Creep Feeding Supplemented with Roughages Improve Rumen Morphology in Pre-Weaning Goat Kids

Htoo, Nay Naing; Zeshan, Basit; Khaing, Aung Tun; Kyaw, Than S.; Woldegiorgis, Erkihun Aklilu; Khan, Mohd Azam Khan Goriman

doi:10.17582/journal.pjz/2018.50.2.703.709

Cited by 9 publications

(7 citation statements)

References 13 publications

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“…However, the difference in creep intakes reversed with the gradually weaned kids showing higher creep feed intakes during both gradual weaning periods and, while not significant, the PostWean intakes trended toward a higher mean value. As creep intake is critical to rumen development and successful weaning [Calves, Coverdale et al ( 51 )], and higher creep feed intake results in improved rumen morphology [goat kids, Htoo et al ( 52 )], this finding is of particular interest to farms weaning their kids at a young age when they may not have started ingesting significant amounts of solid feed. The gradually weaned kids also showed a significantly higher level of water intake post-weaning.…”

Section: Discussionmentioning

confidence: 99%

Gradually weaning goat kids may improve weight gains while reducing weaning stress and increasing creep feed intakes

et al. 2023

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Most dairy goat farms rear kids on ad libitum milk replacer; calf research suggests this improves growth and welfare, but solid feed intakes are problematic. Weaning can be gradual (incremental milk reduction) or abrupt (sudden, complete milk removal, which evidence suggests reduces welfare). Three treatments were created: abrupt weaning (AW: ad libitum milk until weaning) and gradual weaning [milk ad libitum until day 35, then milk unavailable 3.5 h/day until day 45 when milk removal was a 7 h/day block (gradual weaning 1: GW1) or two 3.5 h/day blocks (gradual weaning 2; GW2)]; complete milk removal occurred at day 56 for all. Experiment 1 investigated on-farm feasibility, behavior, and average daily gain (ADG). Experiment 2 investigated feed intakes, behavior, and ADG for AW and GW2. Experiment 1 had 261 kids (nine pens of 25–32), CCTV recorded 6 h/day, and group-level scan sampling recorded target behaviors. Kruskal–Wallis tests showed GW2 kids spent more time feeding on solids during weaning (p = 0.001) and displayed lower levels of ‘frustrated suckling motivation’ PostWean (p = 0.008). However, feeding competition differed PreWeaning (p = 0.007). ADG data from 159 female kids analyzed by a general linear model (fixed factor: treatment; covariate: day 34 weight) found GW2 had the highest ADG from day 35–45 (p ≤ 0.001) and no differences from day 45 to 56, and AW had the highest ADG PostWean (day 56–60). Experiment 2 had two AW pens (9 kids/pen) and two GW2 pens (8 and 9 kids/pen). A computerized feeder recorded milk intakes from day 22 to 56. Pen-level solid feed/water intakes were recorded from day 14–70. General linear models (fixed factor: treatment; covariate: PreWean value) found GW2 kids had higher ADG (p = 0.046) and lower milk intake (p = 0.032) from day 45–55, and PostWean (day 56–70) trended toward GW2 higher ADG (p = 0.074). Mann–Whitney U tests showed pen-level feed intake differences: AW had higher creep and straw throughout, GW2 showed higher creep during weaning (day 35–55), and higher water PostWean (>56 d). Behavioral observations suggest that gradually weaned kids may have enhanced welfare. Pen-level gradual weaning is feasible and, while weight gain results were mixed, it reduced milk intake, increased creep intake, and therefore combined with behavioral evidence can be recommended.

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Section: Discussionmentioning

confidence: 99%

Gradually weaning goat kids may improve weight gains while reducing weaning stress and increasing creep feed intakes

et al. 2023

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“…Among them, six miRNAs (miR-143, miR-29b, miR-145, miR-493, miR-26a and miR-199) were identified as the key regulators of rumen development in cattle [33]. From fetal to adulthood, the morphology, structure and function of the rumen change significantly, especially the surface area of the rumen papillae of goats under supplementary feeding significantly increased during the pre-and post-weaning periods [34]. Compared with the rumens at post-weaning period, a similar number of DEMs were detected in the pre-natal rumens (82 DEMs in the comparison of E60 and D150; 111 DEMs in the comparison of E135 and D150; Supplementary Figure S2).…”

Section: Discussionmentioning

confidence: 99%

Comparison of MicroRNA Transcriptomes Reveals the Association between MiR-148a-3p Expression and Rumen Development in Goats

Zhong

Wang

et al. 2020

Animals

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The rumen is an important digestive organ of ruminants. From the fetal to adult stage, the morphology, structure and function of the rumen change significantly. However, the knowledge of the intrinsic genetic regulation of these changes is still limited. We previously reported a genome-wide expression profile of miRNAs in pre-natal goat rumens. In this study, we combined and analyzed the transcriptomes of rumen miRNAs during pre-natal (E60 and E135) and post-natal (D30 and D150) stages. A total of 66 differentially expressed miRNAs (DEMs) were identified in the rumen tissues from D30 and D150 goats. Of these, 17 DEMs were consistently highly expressed in the rumens at the pre-weaning stages (E60, E135 and D30), while down-regulated at D150. Noteworthy, annotation analysis revealed that the target genes regulated by the DEMs were mainly enriched in MAPK signaling pathway, Jak-STAT signaling pathway and Ras signaling pathway. Interestingly, the expression of miR-148a-3p was significantly high in the embryonic stage and down-regulated at D150. The potential binding sites of miR-148a-3p in the 3′-UTR of QKI were predicted by the TargetScan and verified by the dual luciferase report assay. The co-localization of miR-148a-3p and QKI through in situ hybridization was observed in the rumen tissues but not in the intestinal tracts. Moreover, the expression of miR-148a-3p in the epithelium was significantly higher than that in the other layers of the rumen, suggesting that miR-148a-3p is involved in the development of the rumen epithelial cells by targeting QKI. Subsequently, miR-148a-3p inhibitor was found to induce the proliferation of GES-1 cells. Taken together, our study identified DEMs involved in the development of the rumen and provides insights into the regulation mechanism of rumen development in goats.

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“…It was notable that the rumen function was absorption maternal glucose in embryonic stage, while solely obtain energy from SCFA in feed after weaning. From fetal to birth and adult stage, the morphology, structure and function of rumen have signi cantly changed, especially the surface area of the rumen papillae of goats under supplementary feeding signi cantly increased during the pre-and post-weaning periods [30]. 66 DEMs were observed between the rumens at D30 and D150 (Fig.…”

Section: Discussionmentioning

confidence: 99%

Analysis of MicroRNA Transcriptomes Insights into the miR-148a-3p Inducer of Rumen Development in Goats

Zhong

Wang

et al. 2020

Preprint

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Abstract Background: Rumen is an important digestive organ of ruminant. From fetal to adult stage, the morphology, structure and function of rumen have changed significantly. But the intrinsic genetic regulation is still limited. We previously reported a genome-wide expression profile of miRNAs in prenatal goat rumens. In the present study, we rejoined analyzed the transcriptomes of rumen miRNAs during prenatal (E60 and E135) and postnatal (D30 and D150) stages.Results: A total of 66 differentially expressed miRNAs (DEMs) were identified in the rumen tissues from D30 and D150 goats. Of these, 17 DEMs were consistently highly expressed in the rumens at the preweaning stages (E60, E135 and D30), while down-regulated at D150. Noteworthy, annotation analysis revealed that the target genes regulated by the DEMs were mainly enriched in MAPK signaling pathway, Jak-STAT signaling pathway and Ras signaling pathway. Interestingly, the expression of miR-148a-3p was significantly high in the embryonic stage and down-regulated at D150. The potential binding sites between miR-148a-3p and QKI were predicted by the TargetScan and verified by the dual luciferase report assay. The co-localization of miR-148a-3p and QKI was observed not in intestinal tracts but in rumen tissues by in situ hybridization. Moreover, the expression of miR-148a-3p in the epithelium was significantly higher than that in the other layers, suggesting that miR-148a-3p involve in the development of rumen epithelial cells by targeting QKI. Subsequently, miR-148a-3p inhibitor was found to induce the proliferation of GES-1 cells.Conclusions: Taken together, these results identified the DEMs involved in the development of rumen and provided an insight into the regulation mechanism of goat rumens during development.

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Creep Feeding Supplemented with Roughages Improve Rumen Morphology in Pre-Weaning Goat Kids

Cited by 9 publications

References 13 publications

Gradually weaning goat kids may improve weight gains while reducing weaning stress and increasing creep feed intakes

Gradually weaning goat kids may improve weight gains while reducing weaning stress and increasing creep feed intakes

Comparison of MicroRNA Transcriptomes Reveals the Association between MiR-148a-3p Expression and Rumen Development in Goats

Analysis of MicroRNA Transcriptomes Insights into the miR-148a-3p Inducer of Rumen Development in Goats

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