Conventional complete dentures have long been considered as one of the treatment options for restoring the esthetics and function of edentulous patients. It has the advantages of being the cheapest treatment for replacing the entire teeth in the upper and lower jaws, the shortest treatment time from start to finish, and an esthetically acceptable treatment regime. However, it has inherent disadvantages, such as low retention, lack of stability, and low chewing efficiency, especially in patients with alveolar ridge atrophy [1,2]. Implant-supported fixed dentures are still considered the best treatment option for the rehabilitation of edentulous patients; however, many patients cannot afford the high price of such treatment. Therefore, to overcome the lack of retention and stability of conventional dentures, particularly in the mandible, and the high cost of implant-supported fixed prostheses, implant-supported overdentures (ODs) have long been considered alternative treatment options. It is a removable prosthesis supported by single, two, or more dental implants via attachment systems (e.g., ball, bar, locator, magnet, or resilient telescopic). This treatment has been reported to be superior to conventional dentures in terms of patient satisfaction, function (ability to speak and chew, comfort, social contact), and quality of life [3][4][5].To date, a heated debate still exists regarding the effect of different OD attachment systems (OAS) and different numbers of dental implants on peri-implant health [6][7][8][9]. Although mandibular two implant-supported ODs are considered the first choice standard of care for edentulous patients, according to the York Consensus Statement[10] evidence regarding the number of dental implants and attachment systems for supporting mandibular ODs has the least marginal bone loss (MBL), pocket probing depth (PPD), bleeding index (BI), plaque index (PI), gingival index (GI) and higher implant survival rate (ISR) is lacking.