CREB-binding Protein Is a Transcriptional Coactivator for Hepatocyte Nuclear Factor-4 and Enhances Apolipoprotein Gene Expression

Abstract

Hepatocyte nuclear factor-4 (HNF-4) is a liver-enriched transcription factor that is crucial in the regula

Regulation of Vascular Endothelial Growth Factor D by Orphan Receptors Hepatocyte Nuclear Factor-4α and Chicken Ovalbumin Upstream Promoter Transcription Factors 1 and 2

“…p160 proteins typically link other coactivators to the transcription initiation complex, whereas CBP/p300 can directly acetylate histones and/or other components of the transcription initiation complex (47). Similarly, orphan receptor HNF-4a was shown to interact with CBP/ p300 and GRIP-1 (48,49). In line with these studies, we found that CBP and GRIP-1 were associated with HNF-4a at the proximal vegf-D promoter (Fig.…”

Rescue of MODY-1 by Agonist Ligands of Hepatocyte Nuclear Factor-4α

“…In analogy with other nuclear receptors, transactivation of HNF-4␣ is mediated by protein coactivators (e.g. CBP (cAMP-response element-binding protein (CREB)-binding protein)/P300, PGC-1, and others) (27)(28)(29)(30).…”

Early foetal programming of hepatic gluconeogenesis: glucocorticoids strike back

“…The co-activator peroxisome proliferative activated receptor, gamma, coactivator 1 alpha (PPARGC1A) also activates Pck1 expression through specific interaction with HNF4A, without binding directly to the Pck1 promoter [25]. HNF4A has been associated with recruiting coactivator protein (CREB binding protein/ p300) and the ability to mediate chromatin remodelling [26][27][28]. Whether these other regulators are also involved in stimulating PCK gene transcription directly in response to early glucocorticoid exposure was not explored in the report by Nyirenda et al [17].…”