Powder metallurgy (PM) Ni-based superalloys are widely used for aeroengine turbine disc applications due to their excellent mechanical properties and good corrosion resistance at elevated temperatures. Understanding the fatigue crack growth (FCG) mechanisms of PM Ni-based superalloys is important for both disc alloy development and life prediction of disc components in these advanced aeroengines where damage tolerance design prevails. FCG in PM Ni-based superalloys is a complicated function of microstructure, temperature, loading conditions and environment and is usually a consequence of the synergistic effects of fatigue, creep and environmental damage. In this review, the mechanisms controlled by microstructural features including grain size, grain misorientation, γ′ size and distribution on short and long FCG behaviour in PM Ni-based superalloys are discussed. The contribution of creep and environmental damage to FCG has been critically assessed. The competing effects of mechanical damage (i.e. fatigue and creep) and environmental damage at the crack tip are microstructure-sensitive, and usually results in transition between transgranular, mixed-trans-intergranular and intergranular FCG depending on the contribution of environmental damage to FCG processes.