Creative research in the chemical industry – Four decades in retrospect

Abstract

My professional research career spanning more than four decades has been largely devoted to synthetic medicinal chemistry (Ciba, Bombay-now Mumbai-21 years) followed by an equal number of years in process development of drugs, crop protection chemicals (Searle, Bombay) and drugs and speciality chemicals (Recon and Hikal, Bangalore). These efforts have involved several collaborators including many from other institutions and offered multitudinous challenges calling for continuous creativity in industrial setups. I was fortunate to have had a conducive environment to be able to respond to these challenges. I attempt to offer the readers in the ensuing pages a flavour of the excitement that has marked these years.

Development and Validation of UV Spectrophotometric Method for Simultaneous Estimation of Quinfamide and Mebendazole in in-house Pharmaceutical Formulation

“…QFN is chemically [1-(2, 2-dichloroacetyl)-3, 4-dihydro-2H-quinolin-6-yl] furan-2-carboxylate [5] ( Fig. 1) having antiparasitic properties consist of dichloroacetamide function [6,7].QFN is an antiamoebic agent used in the intestinal lumen, is absorbed at least possible levels, and is discard within 48 h, has been recognized to be an efficient clinical antiamoebic in 80 to 90% of cases linking a single day of treatment [8,9]. MEB chemically, Methyl-5-benzoyl-2-benzimidazole carbamate (Fig.…”

Synthesis of Diastereoenriched Oxazolo[5,4-b]indoles via Catalyst-Free Multicomponent Bicyclizations

“…Fused indoline heterocycles as key core components are prevalent in a large number of biologically significant alkaloids, natural products, and pharmaceuticals . As such, substantial effort has been paid to develop efficient and straightforward methods to synthesize those molecules for their diverse bioactivity profiles, which include anti-inflammatory, and analgesic, potent neuroleptic, and antitumor . Most of the synthetic endeavors to construct this bioactive core involve the cascade annulation of indoles .…”