Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans

Busso, Cleverson; Castro-Prado, Marialba Avezum Alves de

doi:10.1590/s0001-37652004000100005

Cited by 3 publications

(4 citation statements)

References 26 publications

(19 reference statements)

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“…Sap value was found practically constant post 1wt% catalyst concentration. The authors have supported their data with the plot of figures as presented by Figures 6-11 [35,36].…”

Section: Transesterification Of Castor Oilsupporting

confidence: 56%

“…Acid value had shown similar trend as that of viscosity. Sap value too shown similar trend as that of specific gravity (Table 7) [35][36][37]. According to their observation the specific gravity of the product was lowest at 1wt % catalyst concentration and increased with increasing catalyst concentration up to 2wt%.…”

Section: Transesterification Of Castor Oilmentioning

confidence: 57%

“…The variation of specific gravity with residence time in their study appeared in a similar trend as that of viscosity. Decrease in the Specific gravity was observed from 0.9096 to 0.882 as residence time is increased from 30 to 45 minutes, further increase in residence time from 60 to 90 minutes the specific gravity increased 0.882 to 0.9026 while acid value of biodiesel product decreased with increasing reaction time and saponification value decreased with increasing reaction time and further increases [34][35][36]. Table 6 presents their data of variation in viscosity with time.…”

Section: Transesterification Of Castor Oilmentioning

confidence: 99%

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Castor Oil and Its Derivatives’ With Market Growth, Commercial Perspective: Review

Nautiyal¹

2018

OMCIJ

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Within the chemical industry oleo-chemicals from Castor beans carry a strong and potential pattern. With some of the old important processes and products are replaced by the new in its constant changes. Some products over the years in contrast that were decline have been revived in accordance with the introduction of new technology and applications. New market demands have mounted heavy pressure on castor chemistry and have responded with great vigor. BSS castor oil is used in wide variety of applications and is the starting material for many other derivatives of castor oil. In pharmaceuticals and cosmetics it is used as an ingredient in formulations. It combines well with styrene and diisocyanates for film forming as well varnish. It is substantially insoluble infusible polymer and is used as lubricant component of coatings for vitamin and mineral tablets. It is also important ingredient for petroleum oil and de emulsification. Ricinoleic acid is also known as castor oil acid and belongs to a family of the unsaturated fatty acid. The Principal Castor Reactions are as follows;

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“…Sap value was found practically constant post 1wt% catalyst concentration. The authors have supported their data with the plot of figures as presented by Figures 6-11 [35,36].…”

Section: Transesterification Of Castor Oilsupporting

confidence: 56%

Section: Transesterification Of Castor Oilmentioning

confidence: 57%

Section: Transesterification Of Castor Oilmentioning

confidence: 99%

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Castor Oil and Its Derivatives’ With Market Growth, Commercial Perspective: Review

Nautiyal¹

2018

OMCIJ

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“…1). The homozygotization index (HI), or the ratio between prototrophic and auxotrophic segregants, equal to or over 2.0 (4+/2-), reveals the recombinagenic effect of the compound under analysis (Pires & Zucchi 1994, Chiuchetta & Castro-Prado 2002, Busso & Castro-Prado 2004. …”

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confidence: 99%

Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans

Kaneshima

Castro-Prado

2005

Mem. Inst. Oswaldo Cruz

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Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were not observed, 75 and 100 µM benznidazole induced an increasing of mitotic recombination events in diploid strain. Results were related to the induction of chromosomal breaks by the antiparasitic drug.Key words: benznidazole -somatic recombination -genotoxicity -homozigotization index Chagas disease, caused by Trypanosoma cruzi, is one of the most serious parasitic diseases of Latin America, where some 16 -18 million people are infected by the T. cruzi (WHO 1991). Although in Brazil the disease is under strict control, there are still about 4 million people infected by the parasite (Dias 1998). Benznidazole is used in the treatment of Chagas disease in the acute phase, at the start of the chronic phase, in congenital cases and accidental infection (Fragata Filho et al. 1997). Several adverse effects have been described in patients undergoing treatment with the anti-parasitic drug (Cançado 1997, Fragata Filho et al. 1997.The mutagenic action of the benznidazol has been studied in streptomycin-resistant Klebsiella pneumoniae strain and in Salmonella typhimurium TA100 strain. Mutagenic effect of the drug has also been observed in TA100 strain in the presence and in the absence of the microsomal hepatic fraction of mice, using 50 to 1000 µM concentrations (Voogd et al. 1975, Nagel & Nepomnaschy 1983.The mutagenic activity of benznidazole has also been determined in the simplified version of Ames test with sensitive (TA100 and TA102) and less sensitive (TA98 and TA97) S. typhimurium strains (Melo & Ferreira 1990) in the same plate. The drug's mutagenic effect was accounted to the interaction of reactive metabolites of benznidazole with the DNA and with nuclear proteins (Gorla et al. 1986, Zahoor et al. 1987, Ferreira et al. 1988).Benznidazole's genotoxicity has been studied in peritoneal macrophages of mice treated with benznidazole (Lacava & Luna 1994). These authors reported the clastogenic effect of the drug owing to increase in the frequency of chromatid breaks and to the formation of acrocentric chromosomes. Moya and Trombotto (1988) In spite of these contradictory results, the clastogenic effect of benznidazole (Lacava & Luna 1994) suggest its participation in the carcinogenic process due to the occurrence of mitotic crossing-over that induces the loss of heterozygosity of tumor suppressor genes (Zimmermann 1971, Weinberg 1991, Beumer et al. 1998. The evaluation of the recombinagenic potential of benznidazol in heterozygous cells of Aspergillus nidulans will be provided. Information on the participation of the anti-parasitic drug in the carcinogenesis process will be thus ensued. MATERIALS AND METHODSStrains and culture media -A. nidulans strains used are described in Table I. Minimum medium (MM) was Czape-Dox with 1% (w/v) glucose. Complete medium (CM) has pre...

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