Credibility of the Neutrophil-to-Lymphocyte Count Ratio in Severe Traumatic Brain Injury

Siwicka-Gieroba, Dorota; Dąbrowski, Wojciech

doi:10.3390/life11121352

Cited by 4 publications

(2 citation statements)

References 133 publications

(142 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For total cholesterol, it has been reported that it predicts increased length of hospital stays in patients with trauma [ 32 ] and that hypocholesterolemia is associated with mortality in patients with head trauma [ 33 ]. Although there are few reports on lymphocyte counts in general patients with trauma, in recent years, several reports have suggested that the neutrophil/lymphocyte ratio is an indicator of prognosis in patients with head injury [ 34 ]. In brain injury following ischemic stroke, lymphocytes are said to contribute to the repair of the brain tissue [ 35 ], and there are also reports of decreased lymphocyte counts in patients with head trauma [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Patients with Severe Trauma Having an Injury Severity Score of 24 and above Develop Nutritional Disorders

Mizuochi,

Yamaguchi,

Chiba

et al. 2024

Diagnostics

View full text Add to dashboard Cite

In this single-center, retrospective, observational study, we aimed to assess the severity at which patients with trauma tend to develop metabolic disturbances that worsen their Controlling Nutritional Status (CONUT) scores. Participants were general adult patients with trauma hospitalized for at least one week. Injury Severity Scores (ISSs) at admission and CONUT scores one week later were calculated, and correlation coefficients were examined. The receiver operating characteristic (ROC) curve was used to calculate the ISS cutoff value for a CONUT score of 5 or more on day 7 of hospitalization. The ISS was assessed using multiple logistic regression analysis to determine whether it predicts worse nutritional status. Forty-nine patients were included. ISSs correlated with CONUT scores on day 7 (r = 0.373, p = 0.008). Using the ROC curve, the cutoff value for the ISS was 23.5. Multiple logistic regression analyses showed that a high ISS (odds ratio [OR], 1.158; 95% confidence interval [CI], 1.034–1.296; p = 0.011) and older age (OR, 1.094; 95% CI, 1.027–1.165; p = 0.005) were associated with a CONUT score 5 or more on day 7 of hospitalization. Patients with trauma with an ISS of 24 or higher have worsening CONUT scores during hospitalization; these patients require careful nutritional management.

show abstract

Section: Discussionmentioning

confidence: 99%

Patients with Severe Trauma Having an Injury Severity Score of 24 and above Develop Nutritional Disorders

Mizuochi,

Yamaguchi,

Chiba

et al. 2024

Diagnostics

View full text Add to dashboard Cite

show abstract

“…Interferon gamma is mainly involved in immune regulation, and its expression level is associated with neurological diseases ( Zhang et al, 2020 ; Döhne et al, 2022 ; Wen et al, 2022 ). TBI could induce a serial of cytokines, including interferon gamma and activate various types of immune cells ( Siwicka-Gieroba and Dabrowski, 2021 ; Salem et al, 2022 ). A published study on status epileptics suggests that intraventricular injection of recombinant interferon gamma may reduce neuron damage on rat hippocampus ( Ryu et al, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

Exploring the pathogenesis linking traumatic brain injury and epilepsy via bioinformatic analyses

Zhao

Fu²,

Yang³

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

Traumatic brain injury (TBI) is a serious disease that could increase the risk of epilepsy. The purpose of this article is to explore the common molecular mechanism in TBI and epilepsy with the aim of providing a theoretical basis for the prevention and treatment of post-traumatic epilepsy (PTE). Two datasets of TBI and epilepsy in the Gene Expression Omnibus (GEO) database were downloaded. Functional enrichment analysis, protein–protein interaction (PPI) network construction, and hub gene identification were performed based on the cross-talk genes of aforementioned two diseases. Another dataset was used to validate these hub genes. Moreover, the abundance of infiltrating immune cells was evaluated through Immune Cell Abundance Identifier (ImmuCellAI). The common microRNAs (miRNAs) between TBI and epilepsy were acquired via the Human microRNA Disease Database (HMDD). The overlapped genes in cross-talk genes and target genes predicted through the TargetScan were obtained to construct the common miRNAs–mRNAs network. A total of 106 cross-talk genes were screened out, including 37 upregulated and 69 downregulated genes. Through the enrichment analyses, we showed that the terms about cytokine and immunity were enriched many times, particularly interferon gamma signaling pathway. Four critical hub genes were screened out for co-expression analysis. The miRNA–mRNA network revealed that three miRNAs may affect the shared interferon-induced genes, which might have essential roles in PTE. Our study showed the potential role of interferon gamma signaling pathway in pathogenesis of PTE, which may provide a promising target for future therapeutic interventions.

show abstract

Neutrophil-albumin ratio serves as a superior prognostic biomarker for traumatic brain injury

Li,

Wang,

Liu

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Traumatic brain injury (TBI) represents a common and severe medical condition necessitating prompt risk stratification to enhance patient outcomes. Although substantial research has been conducted on the prognostic utility of various biomarkers for TBI, no single biomarker has been definitively recognized as the most precise predictor of disease outcomes. In comparison to other markers, the neutrophil-albumin ratio (NAR) has emerged as a cost-effective and reproducible inflammatory biomarker, demonstrating potential in evaluating the severity of inflammation and prognosticating outcomes in infections and cerebrovascular diseases. This study evaluated the prognostic significance of the NAR in comparison to two other readily accessible and cost-effective composite indices: the Neutrophil-Lymphocyte Ratio (NLR) and the Platelet-Lymphocyte Ratio (PLR) in individuals with TBI. We conducted a retrospective cohort analysis involving 297 hospitalized TBI patients, gathering comprehensive demographic, anthropometric, medical, clinical, laboratory, and imaging data to assess the expression changes of these biomarkers. Our findings suggest that both the NAR and the NLR possess predictive value regarding prognosis following TBI. However, receiver operating characteristic (ROC) curve analysis revealed that NAR outperformed NLR as a prognostic predictor. In conclusion, our examination of blood biochemistry composite indicators indicates that, while both NAR and NLR serve as significant prognostic markers, NAR is a more effective predictor of outcomes in patients with TBI.

show abstract

Credibility of the Neutrophil-to-Lymphocyte Count Ratio in Severe Traumatic Brain Injury

Cited by 4 publications

References 133 publications

Patients with Severe Trauma Having an Injury Severity Score of 24 and above Develop Nutritional Disorders

Patients with Severe Trauma Having an Injury Severity Score of 24 and above Develop Nutritional Disorders

Exploring the pathogenesis linking traumatic brain injury and epilepsy via bioinformatic analyses

Neutrophil-albumin ratio serves as a superior prognostic biomarker for traumatic brain injury

Contact Info

Product

Resources

About