence that music therapy stabilises vital parameters in preterm infants is growing, but the optimal setting for therapy is still under investigation. Our study aimed to quantify the effect of physical contact during live music therapy in preterm infants born < 32 weeks’ gestational age (GA) on post-therapy vital sign values. Live music therapy was delivered twice-weekly until discharge from hospital to 40 stable infants < 32 weeks’ GA. Baseline and post-therapy heart rate, respiratory rate, oxygen saturation and physical contact during each session were recorded. 159 sessions were performed with, and 444 sessions without, physical contact. Descriptive and multivariable regression analyses based on directed acyclic graphs were performed. The mean GA was 28.6 ± 2.6 weeks, and 26 (65%) infants were male. Mean absolute values for heart and respiratory rates lowered during music therapy regardless of physical contact. The mean post-therapy SaO2 was higher compared to baseline values regardless of physical contact (mean differences −8.6 beats/min; −13.3 breaths/min and +2.0%). There were no clinically relevant changes in vital sign responses between therapy sessions, with or without physical contact, or adjusted post-therapy values for any of the studied vital signs. Physical contact caused better baseline and post-therapy vital sign values but did not enhance the vital sign response to music therapy. Thus, the effect of music therapy on preterm infants’ vital signs is independent of physical contact and parents’ presence during music therapy in the neonatal intensive care unit.

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Creative Music Therapy and Neurodevelopmental Outcomes in Pre-term Infants at 2 Years: A Randomized Controlled Pilot Trial

Cited by 22 publications

References 62 publications

Creative music therapy for long‐term neurodevelopment in extremely preterm infants: Results of a feasibility trial

Creative music therapy for long‐term neurodevelopment in extremely preterm infants: Results of a feasibility trial

No impact of parental singing during the neonatal period on cognition in preterm‐born children at 2–3 years

Impact of Physical Contact on Preterm Infants’ Vital Sign Response to Live Music Therapy

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